Botanical species · safety record

Piper retrofractum

The EFSA Compendium of Botanicals holds 10 constituent measurements and 3 adverse-effect records for Piper retrofractum. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Piper retrofractum Vahl

10Constituent measurements

3Safety records

7Cited sources

3Licensed products (Canada)

Also recorded as

Piper chaba Hunter

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 3 licensed products naming Piper retrofractum as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Source material stated

Seed
Stem

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Alkaloids	Fruit unspecified	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Lignans	Stem / stalk	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Myrcene	Leaves	Drying (dehydration)	14.4 Percent	GC-MS	Resolve DOI
Piperidine alkaloids	Roots and other underground parts	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Piperidine alkaloids	Stem / stalk	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Piperine	Fruit unspecified	Solvent extraction	31.08 Milligram/gram	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Piperine	Roots and other underground parts	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Piperlonguminine	Fruit unspecified	Solvent extraction	1.93 Milligram/gram	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Lignans	Fruit unspecified	Solvent extraction	—	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	No resolvable identifier
Lignans	Fruit unspecified	Solvent extraction	—	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Nephrotoxicity	Urogenital: kidneys	Fruit unspecified	Solvent extraction	Rat (as animal)	Subchronic	No resolvable identifier
Other toxicities	—	Fruit unspecified	Solvent extraction	Rat (as animal)	Subchronic	No resolvable identifier
Pulmonary and cardiac	Heart	Fruit unspecified	Solvent extraction	Rat (as animal)	Subchronic	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Bao, Narisu., Ochir, Sarangowa., Sun, Zhaorigetu., Borjihan, Gereltu., Yamagishi, Takashi. Occurrence of piperidine alkaloids in Piper species collected in different areas. JOURNAL OF NATURAL MEDICINES, 2014, vol. 68, no. 1, p. 211-214. DOI
Jaijoy, K., Vannasiri, S., Piyabhan, P., Lerdvuthisopon, N., Boonraeng, S., Khonsung, P., Lertprasertsuke, N., Sireeratawong, S. Acute and subchronic toxicity study of the water extract from the fruits of Piper chaba hunter in rats. International Journal of Applied Research in Natural Products, 2010, vol. 3, no. 4, p. 29-35.
Kubo, Miwa., Ishii, Rina., Ishino, Yoichi., Harada, Kenichi., Matsui, Nobuaki., Akagi, Masaaki., Kato, Eishin., Hosoda, Shinya., Fukuyama, Yoshiyasu. Evaluation of Constituents of Piper retrofractum Fruits on Neurotrophic Activity. JOURNAL OF NATURAL PRODUCTS, 2013, vol. 76, no. 4, p. 769-773. DOI
Bodiwala, Hardik S., Singh, Gaganmeet., Singh, Ranvir., Dey, Chinmoy Sankar., Sharma, Shyam Sundar., Bhutani, Kamlesh Kumar., Singh, Inder Pal. Antileishmanial amides and lignans from Piper cubeba and Piper retrofractum. JOURNAL OF NATURAL MEDICINES, 2007, vol. 61, no. 4, p. 418-421. DOI
Haribabu, Kothapalli., Ajitha, Makula., Mallavadhani, Uppuluri Venkata. Simultaneous determination of asaranin and sesamin in Piper chaba fruit by using HPTLC-MS method: effect of different extraction methods on the yield of marker compounds. Journal of Analytical Bioanalytical Techniques, 2014, p. 1000199/1-1000199/6.
Hieu, Le D., Thang, Tran D., Hoi, Tran M., Ogunwande, Isiaka A. Chemical Composition of Essential Oils from Four Vietnamese Species of Piper (Piperaceae) . Journal of oleo science, 2014, vol. 63, no. 3, p. 211-217. DOI
Rao, V. Rama Subba., Suresh, G., Babu, K. Suresh., Raju, S. Satyanarayana., Vardhan, M. V. P. S. Vishnu., Ramakrishna, Sistla., Rao, J. Madhusudana. Novel dimeric amide alkaloids from Piper chaba Hunter: isolation, cytotoxic activity, and their biomimetic synthesis . Tetrahedron, 2011, vol. 67, no. 10, p. 1885-1892. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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