Botanical species · safety record

Piper nigrum

The EFSA Compendium of Botanicals holds 4 constituent measurements for Piper nigrum. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Piper nigrum L.

4Constituent measurements

0Safety records

3Cited sources

1,186Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 1,186 licensed products naming Piper nigrum as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Dry
Extract Type TBA

Source material stated

Aged bark
Black Pepper - seed
Black pepper
Corn
Corn - standardised extract
Dried unripe berries
Fruit
Fruit (standardized extract)

What the records describe

Constituents measured

Plant parts

Preparations

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Piperine	Seed	Solvent extraction	—	GC-MS	Resolve DOI
Piperine	Fruit unspecified	Solvent extraction	133.8 Milligram/gram	UHPLC-MS-MS	Resolve DOI
Myristicin	Fruit unspecified	—	—	Unspecified	No resolvable identifier
Piperidine alkaloids	Fruit unspecified	—	—	Unspecified	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

WRBA, H., ELMOFTY, MM., SCHWAIREB, MH., DUTTER, A. CARCINOGENICITY TESTING OF SOME CONSTITUENTS OF BLACK PEPPER (PIPER-NIGRUM) . Experimental and toxicologic pathology, 1992, vol. 44, no. 2, p. 61-65.
Cardoso, Veronica da Silva., Vermelho, Alane Beatriz., Ribeiro de Lima, Cristina Amorim., de Oliveira, Jessica Mendes., Freire de Lima, Marco Edilson., Pinto da Silva, Lucia Helena., Direito, Gloria Maria., Miranda Danelli, Maria das Gracas. Antigenotoxic Effect of Piperine in Broiler Chickens Intoxicated with Aflatoxin B1 . Toxins, 2016, vol. 8, no. 11. DOI
Yoon, Yeo Cho., Kim, Sung-Hee., Kim, Min Jung., Yang, Hye Jeong., Rhyu, Mee-Ra., Park, Jae-Ho. Piperine, a component of black pepper, decreases eugenol-induced cAMP and calcium levels in non-chemosensory 3T3-L1 cells . Febs open bio, 2015, vol. 5, p. 20-25. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature