Botanical species · safety record
Pueraria montana
The EFSA Compendium of Botanicals holds 41 constituent measurements and 2 adverse-effect records for Pueraria montana. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.
Accepted name in source: Pueraria montana var. lobata (Willd.) Sanjappa & Pradeep
Also recorded as
Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.
Regulatory presence
Health Canada's Licensed Natural Health Products Database holds 8 licensed products naming Pueraria montana as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.
Extract types on licence
Source material stated
What the records describe
Constituents measured
- Isoflavones7
- Daidzin5
- Puerarin5
- Daidzein4
- Genistein4
- Genistin4
- Glycitein2
- Glycitin2
- Harman2
- Norharmane2
Plant parts
- Flower15
- Roots and other underground parts9
- Aerial part of plants5
- Roots and other underground parts used as staple food5
- Seed5
- Unspecified4
Preparations
- Solvent extraction43
Effect types
- Endocrine1
- Hepatotoxicity1
Target tissues
- Liver1
Recorded constituents
What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.
| Substance | Plant part | Preparation | Concentration | Analytical method | Source |
|---|---|---|---|---|---|
| Daidzein | Seed | Solvent extraction | 1.687 Milligram/gram | HPLC with standard detection methods | Resolve DOI |
| Daidzein | Aerial part of plants | Solvent extraction | 2.485 Milligram/gram | HPLC with standard detection methods | Resolve DOI |
| Daidzin | Roots and other underground parts | Solvent extraction | 4.685 Milligram/gram | HPLC with standard detection methods | Resolve DOI |
| Daidzin | Seed | Solvent extraction | 0.525 Milligram/gram | HPLC with standard detection methods | Resolve DOI |
| Daidzin | Aerial part of plants | Solvent extraction | 0.404 Milligram/gram | HPLC with standard detection methods | Resolve DOI |
| Genistein | Aerial part of plants | Solvent extraction | 0.255 Milligram/gram | HPLC with standard detection methods | Resolve DOI |
| Genistein | Roots and other underground parts | Solvent extraction | 0.561 Milligram/gram | HPLC with standard detection methods | Resolve DOI |
| Genistein | Seed | Solvent extraction | 0.019 Milligram/gram | HPLC with standard detection methods | Resolve DOI |
| Genistin | Aerial part of plants | Solvent extraction | 1.123 Milligram/gram | HPLC with standard detection methods | Resolve DOI |
| Genistin | Seed | Solvent extraction | 0.145 Milligram/gram | HPLC with standard detection methods | Resolve DOI |
| Genistin | Roots and other underground parts | Solvent extraction | 3.248 Milligram/gram | HPLC with standard detection methods | Resolve DOI |
| Glycitein | Flower | Solvent extraction | ≤ 0.54 Percent | HPLC-ELSD | Resolve DOI |
| Glycitin | Flower | Solvent extraction | ≤ 1.4 Percent | HPLC-ELSD | Resolve DOI |
| Isoflavones | Flower | Solvent extraction | ≥ 1.3 Percent | HPLC-ELSD | Resolve DOI |
| Isoflavones | Flower | Solvent extraction | ≤ 8.69 Percent | HPLC-ELSD | Resolve DOI |
| Pentacyclic triterpene saponins | Flower | Solvent extraction | ≤ 2.75 Percent | HPLC-ELSD | Resolve DOI |
| Puerarin | Aerial part of plants | Solvent extraction | 1.674 Milligram/gram | HPLC with standard detection methods | Resolve DOI |
| Puerarin | Roots and other underground parts | Solvent extraction | 20.899 Milligram/gram | HPLC with standard detection methods | Resolve DOI |
| Puerarin | Seed | Solvent extraction | 1.187 Milligram/gram | HPLC with standard detection methods | Resolve DOI |
| Tectorigenin | Flower | Solvent extraction | ≤ 1.08 Percent | HPLC-ELSD | Resolve DOI |
| Daidzein | Roots and other underground parts used as staple food | Solvent extraction | 10.34 Milligram/100 gram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | No resolvable identifier |
| Daidzein | Roots and other underground parts | Solvent extraction | 0.19 Milligram/gram | Capillary (Zone) Electrophoresis (CE or CZE) | No resolvable identifier |
| Daidzin | Roots and other underground parts used as staple food | Solvent extraction | 21.9 Milligram/100 gram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | No resolvable identifier |
| Daidzin | Roots and other underground parts | Solvent extraction | 0.2 Milligram/gram | Capillary (Zone) Electrophoresis (CE or CZE) | No resolvable identifier |
| Genistein | Roots and other underground parts used as staple food | Solvent extraction | 0.81 Milligram/100 gram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | No resolvable identifier |
| Genistin | Roots and other underground parts used as staple food | Solvent extraction | 25.63 Milligram/100 gram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | No resolvable identifier |
| Glycitein | Flower | Solvent extraction | — | Nuclear Magnetic Resonance (NMR) | No resolvable identifier |
| Glycitin | Flower | Solvent extraction | — | Nuclear Magnetic Resonance (NMR) | No resolvable identifier |
| Harman | Unspecified | Solvent extraction | ≥ 61 Nanogram/gram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | No resolvable identifier |
| Harman | Unspecified | Solvent extraction | ≤ 168 Nanogram/gram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | No resolvable identifier |
| Isoflavones | Flower | Solvent extraction | ≥ 10 Milligram/gram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | No resolvable identifier |
| Isoflavones | Flower | Solvent extraction | ≥ 11.08 Milligram/gram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | No resolvable identifier |
| Isoflavones | Flower | Solvent extraction | ≤ 48.23 Milligram/gram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | No resolvable identifier |
| Isoflavones | Flower | Solvent extraction | — | Nuclear Magnetic Resonance (NMR) | No resolvable identifier |
| Isoflavones | Flower | Solvent extraction | ≤ 43.28 Milligram/gram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | No resolvable identifier |
| Norharmane | Unspecified | Solvent extraction | ≤ 313 Nanogram/gram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | No resolvable identifier |
| Norharmane | Unspecified | Solvent extraction | ≥ 200 Nanogram/gram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | No resolvable identifier |
| Pentacyclic triterpene saponins | Flower | Solvent extraction | — | Nuclear Magnetic Resonance (NMR) | No resolvable identifier |
| Puerarin | Roots and other underground parts used as staple food | Solvent extraction | 32.85 Milligram/100 gram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | No resolvable identifier |
| Puerarin | Roots and other underground parts | Solvent extraction | 1.08 Milligram/gram | Capillary (Zone) Electrophoresis (CE or CZE) | No resolvable identifier |
40 of 41 records are shown, ordered so that records carrying a resolvable reference come first.
