Botanical species · safety record

Pueraria candollei

The EFSA Compendium of Botanicals holds 24 constituent measurements, 6 adverse-effect records and 2 genotoxicity assays for Pueraria candollei. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Pueraria candollei Benth. var. mirifica (Airy Shaw & Suvat.) Niyomdham

24Constituent measurements

8Safety records

9Cited sources

12Licensed products (Canada)

Also recorded as

Pueraria mirifica Airy Shaw & Suvat.

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 12 licensed products naming Pueraria candollei as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Source material stated

Root
Whole plant

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Daidzein	Roots and other underground parts	Solvent extraction	≥ 19.4 Milligram/100 gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Daidzein	Roots and other underground parts	Solvent extraction	≤ 22.8 Milligram/100 gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Daidzin	Roots and other underground parts	Solvent extraction	≥ 34.9 Milligram/100 gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Daidzin	Roots and other underground parts	Solvent extraction	≤ 39.9 Milligram/100 gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Deoxymiroestrol	Roots and other underground parts used as staple food	Solvent extraction	≥ 0.0027 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Deoxymiroestrol	Roots and other underground parts used as staple food	Solvent extraction	≤ 0.0053 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Deoxymiroestrol	Roots and other underground parts	Solvent extraction	≤ 88.12 Microgram/gram	Enzyme-linked immunosorbent assay (ELISA)	Resolve DOI
Deoxymiroestrol	Roots and other underground parts	Solvent extraction	≥ 2.29 Microgram/gram	Enzyme-linked immunosorbent assay (ELISA)	Resolve DOI
Genistein	Roots and other underground parts	Solvent extraction	0.3 Milligram/100 gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Genistin	Roots and other underground parts used as staple food	Solvent extraction	≥ 7.6 Milligram/100 gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Genistin	Roots and other underground parts used as staple food	Solvent extraction	≤ 7.9 Milligram/100 gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Isoflavones	Roots and other underground parts	Solvent extraction	≥ 0.006 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Isoflavones	Roots and other underground parts	Solvent extraction	≤ 157.3 Milligram/100 gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Isoflavones	Roots and other underground parts	Solvent extraction	≤ 0.007 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Isoflavones	Roots and other underground parts	Solvent extraction	≥ 123.2 Milligram/100 gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Miroestrol	Roots and other underground parts used as staple food	Solvent extraction	≤ 0.0045 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Miroestrol	Roots and other underground parts used as staple food	Solvent extraction	≥ 0.0013 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Puerarin	Roots and other underground parts	Solvent extraction	≤ 86.5 Milligram/100 gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Puerarin	Roots and other underground parts	Solvent extraction	≥ 61 Milligram/100 gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Deoxymiroestrol	Roots and other underground parts	Solvent extraction	≤ 183 Microgram/gram	HPLC-UV	No resolvable identifier
Deoxymiroestrol	Roots and other underground parts	Solvent extraction	≥ 9.5 Microgram/gram	HPLC-UV	No resolvable identifier
Isoflavonoids	Roots and other underground parts	Solvent extraction	≤ 3.91 Microgram/gram	HPLC-UV	No resolvable identifier
Isoflavonoids	Roots and other underground parts	Solvent extraction	≥ 0.01 Microgram/gram	HPLC-UV	No resolvable identifier
Miroestrol	Roots and other underground parts	Solvent extraction	≤ 69.37 Microgram/gram	HPLC-UV	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Reproductive	Uterus	Roots and other underground parts	Drying (dehydration)	Rat (as animal)	Short-term toxicity	Resolve DOI
Reproductive	Urogenital	Roots and other underground parts used as staple food	Solvent extraction	House mouse (as animal)	Reproduction toxicity	Resolve DOI
Reproductive	Urogenital: ovaries	Roots and other underground parts used as staple food	Solvent extraction	House mouse (as animal)	Reproduction toxicity	Resolve DOI
Hemopoietic	Cardiovascular / haematological	Roots and other underground parts used as staple food	Solvent extraction	Rat (as animal)	Short-term toxicity	No resolvable identifier
Hemopoietic	Cardiovascular / haematological	Roots and other underground parts used as staple food	Solvent extraction	Rat (as animal)	Short-term toxicity	No resolvable identifier
Hepatotoxicity	Urogenital: kidneys	Roots and other underground parts used as staple food	Solvent extraction	Rat (as animal)	Short-term toxicity	No resolvable identifier

