Botanical species · safety record

Plumbago zeylanica

The EFSA Compendium of Botanicals holds 7 constituent measurements, 3 adverse-effect records and 3 genotoxicity assays for Plumbago zeylanica. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Plumbago zeylanica L.

7Constituent measurements

6Safety records

5Cited sources

22Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 22 licensed products naming Plumbago zeylanica as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Dry
Extract Type TBA

Source material stated

Root
Root bark
Whole plant

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Cardiac glycosides	Roots and other underground parts	Solvent extraction	—	Phytochemical screening	Resolve DOI
Coumarins	Roots and other underground parts	Solvent extraction	—	HPLC with standard detection methods	Resolve DOI
Naphthoquinones	Roots and other underground parts	Solvent extraction	—	HPLC with standard detection methods	Resolve DOI
Plumbagin	Roots and other underground parts	Solvent extraction	4 Percent	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	Resolve DOI
Plumbagin	Roots and other underground parts	Solvent extraction	80 Percent	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	Resolve DOI
Plumbagin	Roots and other underground parts	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Saponins	Roots and other underground parts	Solvent extraction	—	Phytochemical screening	Resolve DOI

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Hemopoietic	Cardiovascular / haematological	Unspecified	—	House mouse (as animal)	Short-term toxicity	Resolve DOI
Systemic	Liver	Roots and other underground parts	Solvent extraction	Rat (as animal)	Short-term toxicity	Resolve DOI
Systemic	Liver	Roots and other underground parts	Solvent extraction	Rat (as animal)	Acute toxicity	Resolve DOI

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	chromosome aberration	micronucleus assay	House mouse (as animal)	Not applicable	Resolve DOI
Not determined	DNA damage and/or repair	single cell gel/comet assay in mammalian cells for detection of DNA damage	House mouse (as animal)	—	Resolve DOI
Positive	DNA damage and/or repair	single cell gel/comet assay in mammalian cells for detection of DNA damage	House mouse (as animal)	—	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Demma, J., Engidawork, E., Hellmana, B. Potential genotoxicity of plant extracts used in Ethiopian traditional medicine . Journal of ethnopharmacology, 2009, vol. 122, no. 1, p. 136-142. DOI
SivaKumar, V., Prakash, R., Murali, MR., Devaraj, H., Devaraj, SN. In vivo micronucleus assay and GST activity in assessing genotoxicity of plumbagin in Swiss albino mice . Drug and chemical toxicology, 2005, vol. 28, no. 4, p. 499-507. DOI
Demma, Jemal., Hallberg, Karl., Hellman, Bjoern. Genotoxicity of plumbagin and its effects on catechol and NQNO-induced DNA damage in mouse lymphoma cells . Toxicology in vitro, 2009, vol. 23, no. 2, p. 266-271. DOI
Kumar, Dushyant., Patil, Paragouda A., Roy, Subarna., Kholkute, Sanjiv D., Hegde, Harsha V., Nair, Vinod. Comparative toxicity profiles of Plumbago zeylanica L. root petroleum ether, acetone and hydroalcoholic extracts in Wistar rats. . Ayu, 2015, vol. 36, no. 3, p. 329-34. DOI
Lin, LC., Yang, LL., Chou, CJ. Cytotoxic naphthoquinones and plumbagic acid glucosides from Plumbago zeylanica . Phytochemistry, 2003, vol. 62, no. 4, p. 619-622. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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