Botanical species · safety record

Pinus pinaster

The EFSA Compendium of Botanicals holds 4 constituent measurements, 1 adverse-effect record and 2 genotoxicity assays for Pinus pinaster. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Pinus pinaster Aiton

4Constituent measurements

3Safety records

5Cited sources

311Licensed products (Canada)

Also recorded as

Pinus maritima Lam.

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 311 licensed products naming Pinus pinaster as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Dry
Fresh

Source material stated

Aged bark
Bark
Bark (trunk)
Bark and buds
Bark extract
Branch bark
French Maritime pine bark
Fruit

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Gallotannins	Bark	Solvent extraction	—	MALDI-TOFMS	Resolve DOI
Myrcene	Leaves	Essential oil	7.26 Percent	Gaschromatography (GC)	Resolve DOI
P-coumaric acid	Bark	Solvent extraction	≤ 2 Percent	Unspecified	Resolve DOI
P-coumaric acid	Bark	Solvent extraction	≥ 0.3 Percent	Unspecified	Resolve DOI

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Digestive	Digestive	Bark	—	—	In vitro	Resolve DOI

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	DNA damage and/or repair	in vitro mammalian cell micronucleus test	Human (as organism)	—	Resolve DOI
Positive	DNA damage and/or repair	single cell gel/comet assay in mammalian cells for detection of DNA damage	Human (as organism)	—	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Taner, Gokce., Aydin, Sevtap., Aytac, Zeki., Basaran, Arif Ahmet., Basaran, Nursen. Assessment of the cytotoxic, genotoxic, and antigenotoxic potential of Pycnogenol (R) in in vitro mammalian cells . Food and chemical toxicology, 2013, vol. 61, p. 203-208. DOI
Segal, L., Penman, M G., Piriou, Y. Evaluation of the systemic toxicity and mutagenicity of OLIGOPIN(R), procyanidolic oligomers (OPC) extracted from French Maritime Pine Bark extract. . Toxicology reports, 2018, vol. 5, p. 531-541. DOI
Barata, EN., Pickett, JA., Wadhams, LJ., Woodcock, CM., Mustaparta, H. Identification of host and nonhost semiochemicals of eucalyptus woodborer Phoracantha semipunctata by gas chromatography-electroantennography . Journal of chemical ecology, 2000, vol. 26, no. 8, p. 1877-1895. DOI
Navarrete, P., Pizzi, A., Pasch, H., Rode, K., Delmotte, L. MALDI-TOF and C-13 NMR characterization of maritime pine industrial tannin extract . Industrial crops and products, 2010, vol. 32, no. 2, p. 105-110. DOI
Schaefer, Angelika., Hoegger, Petra. Oligomeric procyanidins of French maritime pine bark extract (Pycnogenol (R)) effectively inhibit alpha-glucosidase . Diabetes research and clinical practice, 2007, vol. 77, no. 1, p. 41-46. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature