Botanical species · safety record

Pieris japonica

The EFSA Compendium of Botanicals holds 6 constituent measurements and 5 adverse-effect records for Pieris japonica. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Pieris japonica (Thunb.) D. Don ex G. Don

6Constituent measurements

5Safety records

11Cited sources

0Licensed products (Canada)

Also recorded as

Andromeda japonica Thunb.

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Grayanotoxins	Leaves	—	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Grayanotoxins	Flower	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Grayanotoxins	Flower	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Grayanotoxin i	Unspecified	—	—	Unspecified	No resolvable identifier
Grayanotoxin iii	Leaves	—	—	Unspecified	No resolvable identifier
Grayanotoxins	Flower	—	—	Chromatographic tests	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Digestive	Digestive	Leaves	—	Animals (as animal)	Case report	No resolvable identifier
Systemic	Cardiovascular / haematological	Aerial part of plants	—	—	Case report	No resolvable identifier
Systemic	Digestive	Leaves	Fresh	Goat (as animal)	Case report	No resolvable identifier
Systemic	Neurologic: central nervous system	Live plants	Solvent extraction	Human (as organism)	Case report	No resolvable identifier
Systemic	Digestive	Leaves	Fresh	Cattle (as animal)	Case report	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Plugge, P. C., de Zaayer, H. G. Andromedotoxin. Arch. ges. physiol., 40, 1889, vol. ges. Physiol., p. 40.
Meguri, Haruo. Constituents of ericaceae. V. Isolation of deacetylandromedotoxin (grayanotoxin III) and pieristoxin C from the leaves of Pieris japonica. Yakugaku zasshi, 1959, vol. 79, p. 1057-9.
van Roosmalen, S., van Oers, J.A.H. First Pieris Japonica intoxication described in a human. Netherlands journal of critical care, 2013, vol. 17, no. 5, p. 36-37.
Baert, K., Croubels, S., Steurbaut, N., De Boever, S., Vercauteren, G., Ducatelle, R., Verbeken, A., De Backer, P. Two unusual cases of plant intoxication in small ruminants. Vlaams diergeneeskundig tijdschrift, 2005, vol. 74, no. 2, p. 149-153.
HOTTA, Y., TAKEYA, K., KOBAYASHI, S., HARADA, N., SAKAKIBARA, J., SHIRAI, N. RELATIONSHIP BETWEEN STRUCTURE, POSITIVE INOTROPIC POTENCY AND LETHAL DOSE OF GRAYANOTOXINS IN GUINEA-PIG . Archives of toxicology, 1980, vol. 44, no. 4, p. 259-267. DOI
Meguri, Haruo. Constituents of ericaceae. IV Isolation of pieristoxin A, B, and C from the flowers of Pieris japonica. Yakugaku zasshi, 1959, vol. 79, p. 1052-6.
Aleguas, A., Vitale, C., Sheroff, A., Burns-Ewald, M. Grayanotoxin poisoning from Pieris japonica. Clinical toxicology, 2008, vol. 46, no. 5, p. 410-410.
Li, Yan-Ping., Li, Xiao-Nian., Gao, Ling-Huan., Li, Hai-Zhou., Wu, Guo-Xing., Li, Rong-Tao. Neopierisoids A and B, Two New Chlorinated 3,4-seco-Grayanane Diterpenoids with Antifeedant Activity from Flowers of Pieris japonica . Journal of agricultural and food chemistry, 2013, vol. 61, no. 30, p. 7219-7224. DOI
Toxoplasmosis causes abortion and non-viable lambs in a Scottish hill flock. Veterinary record, 2007, vol. 161, no. 4, p. 115-118.
Pizza, R., Goodman, G., Gunn-Moore, D., Meredith, A., Keeble, E. Pieris japonica intoxication in an African spurred tortoise (Geochelone sulcata) . Veterinary record, 2005, vol. 156, no. 15, p. 487-488.
Chen, Xuan-Qin., Gao, Ling-Huan., Li, Yan-Ping., Li, Hong-Mei., Liu, Dan., Liao, Xia-Li., Li, Rong-Tao. Highly Oxygenated Grayanane Diterpenoids from Flowers of Pieris japonica and Structure-Activity Relationships of Antifeedant Activity against Pieris brassicae . Journal of agricultural and food chemistry, 2017, vol. 65, no. 22, p. 4456-4463. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

Continue

Independent literature