Botanical species · safety record

Physostigma venenosum

The EFSA Compendium of Botanicals holds 4 constituent measurements and 4 adverse-effect records for Physostigma venenosum. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Physostigma venenosum Balf.

4Constituent measurements

4Safety records

3Cited sources

24Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 24 licensed products naming Physostigma venenosum as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Source material stated

Fève
Grain(s)
Seed
Seed(s)

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Eseramine	Seed	Solvent extraction	—	—	Resolve DOI
Physostigmine	Seed	Solvent extraction	—	—	Resolve DOI
Physovenine	Seed	Solvent extraction	—	—	Resolve DOI
Colchicin	Seed	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Not reported	—	Seed	—	—	Case report	Resolve DOI
Reproductive	Uterus	Seed	—	Human (as organism)	Case report	Resolve DOI
Systemic	Digestive	Seed	—	Human (as organism)	Case report	Resolve DOI
Systemic	Digestive	Seed	—	Human (as organism)	Case report	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Ikpa, C. B. C., Johnbull, E. O. Isolation and characterization of Colchicine from Physostigma venenosum. Iosr journal of applied chemistry, 2013, vol. 5, no. 6), 51-5, p. 4 pp.
Proudfoot, Alex. The early toxicology of physostigmine: a tale of beans, great men and egos. . Toxicological reviews, 2006, vol. 25, no. 2, p. 99-138. DOI
Salway, A.H. CCXLII. - Chemical examination of Calabar beans. Journal of the chemical society, transactions, 1911, vol. 99, p. 2148-2159. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature