Botanical species · safety record

Punica granatum

The EFSA Compendium of Botanicals holds 9 constituent measurements and 3 genotoxicity assays for Punica granatum. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Punica granatum L.

9Constituent measurements

3Safety records

5Cited sources

1,060Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 1,060 licensed products naming Punica granatum as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Dry
Extract Type TBA
Fresh

Source material stated

Fruit
Fruit (standardized extract)
Fruit Hull
Fruit Juice
Fruit extract
Fruit peel
Fruit pericarp
Fruit skin

What the records describe

Constituents measured

Plant parts

Preparations

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Alkaloids	Seed	Solvent extraction	—	Phytochemical screening	Resolve DOI
Ellagitannins (hydrolysable tannins)	Flower	Solvent extraction	—	Chromatographic tests	Resolve DOI
Gallic acid	Fruit peel	Solvent extraction	≤ 2.71 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Gallic acid	Fruit peel	Solvent extraction	≥ 1.36 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Pelletierine	Fruit unspecified	—	—	Mass Spectroscopy and hyphenated methods without chromatography	Resolve DOI
Pseudopelletierine	Fruit unspecified	—	—	Mass Spectroscopy and hyphenated methods without chromatography	Resolve DOI
Pyridine alkaloids	Fruit unspecified	—	—	Mass Spectroscopy and hyphenated methods without chromatography	Resolve DOI
Saponins	Seed	Solvent extraction	—	Phytochemical screening	Resolve DOI
Tannins	Seed	Solvent extraction	—	Phytochemical screening	Resolve DOI

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	gene mutation	mitotic recombination in Saccharomyces cerevisiae	Saccharomyces cerevisiae (as organism)	With and without	Resolve DOI
Positive	gene mutation	bacterial reverse mutation assay	Salmonella typhimurium (as organism)	With and without	Resolve DOI
Positive	chromosome aberration	in vitro mammalian chromosome aberration test	Other	Without	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Sanchez-Lamar, Angel., Fonseca, Gladys., Fuentes, Jorge Luis., Cozzi, Renata., Cundari, Enrico., Fiore, Mario., Ricordy, Ruggero., Perticone, Paolo., Degrassi, Francesca., De Salvia, Rosella. Assessment of the genotoxic risk of Punica granatum L. (Punicaceae) whole fruit extracts. Journal of ethnopharmacology, 2008, vol. 115, no. 3, p. 416-422. DOI
Mehrzadi, Saeed., Sadr, Samira., Hosseinzadeh, Azam., Gholamine, Babak., Shahbazi, Ali., FallahHuseini, Hasan., Ghaznavi, Habib. Anticonvulsant activity of the ethanolic extract of Punica granatum L. seed. Neurological research, 2015, vol. 37, no. 6, p. 470-475. DOI
Chang, Qing., Peng, Yue'e., Dan, Conghui., Shuai, Qin., Hu, Shenghong. Rapid in Situ Identification of Bioactive Compounds in Plants by in Vivo Nanospray High-Resolution Mass Spectrometry. Journal of agricultural and food chemistry, 2015, vol. 63, no. 11, p. 2911-2918. DOI
Kuhn, Andrielle Wouters., Tedesco, Marilia., Boligon, Aline Augusti., Athayde, Margareth Linde., Laughinghouse, Haywood Dail., Tedesco, Solange Bosio. Chromatographic analysis and antiproliferative potential of aqueous extracts of Punica granatum fruit peels using the Allium cepa test. Brazilian journal of pharmaceutical sciences, 2015, vol. 51, no. 1, p. 241-248. DOI
Yuan, Tao., Ding, Yuanqing., Wan, Chunpeng., Li, Liya., Xu, Jialin., Liu, Ke., Slitt, Angela., Ferreira, Daneel., Khan, Ikhlas A., Seeram, Navindra P. Antidiabetic Ellagitannins from Pomegranate Flowers: Inhibition of alpha-Glucosidase and Lipogenic Gene Expression. Organic letters, 2012, vol. 14, no. 20, p. 5358-5361. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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