Botanical species · safety record

Pimenta dioica

The EFSA Compendium of Botanicals holds 27 constituent measurements and 1 adverse-effect record for Pimenta dioica. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Pimenta dioica (L.) Merr.

27Constituent measurements

1Safety records

10Cited sources

18Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 18 licensed products naming Pimenta dioica as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Source material stated

Berries
Berry/Berries
Dried fruit
Fruit
Fruit oleoresin

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
1,8-cineole	Aerial part of plants	Essential oil	4.1 Percent	GC-MS	Resolve DOI
1,8-cineole	Fruit unspecified	Essential oil	≥ 1.9 Percent	GC-MS	Resolve DOI
1,8-cineole	Fruit unspecified	Essential oil	1.3 Percent	GC-MS	Resolve DOI
1,8-cineole	Fruit unspecified	Essential oil	≤ 4.1 Percent	GC-MS	Resolve DOI
4-hydroxy-3-methoxycinnamaldehyde	Fruit unspecified	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Eugenol	Fruit unspecified	Essential oil	14.9 Percent	GC-MS	Resolve DOI
Eugenol	Aerial part of plants	Essential oil	8.3 Percent	GC-MS	Resolve DOI
Gallic acid	Fruit unspecified	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Isoeugenol	Aerial part of plants	Essential oil	62.7 Percent	GC-MS	Resolve DOI
Methyleugenol	Fruit unspecified	Essential oil	≥ 48.3 Percent	GC-MS	Resolve DOI
Methyleugenol	Fruit unspecified	Essential oil	≤ 62.7 Percent	GC-MS	Resolve DOI
Methyleugenol	Fruit unspecified	Essential oil	67.9 Percent	GC-MS	Resolve DOI
Myrcene	Fruit unspecified	Essential oil	≥ 16.5 Percent	GC-MS	Resolve DOI
Myrcene	Fruit unspecified	Essential oil	6 Percent	GC-MS	Resolve DOI
Myrcene	Fruit unspecified	Essential oil	≤ 17.7 Percent	GC-MS	Resolve DOI
Phenylpropanoids	Fruit unspecified	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Phenylpropanoids	Fruit unspecified	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Phenylpropanoids	Fruit unspecified	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Phenylpropanoids	Fruit unspecified	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Piperidine	Fruit unspecified	Solvent extraction	0.66 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Piperine	Fruit unspecified	Solvent extraction	2.17 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Eugenol	Leaves	Essential oil	60.8 Percent	GC-MS	No resolvable identifier
Eugenol	Fruit unspecified	Solvent extraction	2.3 Percent	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	No resolvable identifier
Eugenol	Leaves	Solvent extraction	0.9 Percent	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	No resolvable identifier
Eugenol	Aerial part of plants	Essential oil	83.68 Percent	GC-FID	No resolvable identifier
Eugenol	Aerial part of plants	Essential oil	79.81 Percent	GC-FID	No resolvable identifier
Myrcene	Leaves	Essential oil	19.3 Percent	GC-MS	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Other toxicities	—	Leaves	Solvent extraction	House mouse (as animal)	Acute toxicity	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Martinez-Velazquez, Moises., Adolfo Castillo-Herrera, Gustavo., Rosario-Cruz, Rodrigo., Miguel Flores-Fernandez, Jose., Lopez-Ramirez, Julisa., Hernandez-Gutierrez, Rodolfo., del Carmen Lugo-Cervantes, Eugenia. Acaricidal effect and chemical composition of essential oils extracted from Cuminum cyminum, Pimenta dioica and Ocimum basilicum against the cattle tick Rhipicephalus (Boophilus) microplus (Acari: Ixodidae) . Parasitology research, 2011, vol. 108, no. 2, p. 481-487. DOI
Faria, Leonardo Rodrigues., Machado, Rubia Darc., Pimenta, Pedro Henrique., Oliveira, Leandra de Almeida Ribeiro., Peixoto, Josana de Castro., Realino de Paula, Jose., Ferri, Pedro Henrique., Marciano de Paula, Joelma Abadia. Structural organization and phytochemical analysis of Pimenta dioica (L.) Merrill (Myrtaceae) leaves collected from Goi�as State, Brazil. Journal of medicinal plants research, 2014, vol. 8, no. 38, p. 1134-1147.
Dighe, Vidya V., Charegaonkar, Gauri A. HPTLC quantitation of eugenol from leaf and berry powder of Pimenta dioica(L.) merr. Analytical chemistry: an indian journal, 2009, vol. 8, no. 1, p. 29-33.
Garc�a-Fajardo, J., Mart�nez-Sosa, M., Estarr�n-Espinosa, M., Vilarem, G., Gaset, A., de Santos, J.M. Comparative Study of the Oil and Supercritical CO2 Extract of Mexican Pimento (Pimenta dioica Merrill). Journal of essential oil research, 1997, vol. 9, no. 2, p. 181-185. DOI
Kikuzaki, H., Hara, S., Kawai, Y., Nakatani, N. Antioxidative phenylpropanoids from berries of Pimenta dioica. Phytochemistry, 1999, vol. 52, no. 7, p. 1307-1312. DOI
Logarto Parra, A., Silva Yhebra, R., Guerra Sardinas, I., Iglesias Buela, L. Comparative study of the assay of Artemia salina L. and the estimate of the medium lethal dose (LD50 value) in mice, to determine oral acute toxicity of plant extracts. . Phytomedicine : international journal of phytotherapy and phytopharmacology, 2001, vol. 8, no. 5, p. 395-400.
Kikuzaki, H., Sato, A., Mayahara, Y., Nakatani, N. Galloylglucosides from berries of Pimenta dioica. Journal of natural products, 2000, vol. 63, no. 6, p. 749-752. DOI
Minott, Donna A., Brown, Heather A. Differentiation of fruiting and non-fruiting Pimenta dioica (L.) Merr. trees based on composition of leaf volatiles . Journal of essential oil research, 2007, vol. 19, no. 4, p. 354-357.
Shamaladevi, Nagarajarao., Lyn, Dominic A., Shaaban, Khaled A., Zhang, Lei., Villate, Susana., Rohr, Juergen., Lokeshwar, Bal L. Ericifolin: a novel antitumor compound from allspice that silences androgen receptor in prostate cancer . Carcinogenesis, 2013, vol. 34, no. 8, p. 1822-1832. DOI
De Mey, Eveline., De Maere, Hannelore., Dewulf, Lore., Paelinck, Hubert., Sajewicz, Mieczyslaw., Fraeye, Ilse., Kowalska, Teresa. Assessment of the N-nitrosopiperidine formation risk from piperine and piperidine contained in spices used as meat product additives . European food research and technology, 2014, vol. 238, no. 3, p. 477-484. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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