Botanical species · safety record

Pueraria tuberosa

The EFSA Compendium of Botanicals holds 11 constituent measurements and 6 adverse-effect records for Pueraria tuberosa. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Pueraria tuberosa (Willd.) DC.

11Constituent measurements

6Safety records

11Cited sources

13Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 13 licensed products naming Pueraria tuberosa as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Source material stated

Root
Root tuber(s)
Tuber

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Daidzein	Roots and other underground parts used as staple food	Solvent extraction	68.7 Milligram/gram	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	Resolve DOI
Genistein	Roots and other underground parts used as staple food	Solvent extraction	55.7 Milligram/container	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	Resolve DOI
Puerarin	Roots and other underground parts	Solvent extraction	9.28 Percent	HPLC-UV	Resolve DOI
Puerarin	Roots and other underground parts used as staple food	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Alkaloids	Roots and other underground parts	Solvent extraction	—	Phytochemical screening	No resolvable identifier
Daidzein	Roots and other underground parts	Solvent extraction	1.7 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Genistein	Roots and other underground parts	Solvent extraction	1.37 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Puerarin	Roots and other underground parts	Solvent extraction	8.31 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Puerarin	Roots and other underground parts	Solvent extraction	2.45 Percent	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	No resolvable identifier
Saponins	Roots and other underground parts	Solvent extraction	—	Phytochemical screening	No resolvable identifier
Tannic acid	Roots and other underground parts used as staple food	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Hepatotoxicity	Liver	Roots and other underground parts used as staple food	Solvent extraction	Rat (as animal)	Short-term toxicity	Resolve DOI
Other toxicities	Glandular: thyroid	Roots and other underground parts used as staple food	Solvent extraction	Rat (as animal)	Acute toxicity	Resolve DOI
Reproductive	—	Roots and other underground parts	Solvent extraction	Rat (as animal)	Reproduction toxicity	Resolve DOI
Reproductive	Urogenital	Roots and other underground parts	Solvent extraction	Rat (as animal)	Reproduction toxicity	Resolve DOI
Reproductive	Uterus	Roots and other underground parts used as staple food	Solvent extraction	Rat (as animal)	Reproduction toxicity	Resolve DOI
Systemic	Urogenital: kidneys	Unspecified	Solvent extraction	Rat (as animal)	Short-term toxicity	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Santosh, Nagwani., Mohan, Kumar., Royana, Singh., Yamini, Tripathi B. Hepatotoxicity of tubers of Indian Kudzu (Pueraria tuberosa) in rats. Food and chemical toxicology, 2010, vol. 48, no. 4, p. 1066-1071. DOI
Shukla, S. Toxicological studies of Pueraria tuberosa, a potent antifertility plant. International journal of pharmacognosy, 1995, vol. 33, no. 4, p. 324-329.
Saha, Piyali., Saraswat, Ghungroo., Chakraborty, Pratip., Banerjee, Sayani., Pal, Bikas C., Kabir, Syed N. Puerarin, a selective oestrogen receptor modulator, disrupts pregnancy in rats at pre-implantation stage . Reproduction, 2012, vol. 144, no. 5, p. 633-645. DOI
Shilpashree, V. K., Dang, Raman., Das, Kuntal. Evaluation of phytochemical investigation and immunomodulatory activity of four different plant species of vidari by carbon clearance test on wister rats. Annals of phytomedicine, 2015, vol. 4, no. 1, p. 94-98.
Chauhan, Nagendra Singh., Sharma, Vikas., Thakur, Mayank., Christine Helena Frankland Sawaya, Alexandra., Dixit, V K. Pueraria tuberosa DC extract improves androgenesis and sexual behavior via FSH LH cascade. . Thescientificworldjournal, 2013, vol. 2013, p. 780659. DOI
Gupta, RS., Sharma, R., Sharma, A., Choudhary, R., Bhatnager, AK., Joshi, YC. Antifertility effects of Pueraria tuberosa root extract in male rats. Pharmaceutical biology, 2004, vol. 42, no. 8, p. 603-609. DOI
Maji, A.K., Mahapatra, S., Banerjee, D. In-vivo immunomodulatory potential of standardized pueraria tuberosa extract and its isoflavonoids. International journal of pharmacy and pharmaceutical sciences, 2014, vol. 6, no. 1, p. 861-867.
Durgawale, T.P., Durgawale, P.P., Khanwelkar, C.C. Quantitative estimation of tannins by HPLC. Der pharmacia lettre, 2016, vol. 8, no. 3, p. 123-126.
Satpathy, Swaha., Patra, Arjun., Hussain, M. Delwar., Ahirwar, Bharti. Simultaneous estimation of genistein and daidzein in Pueraria tuberosa (Willd.) DC by validated high-performance thin-layer chromatography (HPTLC) densitometry method . Journal of liquid chromatography & related technologies, 2017, vol. 40, no. 10, p. 499-505. DOI
Maji, Amal K., Maity, Niladri., Banerji, Pratim., Banerjee, Debdulal. A validated RP-HPLC-UV method for quantitative determination of puerarin in Pueraria tuberosa DC tuber extract. . Pharmaceutical methods, 2012, vol. 3, no. 2, p. 79-83. DOI
Mhaske, Harshad P., Vaidya, Vikas V., Kekare, Maharudra B., Champanerkar, Parikshit A., Parekh, Sagar A. Quantification of beta-Sitosterol and Puerarin from Pueraria tuberosa DC. by Using High Performance Thin Layer Chromatography . Asian journal of chemistry, 2009, vol. 21, no. 5, p. 3449-3454.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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