Botanical species · safety record

Pteridium aquilinum

The EFSA Compendium of Botanicals holds 1 constituent measurement, 5 adverse-effect records and 3 genotoxicity assays for Pteridium aquilinum. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Pteridium aquilinum (L.) Kuhn.

1Constituent measurements

8Safety records

8Cited sources

0Licensed products (Canada)

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Ptaquiloside	Aerial part of plants	Solvent extraction	0.01 Percent	Chromatographic tests	Resolve DOI

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Nephrotoxicity	Urogenital: urinary bladder	Aerial part of plants	—	Animals (as animal)	Case report	Resolve DOI
Hemopoietic	—	Aerial part of plants	—	Cattle (as animal)	Case report	No resolvable identifier
Hemopoietic	Cardiovascular / haematological	Aerial part of plants	—	Cattle (as animal)	Case report	No resolvable identifier
Hemopoietic	Cardiovascular / haematological	Aerial part of plants	—	—	Case report	No resolvable identifier
Other toxicities	Urogenital: urinary bladder	—	Drying (dehydration)	Guinea pig (as animal)	Chronic/long term toxicity	No resolvable identifier

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	chromosome aberration	sister chromatid exchange assay in mammalian cells	Human (as organism)	—	Resolve DOI
Positive	DNA damage and/or repair	DNA damage and repair assay, unscheduled DNA synthesis in mammalian cells in vitro	House mouse (as animal)	—	Resolve DOI
Positive	—	bacterial gene mutation assay	Salmonella typhimurium (as organism)	No data	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Gil da Costa, Rui M., Coelho, Patricia., Sousa, Rosa., Bastos, Margarida M. S. M., Porto, Beatriz., Teixeira, Joao P., Malheiro, Isabel., Lopes, Carlos. Multiple genotoxic activities of ptaquiloside in human lymphocytes: Aneugenesis, clastogenesis and induction of sister chromatid exchange . Mutation research-genetic toxicology and environmental mutagenesis, 2012, vol. 747, no. 1, p. 77-81. DOI
Ramos G, Mariella., Chavera C, Alfonso., Tabacchi N, Luis., Huam�n U, H�ctor., Sandoval C, Nieves., Rodr�guez G, Jos�. LESIONES AN�TOMO-PATOL�GICAS EN CUYES INTOXICADOS EXPERIMENTALMENTE CON PTERIDIUM AQUILINUM COMO MODELO ANIMAL PARA BOVINOS CON HEMATURIA VESICAL ENZO�TICA BOVINA . Revista de investigaciones veterinarias del per�, 2012, vol. 23, no. 2, p. 201-208.
Gomes, Joana., Magalhaes, Ana., Michel, Valerie., Amado, Ines F., Aranha, Paulo., Ovesen, Rikke G., Hansen, Hans C. B., Gaertner, Fatima., Reis, Celso A., Touati, Eliette. Pteridium aquilinum and Its Ptaquiloside Toxin Induce DNA Damage Response in Gastric Epithelial Cells, a Link With Gastric Carcinogenesis . Toxicological sciences, 2012, vol. 126, no. 1, p. 60-71. DOI
Fukuoka, M., Kuroyanagi, M., Yoshihira, K., Natori, S., Nagao, M., Takahashi, Y., Sugimura, T. Chemical and toxicological studies on bracken fern, pteridium aquilinum var. Latiusculum. IV. Surveys on bracken constituents by mutagen test. Journal of pharmacobio-dynamics, 1978, vol. 1, no. 5, p. 324-331. DOI
Plessers, E., Pardon, B., Deprez, P., De Backer, P., Croubels, S. Acute hemorrhagic syndrome by bracken poisoning in cattle in Belgium. Vlaams diergeneeskundig tijdschrift, 2013, vol. 82, no. 1, p. 31-37.
Scala, Christopher., Ortiz, Katia., Catinaud, Jerome., Lemberger, Karin. HEMATURIA AND URINARY BLADDER LESIONS COMPATIBLE WITH BRACKEN FERN (PTERIDIUM AQUILINUM) INTOXICATION IN CAPTIVE FALLOW DEER (DAMA DAMA) . Journal of zoo and wildlife medicine, 2014, vol. 45, no. 2, p. 380-385. DOI
Gava, A., Neves, DD., Gava, D., Saliba, TD., Schild, AL., Riet-Correa, F. Bracken fern (Pteridium aquilinum) poisoning in cattle in southern Brazil . Veterinary and human toxicology, 2002, vol. 44, no. 6, p. 362-365.
Anjos, Bruno L., Irigoyen, Luiz F., Fighera, Rafael A., Gornes, Aline D., Kommers, Glaucia D., Barros, Claudio S. L. Acute poisoning by bracken fern (Pteridium aquilinum) in cattle in central Rio Grande do Sul, Brazil . Pesquisa veterinaria brasileira, 2008, vol. 28, no. 10, p. 501-507.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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