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	chromosome aberration	micronucleus assay	Rat (as animal)	Not applicable	No resolvable identifier
Positive	chromosome aberration	micronucleus assay	Rat (as animal)	—	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Urasopon, Nontakorn., Hamada, Yuzuru., Asaoka, Kazuo., Poungmali, Ubon., Malaivijitnond, Suchinda. Isoflavone content of rodent diets and its estrogenic effect on vaginal cornification in Pueraria mirifica-treated rats . Scienceasia, 2008, vol. 34, no. 4, p. 371-376. DOI
Saenphet, K., Kantaoop, P., Saenphet, S., Aritajat, S. Mutagenicity of Pueraria mirifica Airy Shaw & Suvatabandhu and antimutagenicity of Thunbergia laurifolia Linn. . The southeast asian journal of tropical medicine and public health, 2005, vol. 36 Suppl 4, p. 238-41.
Yusakul, Gorawit., Putalun, Waraporn., Udomsin, Orapin., Juengwatanatrakul, Thaweesak., Chaichantipyuth, Chaiyo. Comparative analysis of the chemical constituents of two varieties of Pueraria candollei. Fitoterapia, 2011, vol. 82, no. 2, p. 203-207.
Shimokawa, Satoko., Kumamoto, Takuya., Ishikawa, Tsutomu., Takashi, Miho., Higuchi, Yoshihiro., Chaichantipyuth, Chaiyo., Chansakaow, Sunee. Quantitative analysis of miroestrol and kwakhurin for standardisation of Thai miracle herb Kwao Keur' (Pueraria mirifica) and establishment of simple isolation procedure for highly estrogenic miroestrol and deoxymiroestrol . Natural product research, 2013, vol. 27, no. 4-5, p. 371-378. DOI
Sanchanta, P., Saenphet, K., Saenphet, S., Aritajat, S., Wongsawad, C., Brovelli, E., Chansakaow, S., Farias, D., Hongratanaworakit, T., Omary, MB., Vejabhikul, S. Toxicological study of aqueous and ethanolic extracts from Pueraria mirifica Airy Shaw & Suvatabandhu on male rats . Wocmap iii: quality, efficacy, safety, processing and trade in maps, 2005, no. 679, p. 165-171.
Jaroenporn, Sukanya., Malaivijitnond, Suchinda., Wattanasirmkit, Kingkaew., Trisomboon, Hataitip., Watanabe, Gen., Taya, Kazuyoshi., Cherdshewasart, Wichai. Effects of Pueraria mirifica, an herb containing phytoestrogens, on reproductive organs and fertility of adult male mice . Endocrine, 2006, vol. 30, no. 1, p. 93-101. DOI
Gomuttapong, Sarawoot., Pewphong, Rangsima., Choeisiri, Sucha., Jaroenporn, Sukanya., Malaivijitnond, Suchinda. Testing of the estrogenic activity and toxicity of Stephania venosa herb in ovariectomized rats . Toxicology mechanisms and methods, 2012, vol. 22, no. 6, p. 445-457. DOI
Jaroenporn, Sukanya., Malaivijitnond, Suchinda., Wattanasirmkit, Kingkaew., Watanabe, Gen., Taya, Kazuyoshi., Cherdshewasart, Wichai. Assessment of fertility and reproductive toxicity in adult female mice after long-term exposure to Pueraria mirifica herb . Journal of reproduction and development, 2007, vol. 53, no. 5, p. 995-1005. DOI
Yusakul, Gorawit., Udomsin, Orapin., Juengwatanatrakul, Thaweesak., Tanaka, Hiroyuki., Chaichantipyuth, Chaiyo., Putalun, Waraporn. Highly selective and sensitive determination of deoxymiroestrol using a polyclonal antibody-based enzyme-linked immunosorbent assay . Talanta, 2013, vol. 114, p. 73-78. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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