Botanical species · safety record

Prosopis juliflora

The EFSA Compendium of Botanicals holds 2 constituent measurements and 4 adverse-effect records for Prosopis juliflora. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Prosopis juliflora (Sw.) DC.

2Constituent measurements

4Safety records

6Cited sources

0Licensed products (Canada)

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Alkaloids	Leaves	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Piperidine alkaloids	Fruit unspecified	—	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Neurotoxicity	Neurologic	Fruit unspecified	Drying (dehydration)	Cattle (as animal)	Subchronic	Resolve DOI
Neurotoxicity	Neurologic: central nervous system	Unspecified	Fresh	Goat (as animal)	Case report	Resolve DOI
Neurotoxicity	Neurologic: central nervous system	Fruit unspecified	Solvent extraction	House mouse (as animal)	Acute toxicity	No resolvable identifier
Teratogenic	Urogenital	Fruit unspecified	Fresh	Rat (as animal)	Reproduction toxicity	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Silva, Victor Diogenes A., Pitanga, Bruno P. S., Nascimento, Ravena P., Souza, Cleide S., Coelho, Paulo Lucas C., Menezes-Filho, Noelio., Silva, Andre Mario M., Costa, Maria de Fatima D., El-Bacha, Ramon S., Velozo, Eudes S., Costa, Silvia L. Juliprosopine and Juliprosine from Prosopis juliflora Leaves Induce Mitochondrial Damage and Cytoplasmic Vacuolation on Cocultured Glial Cells and Neurons. CHEMICAL RESEARCH IN TOXICOLOGY, 2013, vol. 26, no. 12, p. 1810-1820. DOI
Tabosa, I. M., Riet-Correa, F., Barros, S. S., Summers, B. A., Simoes, S. V. D., Medeiros, R. M. T., Nobre, V. M. T. Neurohistologic and ultrastructural lesions in cattle experimentally intoxicated with the plant Prosopis juliflora. VETERINARY PATHOLOGY, 2006, vol. 43, no. 5, p. 695-701. DOI
Maioli, Marcos A., Lemos, Danilo E. C. V., Guelfi, Marieli., Medeiros, Hyllana C. D., Riet-Correa, Franklin., Medeiros, Rosane M. T., Barbosa-Filho, Jose M., Mingatto, Fabio E. Mechanism for the uncoupling of oxidative phosphorylation by juliprosopine on rat brain mitochondria. TOXICON, 2012, vol. 60, no. 8, p. 1355-1362. DOI
Medeiros, Marcia A., Riet-Correa, Franklin., Dantas, Francelicia P. M., Santos, Jose R. S., Medeiros, Rosane M. T. Teratogenic effects of Prosopis juliflora in rats and analysis of the toxicity of the pods . Pesquisa veterinaria brasileira, 2014, vol. 34, no. 11, p. 1089-1093.
Quintans-Junior, Lucindo Jose., Nobrega de Almeida, Reinaldo., Barbosa-Filho, Jose Maria., Duarte, Jose Crispim., Tabosa, Ivon Macedo. Acute toxicity and behavioral changes induced by the total alkaloid fraction of the pods of Prosopis juliflora (Sw) D.C. (Leguminoseae) in rodents. Acta farmaceutica bonaerense, 2004, p. 5-10.
Guedes, Karla M. R., Riet-Correa, Franklin., Dantas, Antonio Flavio M., Simoes, Sara V. D., Neto, Eldine G. Miranda., Nobre, Veronica M. T., Medeiros, Rosane M. T. Diseases of the central nervous system in goats and sheep of the semiarid . Pesquisa veterinaria brasileira, 2007, vol. 27, no. 1, p. 29-38. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature