Botanical species · safety record

Pilocarpus microphyllus

The EFSA Compendium of Botanicals holds 14 constituent measurements for Pilocarpus microphyllus. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Pilocarpus microphyllus Stapf ex Wardlew.

14Constituent measurements

0Safety records

6Cited sources

1Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 1 licensed products naming Pilocarpus microphyllus as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Source material stated

Leaf

What the records describe

Constituents measured

Plant parts

Preparations

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Alkaloids	Leaves	Solvent extraction	≥ 0.88 Percent	HPLC with standard detection methods	Resolve DOI
Alkaloids	Leaves	Solvent extraction	≤ 1.08 Percent	HPLC with standard detection methods	Resolve DOI
Epiisopiloturine	Leaves	Solvent extraction	≥ 0.019 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Epiisopiloturine	Leaves	Solvent extraction	≤ 0.383 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Imidazole alkaloids	Leaves	Solvent extraction	—	HPLC with standard detection methods	Resolve DOI
Imidazole alkaloids	Leaves	Solvent extraction	—	HPLC with standard detection methods	Resolve DOI
Pilocarpine	Leaves	Solvent extraction	≥ 23.6 Percent	HPLC with standard detection methods	Resolve DOI
Pilocarpine	Leaves	Solvent extraction	< 0.03 Percent	HPLC with standard detection methods	Resolve DOI
Pilocarpine	Leaves	Solvent extraction	≤ 34.5 Percent	HPLC with standard detection methods	Resolve DOI
Pilocarpine	Leaves	Solvent extraction	≥ 0.219 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Pilocarpine	Leaves	Solvent extraction	≤ 0.947 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Imidazole alkaloids	Leaves	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Pilocarpine	Leaves	Solvent extraction	≤ 235.9 Microgram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Pilocarpine	Leaves	Solvent extraction	≥ 16.3 Microgram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Sawaya, Alexandra C. H. F., Abreu, Ilka Nacif., Andreazza, Nathalia Luiza., Eberlin, Marcos N., Mazzafera, Paulo. HPLC-ESI-MS/MS of imidazole alkaloids in Pilocarpus microphyllus. Molecules, 2008, vol. 13, no. 7, p. 1518-1529. DOI
Helena Frankland Sawaya, Alexandra Christine., Vaz, Boniek Gontijo., Eberlin, Marcos Nogueira., Mazzafera, Paulo. Screening species of Pilocarpus (Rutaceae) as sources of pilocarpine and other imidazole alkaloids . Genetic resources and crop evolution, 2011, vol. 58, no. 3, p. 471-480. DOI
Abreu, Ilka N., Mazzafera, Paulo., Eberlin, Marcos N., Zullo, Marco Antonio T., Sawaya, Alexandra C. H. F. Characterization of the variation in the imidazole alkaloid profile of Pilocarpus microphyllus in different seasons and parts of the plant by electrospray ionization mass spectrometry fingerprinting and identification of novel alkaloids by tandem mass spectrometry . Rapid communications in mass spectrometry, 2007, vol. 21, no. 7, p. 1205-1213. DOI
Lima, David Fernandes., De Lima, Luiza Ianny., Rocha, Jefferson Almeida., De Andrade, Ivanilza Moreira., Grazina, Liliana Goncalves., Villa, Caterina., Meira, Liliana., Veras, Leiz Maria Costa., Azevedo, Iabita Fabiana Sousa., Biase, Adriele Giaretta., Costa, Joana., Oliveira, Maria Beatriz PP., Mafra, Isabel., Roberto De Souza De Almeida Leite, Jose. Pilocarpine (%, w/w) contents in S01, S02, and S03 over one year, measured with HPLC. . Figshare, 2017 . DOI: http://dx.doi.org/10.1371/journal.pone.0170281.t002. DOI
Vieira, Marianne M., Campelo, Yuri D M., Sakai, Vanessa Y., Lima, David F., Carvalho, Paulo S, Jr., Ellena, Javier A., Silva, Paulo R P., Vasconcelos, Luciene C., Godejohann, Markus., Petrilli, Helena M., Constantino, Vera R L., Mascarenhas, Yvonne P., Leite, Jose Roberto De Souza De Almeida., Veras, Leiz M C., Cunha, Vanessa R R., Lima, Filipe C D A., Guimaraes, Maria A. Industrial Scale Isolation, Structural and Spectroscopic Characterization of Epiisopiloturine from Pilocarpus microphyllus Stapf Leaves: A Promising Alkaloid against Schistosomiasis . Figshare, 2013.
Sandhu, Sardul Singh., Abreu, Ilka Nacif., Colombo, Carlos Augusto., Mazzafera, Paulo. Pilocarpine content and molecular diversity in Jaborandi. Scientia agricola, 2006, vol. 63, no. 5, p. 478-482.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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