Recorded adverse effects
Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.
| Effect | Target tissue | Plant part | Preparation | Test organism | Test type | Source |
|---|---|---|---|---|---|---|
| Endocrine | — | Roots and other underground parts | Solvent extraction | — | In vitro | No resolvable identifier |
| Hepatotoxicity | Liver | Roots and other underground parts | Solvent extraction | Rat (as animal) | Short-term toxicity | No resolvable identifier |
Cited sources
The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.
- Tsuchiya, Hironori., Hayashi, Hideaki., Sato, Masaru., Shimizu, Hiroshi., Iinuma, Munekazu. Quantitative analysis of all types of beta-carboline alkaloids in medicinal plants and dried edible plants by high performance liquid chromatography with selective fluorometric detection. Phytochemical Analysis, 1999, p. 247-253.
- Yao, Meicun., Liao, Yiting., Li, George Q., Law, Francis C. P., Tang, Yi. Quantitative analysis of 2 isoflavones in Pueraria lobata flowers from11 Chinese provinces usingHPLCaphy. Chinese medicine, 2010.
- Park, Kun-Young., Jung, Geun-Ok., Choi, Jongwon., Lee, Kyung-Tae., Park, Hee-Juhn. Potent antimutagenic and their anti-lipid peroxidative effect of kaikasaponin III and tectorigenin from the flower of Pueraria thunbergiana. Archives of pharmacal research, 2002, p. 320-324.
- Cherdshewasart, W., Sutjit, W., Pulcharoen, K., Chulasiri, M. The mutagenic and antimutagenic effects of the traditional phytoestrogen-rich herbs, Pueraria mirifica and Pueraria lobata . Brazilian journal of medical and biological research, 2009, vol. 42, no. 9, p. 816-823.
- Wang Dengyuan., Qiu Liang., Wu Xiaoli., Wei Hua., Xu Feng. Evaluation of kudzu root extract-induced hepatotoxicity. Journal of ethnopharmacology, 2015, p. 321-326.
- Kayano, S.-I., Matsumura, Y., Kitagawa, Y., Kobayashi, M., Nagayama, A., Kawabata, N., Tuchida, M., Usuki, M., Kikuzaki, H., Kitada, Y. Isoflavone C-glycosides isolated from the root of kudzu (Pueraria Lobata) and their estrogenic and antimutagenic activities. Recent advances in ginseng and glycosides research, 2013, p. 103-118.
- Kirakosyan, A., Kaufman, PB., Warber, S., Bolling, S., Chang, SC., Duke, JA. Quantification of major isoflavonoids and L-canavanine in several organs of kudzu vine (Pueraria montana) and in starch samples derived from kudzu roots . Plant science, 2003, vol. 164, no. 5, p. 883-888. DOI
- Xiao, Wen., Wang, Feng-Qin., Li, Chun-Hong., Zhang, Qian., Xia, Zhi-Ning., Yang, Feng-Qing. Determination of eight isoflavones in Radix Puerariae by capillary zone electrophoresis with an ionic liquid as an additive. Analytical methods, 2015, p. 1098-1103.
- Niiho, Yujiro., Nakajima, Yoshijiro., Yamazaki, Takashi., Okamoto, Mitsuru., Tsuchihashi, Ryota., Kodera, Mitsuru., Kinjo, Junei., Nohara, Toshihiro. Simultaneous analysis of isoflavones and saponins in Pueraria flowers using HPLC coupled to an evaporative light scattering detector and isolation of a new isoflavone diglucoside. JOURNAL OF NATURAL MEDICINES, 2010, vol. 64, no. 3, p. 313-320. DOI
Boundary
A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.
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