Botanical species · safety record

Picrorhiza lindleyana

The EFSA Compendium of Botanicals holds 11 constituent measurements and 1 adverse-effect record for Picrorhiza lindleyana. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Picrorhiza lindleyana (Wall.) Steud.

11Constituent measurements

1Safety records

7Cited sources

0Licensed products (Canada)

Also recorded as

Picrorhiza kurrooa Benth.

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Cucurbitacins	Aerial part of plants	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Picrotoxin	Live plants	Solvent extraction	≥ 0.15 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Picrotoxin	Live plants	Solvent extraction	≤ 2.2 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Picrotoxinin	Roots and other underground parts	Solvent extraction	≥ 24 Microgram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Picrotoxinin	Roots and other underground parts	Solvent extraction	≤ 29.2 Microgram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Picrotoxinin	Roots and other underground parts	Solvent extraction	≥ 43.5 Microgram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Picrotoxinin	Roots and other underground parts	Solvent extraction	≤ 51.9 Microgram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Picrotoxinin	Roots and other underground parts	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Picrotoxin	Roots and other underground parts	Solvent extraction	≤ 2.2 Percent	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	No resolvable identifier
Picrotoxin	Roots and other underground parts	Solvent extraction	≥ 1.1 Percent	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	No resolvable identifier
Saponins	Roots and other underground parts	Solvent extraction	—	Phytochemical screening	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
None	Skin/subcutis	Unspecified	Solvent extraction	House mouse (as animal)	Other	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Talmale, V.R., More, P.R., Ghumare, B.C., Shendre, S.B., Nirgulkar, S.N. Efficacy of Pcroriza kurrooa benth in experimentally induced hepato-toxicity in cross-bred calves. Veterinary world, 2010, vol. 3, no. 1, p. 29-31.
Bohra, Neetu., Prasad, P., Tewari, Geeta., Tewari, Lalit M. Variation in picrotin and picrotoxin content of Picrorhiza kurroa royle ex benth rhizomes from garhwal himalaya. Journal of the indian chemical society, 2015, p. 375-378.
Rawat, Janhvi Mishra., Rawat, Balwant., Mehrotra, Shakti. Plant regeneration, genetic fidelity, and active ingredient content of encapsulated hairy roots of Picrorhiza kurrooa Royle ex Benth. . Biotechnology letters, 2013, vol. 35, no. 6, p. 961-968. DOI
Mishra, J., Bhandari, H., Singh, M., Rawat, S., Agnihotri, R.K., Mishra, S., Purohit, S. Hairy root culture of Picrorhiza kurroa Royle ex Benth.: A promising approach for the production of picrotin and picrotoxinin. Acta physiologiae plantarum, 2011, vol. 33, no. 5, p. 1841-1846. DOI
Lee, Hyeung Sik., Ku, Sae Kwang. Effects of Picrorrhiza Rhizoma on acute inflammation in mice. Biomolecules therapeutics, 2008, p. 137-140.
Sturm, S., Stuppner, H. Analysis of cucurbitacins in medicinal plants by high-pressure liquid chromatography-mass spectrometry. Phytochemical analysis, 2000, vol. 11, no. 2, p. 121-127. DOI
Purohit, H., Nautiyal, B.P., Nautiyal, M.C. Interpopulation variation in Picrorhiza kurrooa Royle ex Benth-step towards identifying genetic variability and elite strains for crop improvement study. American journal of plant physiology, 2008, vol. 3, no. 4, p. 154-164. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature