Botanical species · safety record

Pueraria montana

The EFSA Compendium of Botanicals holds 41 constituent measurements and 2 adverse-effect records for Pueraria montana. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Pueraria montana var. lobata (Willd.) Sanjappa & Pradeep

41Constituent measurements
2Safety records
9Cited sources
8Licensed products (Canada)

Also recorded as

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 8 licensed products naming Pueraria montana as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

  • Dry

Source material stated

  • Flower
  • Root

What the records describe

Constituents measured

  • Isoflavones7
  • Daidzin5
  • Puerarin5
  • Daidzein4
  • Genistein4
  • Genistin4
  • Glycitein2
  • Glycitin2
  • Harman2
  • Norharmane2

Plant parts

  • Flower15
  • Roots and other underground parts9
  • Aerial part of plants5
  • Roots and other underground parts used as staple food5
  • Seed5
  • Unspecified4

Preparations

  • Solvent extraction43

Effect types

  • Endocrine1
  • Hepatotoxicity1

Target tissues

  • Liver1

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

SubstancePlant partPreparationConcentrationAnalytical methodSource
DaidzeinSeedSolvent extraction1.687 Milligram/gramHPLC with standard detection methodsResolve DOI
DaidzeinAerial part of plantsSolvent extraction2.485 Milligram/gramHPLC with standard detection methodsResolve DOI
DaidzinRoots and other underground partsSolvent extraction4.685 Milligram/gramHPLC with standard detection methodsResolve DOI
DaidzinSeedSolvent extraction0.525 Milligram/gramHPLC with standard detection methodsResolve DOI
DaidzinAerial part of plantsSolvent extraction0.404 Milligram/gramHPLC with standard detection methodsResolve DOI
GenisteinAerial part of plantsSolvent extraction0.255 Milligram/gramHPLC with standard detection methodsResolve DOI
GenisteinRoots and other underground partsSolvent extraction0.561 Milligram/gramHPLC with standard detection methodsResolve DOI
GenisteinSeedSolvent extraction0.019 Milligram/gramHPLC with standard detection methodsResolve DOI
GenistinAerial part of plantsSolvent extraction1.123 Milligram/gramHPLC with standard detection methodsResolve DOI
GenistinSeedSolvent extraction0.145 Milligram/gramHPLC with standard detection methodsResolve DOI
GenistinRoots and other underground partsSolvent extraction3.248 Milligram/gramHPLC with standard detection methodsResolve DOI
GlyciteinFlowerSolvent extraction≤ 0.54 PercentHPLC-ELSDResolve DOI
GlycitinFlowerSolvent extraction≤ 1.4 PercentHPLC-ELSDResolve DOI
IsoflavonesFlowerSolvent extraction≥ 1.3 PercentHPLC-ELSDResolve DOI
IsoflavonesFlowerSolvent extraction≤ 8.69 PercentHPLC-ELSDResolve DOI
Pentacyclic triterpene saponinsFlowerSolvent extraction≤ 2.75 PercentHPLC-ELSDResolve DOI
PuerarinAerial part of plantsSolvent extraction1.674 Milligram/gramHPLC with standard detection methodsResolve DOI
PuerarinRoots and other underground partsSolvent extraction20.899 Milligram/gramHPLC with standard detection methodsResolve DOI
PuerarinSeedSolvent extraction1.187 Milligram/gramHPLC with standard detection methodsResolve DOI
TectorigeninFlowerSolvent extraction≤ 1.08 PercentHPLC-ELSDResolve DOI
DaidzeinRoots and other underground parts used as staple foodSolvent extraction10.34 Milligram/100 gramHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)No resolvable identifier
DaidzeinRoots and other underground partsSolvent extraction0.19 Milligram/gramCapillary (Zone) Electrophoresis (CE or CZE)No resolvable identifier
DaidzinRoots and other underground parts used as staple foodSolvent extraction21.9 Milligram/100 gramHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)No resolvable identifier
DaidzinRoots and other underground partsSolvent extraction0.2 Milligram/gramCapillary (Zone) Electrophoresis (CE or CZE)No resolvable identifier
GenisteinRoots and other underground parts used as staple foodSolvent extraction0.81 Milligram/100 gramHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)No resolvable identifier
GenistinRoots and other underground parts used as staple foodSolvent extraction25.63 Milligram/100 gramHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)No resolvable identifier
GlyciteinFlowerSolvent extractionNuclear Magnetic Resonance (NMR)No resolvable identifier
GlycitinFlowerSolvent extractionNuclear Magnetic Resonance (NMR)No resolvable identifier
HarmanUnspecifiedSolvent extraction≥ 61 Nanogram/gramHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)No resolvable identifier
HarmanUnspecifiedSolvent extraction≤ 168 Nanogram/gramHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)No resolvable identifier
IsoflavonesFlowerSolvent extraction≥ 10 Milligram/gramHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)No resolvable identifier
IsoflavonesFlowerSolvent extraction≥ 11.08 Milligram/gramHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)No resolvable identifier
IsoflavonesFlowerSolvent extraction≤ 48.23 Milligram/gramHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)No resolvable identifier
IsoflavonesFlowerSolvent extractionNuclear Magnetic Resonance (NMR)No resolvable identifier
IsoflavonesFlowerSolvent extraction≤ 43.28 Milligram/gramHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)No resolvable identifier
NorharmaneUnspecifiedSolvent extraction≤ 313 Nanogram/gramHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)No resolvable identifier
NorharmaneUnspecifiedSolvent extraction≥ 200 Nanogram/gramHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)No resolvable identifier
Pentacyclic triterpene saponinsFlowerSolvent extractionNuclear Magnetic Resonance (NMR)No resolvable identifier
PuerarinRoots and other underground parts used as staple foodSolvent extraction32.85 Milligram/100 gramHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)No resolvable identifier
PuerarinRoots and other underground partsSolvent extraction1.08 Milligram/gramCapillary (Zone) Electrophoresis (CE or CZE)No resolvable identifier

40 of 41 records are shown, ordered so that records carrying a resolvable reference come first.

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

EffectTarget tissuePlant partPreparationTest organismTest typeSource
EndocrineRoots and other underground partsSolvent extractionIn vitroNo resolvable identifier
HepatotoxicityLiverRoots and other underground partsSolvent extractionRat (as animal)Short-term toxicityNo resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

  1. Tsuchiya, Hironori., Hayashi, Hideaki., Sato, Masaru., Shimizu, Hiroshi., Iinuma, Munekazu. Quantitative analysis of all types of beta-carboline alkaloids in medicinal plants and dried edible plants by high performance liquid chromatography with selective fluorometric detection. Phytochemical Analysis, 1999, p. 247-253.
  2. Yao, Meicun., Liao, Yiting., Li, George Q., Law, Francis C. P., Tang, Yi. Quantitative analysis of 2 isoflavones in Pueraria lobata flowers from11 Chinese provinces usingHPLCaphy. Chinese medicine, 2010.
  3. Park, Kun-Young., Jung, Geun-Ok., Choi, Jongwon., Lee, Kyung-Tae., Park, Hee-Juhn. Potent antimutagenic and their anti-lipid peroxidative effect of kaikasaponin III and tectorigenin from the flower of Pueraria thunbergiana. Archives of pharmacal research, 2002, p. 320-324.
  4. Cherdshewasart, W., Sutjit, W., Pulcharoen, K., Chulasiri, M. The mutagenic and antimutagenic effects of the traditional phytoestrogen-rich herbs, Pueraria mirifica and Pueraria lobata . Brazilian journal of medical and biological research, 2009, vol. 42, no. 9, p. 816-823.
  5. Wang Dengyuan., Qiu Liang., Wu Xiaoli., Wei Hua., Xu Feng. Evaluation of kudzu root extract-induced hepatotoxicity. Journal of ethnopharmacology, 2015, p. 321-326.
  6. Kayano, S.-I., Matsumura, Y., Kitagawa, Y., Kobayashi, M., Nagayama, A., Kawabata, N., Tuchida, M., Usuki, M., Kikuzaki, H., Kitada, Y. Isoflavone C-glycosides isolated from the root of kudzu (Pueraria Lobata) and their estrogenic and antimutagenic activities. Recent advances in ginseng and glycosides research, 2013, p. 103-118.
  7. Kirakosyan, A., Kaufman, PB., Warber, S., Bolling, S., Chang, SC., Duke, JA. Quantification of major isoflavonoids and L-canavanine in several organs of kudzu vine (Pueraria montana) and in starch samples derived from kudzu roots . Plant science, 2003, vol. 164, no. 5, p. 883-888. DOI
  8. Xiao, Wen., Wang, Feng-Qin., Li, Chun-Hong., Zhang, Qian., Xia, Zhi-Ning., Yang, Feng-Qing. Determination of eight isoflavones in Radix Puerariae by capillary zone electrophoresis with an ionic liquid as an additive. Analytical methods, 2015, p. 1098-1103.
  9. Niiho, Yujiro., Nakajima, Yoshijiro., Yamazaki, Takashi., Okamoto, Mitsuru., Tsuchihashi, Ryota., Kodera, Mitsuru., Kinjo, Junei., Nohara, Toshihiro. Simultaneous analysis of isoflavones and saponins in Pueraria flowers using HPLC coupled to an evaporative light scattering detector and isolation of a new isoflavone diglucoside. JOURNAL OF NATURAL MEDICINES, 2010, vol. 64, no. 3, p. 313-320. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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