Botanical species · safety record

Piper cubeba

The EFSA Compendium of Botanicals holds 7 constituent measurements and 4 genotoxicity assays for Piper cubeba. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Piper cubeba L.f.

7Constituent measurements

4Safety records

5Cited sources

20Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 20 licensed products naming Piper cubeba as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Source material stated

Berries
Berry/Berries
Fruit
Fruit extract
Seed
Seed(s)

What the records describe

Constituents measured

Plant parts

Preparations

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
(-)-camphor	Fruit unspecified	Essential oil	5.61 Percent	GC-MS	Resolve DOI
1,8-cineole	Fruit unspecified	Essential oil	11.87 Percent	GC-MS	Resolve DOI
Hinokinin	Fruit unspecified	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Kadsurin	Unspecified	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Lignans	Fruit unspecified	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Lignans	Seed	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Neolignans	Unspecified	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	DNA damage and/or repair	single cell gel/comet assay in mammalian cells for detection of DNA damage	Rat (as animal)	Not applicable	No resolvable identifier
Positive	chromosome aberration	micronucleus assay	House mouse (as animal)	Not applicable	No resolvable identifier
Positive	chromosome aberration	micronucleus assay	Rat (as animal)	Not applicable	No resolvable identifier
Positive	DNA damage and/or repair	single cell gel/comet assay in mammalian cells for detection of DNA damage	House mouse (as animal)	Not applicable	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Koul, JL., Koul, SK., Taneja, SC., Dhar, KL. Oxygenated cyclohexanes from Piper cubeb. Phytochemistry, 1996, vol. 41, no. 4, p. 1097-1099. DOI
Bodiwala, Hardik S., Singh, Gaganmeet., Singh, Ranvir., Dey, Chinmoy Sankar., Sharma, Shyam Sundar., Bhutani, Kamlesh Kumar., Singh, Inder Pal. Antileishmanial amides and lignans from Piper cubeba and Piper retrofractum. JOURNAL OF NATURAL MEDICINES, 2007, vol. 61, no. 4, p. 418-421. DOI
Maistro, Edson Luis., Marcondes Natel, Andre Vinicius., Bianco de Souza, Gustavo Henrique., Perazzo, Fabio Ferreira. Genotoxic effects of (-)-cubebin in somatic cells of mice. Journal of applied toxicology, 2011, vol. 31, no. 2, p. 185-189. DOI
Freire Junqueira, Adriana Pereira., Perazzo, Fabio Ferreira., Blanco Souza, Gustavo Henrique., Maistro, Edson Luis. Clastogenicity of Piper cubeba (Piperaceae) seed extract in an in vivo mammalian cell system . Genetics and molecular biology, 2007, vol. 30, no. 3, p. 656-663.
Magalhaes, Lizandra G., de Souza, Julia M., Wakabayashi, Kamila A. L., Laurentiz, Rosangela da S., Vinholis, Adriana H. C., Rezende, Karen C. S., Simaro, Guilherme V., Bastos, Jairo K., Rodrigues, Vanderlei., Esperandim, Viviane R., Ferreira, Daniele S., Crotti, Antonio E. M., Cunha, Wilson R., Silva, Marcio L. A. E. In vitro efficacy of the essential oil of Piper cubeba L. (Piperaceae) against Schistosoma mansoni . Parasitology research, 2012, vol. 110, no. 5, p. 1747-1754. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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