Botanical species · safety record

Piper methysticum

The EFSA Compendium of Botanicals holds 15 constituent measurements, 6 adverse-effect records and 1 genotoxicity assay for Piper methysticum. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Piper methysticum G.Forst.

15Constituent measurements

7Safety records

7Cited sources

95Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 95 licensed products naming Piper methysticum as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Dry
Extract Type TBA
Fresh

Source material stated

Peeled rhizome
Piper methysticum - root
Rhizome
Rhizome(s)
Root
Root (standardized extract)
Whole plant

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
(+)-kavain	Roots and other underground parts used as staple food	Solvent extraction	11.46 Percent	GC-FID	Resolve DOI
(+)-methysticin	Roots and other underground parts used as staple food	Solvent extraction	10 Percent	GC-FID	Resolve DOI
Desmethoxyyangonin	Roots and other underground parts used as staple food	Solvent extraction	8.46 Percent	GC-FID	Resolve DOI
Dihydrokavain	Roots and other underground parts used as staple food	Solvent extraction	13.05 Percent	GC-FID	Resolve DOI
Dihydromethysticin	Roots and other underground parts used as staple food	Solvent extraction	11.36 Percent	GC-FID	Resolve DOI
Yangonin	Roots and other underground parts used as staple food	Solvent extraction	8.34 Percent	GC-FID	Resolve DOI
(+)-kavain	Roots and other underground parts used as staple food	—	—	Unspecified	No resolvable identifier
(+)-methysticin	Roots and other underground parts used as staple food	—	—	Unspecified	No resolvable identifier
Alkaloids	Leaves	Solvent extraction	—	Phytochemical screening	No resolvable identifier
Desmethoxyyangonin	Roots and other underground parts used as staple food	—	—	Unspecified	No resolvable identifier
Dihydrokavain	Roots and other underground parts used as staple food	—	—	Unspecified	No resolvable identifier
Dihydromethysticin	Roots and other underground parts used as staple food	—	—	Unspecified	No resolvable identifier
Saponins	Leaves	Solvent extraction	—	Phytochemical screening	No resolvable identifier
Tannins	Leaves	Solvent extraction	—	Phytochemical screening	No resolvable identifier
Yangonin	Roots and other underground parts used as staple food	—	—	Unspecified	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Neurotoxicity	Neurologic	Roots and other underground parts used as staple food	—	Human (as organism)	Case report	Resolve DOI
Neurotoxicity	Neurologic	Roots and other underground parts used as staple food	—	Human (as organism)	Case report	Resolve DOI
None	Neurologic	Roots and other underground parts used as staple food	—	Human (as organism)	Acute toxicity	Resolve DOI
Hepatotoxicity	Liver	Roots and other underground parts used as staple food	—	Human (as organism)	Case report	No resolvable identifier
Hepatotoxicity	Liver	Roots and other underground parts used as staple food	—	Human (as organism)	Case report	No resolvable identifier
Hepatotoxicity	Liver	Roots and other underground parts used as staple food	—	Human (as organism)	Case report	No resolvable identifier

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	—	other	Salmonella typhimurium (as organism)	—	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Abdualmjid, R.J., Sergi, C. Hepatotoxic botanicals - An evidence-based systematic review. Journal of pharmacy and pharmaceutical sciences, 2013, vol. 16, no. 3, p. 376-404.
Cairney, S., Maruff, P., Clough, AR., Collie, A., Currie, J., Currie, BJ. Saccade and cognitive impairment associated with kava intoxication. Human psychopharmacology-clinical and experimental, 2003, vol. 18, no. 7, p. 525-533. DOI
Chanwai, L.G. Kava toxicity. Emergency medicine, 2000, vol. 12, no. 2, p. 142-145. DOI
Jhoo, J. -W., Ang, C. Y. W., Heinze, T. M., Deck, J., Schnackenberg, L. K., Beger, R. D., Dragull, K., Tang, C. -S. Identification of C-glycoside flavonoids as potential mutagenic compounds in kava . Journal of food science, 2007, vol. 72, no. 2, p. C120-C125. DOI
Perez, J., Holmes, JF. Altered mental status and ataxia secondary to acute Kava ingestion. Journal of emergency medicine, 2005, vol. 28, no. 1, p. 49-51. DOI
Lim, Steven T. S., Dragull, Klaus., Tang, Chung-Shih., Bittenbender, Harry C., Efird, Jimmy T., Nerurkar, Pratibha V. Effects of kava alkaloid, pipermethystine, and kavalactones on oxidative stress and cytochrome P450 in F-344 rats . Toxicological sciences, 2007, vol. 97, no. 1, p. 214-221. DOI
Lestari, Martina Sri., Himawan, Toto., Abadi, A. Latif., Retnowati, Rurini. Toxicity and phytochemistry test of methanol extract of several plants from papua using Brine Shrimp Lethality Test (BSLT). Journal of chemical and pharmaceutical research, 2015, vol. 7, no. 4, p. 866-872.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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