Botanical species · safety record

Rauvolfia tetraphylla

The EFSA Compendium of Botanicals holds 36 constituent measurements and 3 adverse-effect records for Rauvolfia tetraphylla. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Rauvolfia tetraphylla L.

36Constituent measurements

3Safety records

15Cited sources

0Licensed products (Canada)

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Ajmalicine	Roots and other underground parts	Solvent extraction	≥ 0.14 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Ajmalicine	Roots and other underground parts	Solvent extraction	≤ 0.15 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Ajmalicine	Leaves	Solvent extraction	0.36 Milligram/gram	UHPLC-MS-MS	Resolve DOI
Ajmalicine	Roots and other underground parts	Solvent extraction	120.51 Milligram/gram	UHPLC-MS-MS	Resolve DOI
Alpha-yohimbine	Leaves	Solvent extraction	≥ 0.05 Percent	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	Resolve DOI
Alpha-yohimbine	Leaves	Solvent extraction	≤ 0.21 Percent	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	Resolve DOI
Indole alkaloids	Leaves	Solvent extraction	≥ 0.029 Percent	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	Resolve DOI
Indole alkaloids	Leaves	Solvent extraction	≤ 0.19 Percent	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	Resolve DOI
Indole alkaloids	Leaves	Solvent extraction	—	HPLC-DAD	Resolve DOI
Indole alkaloids	Leaves	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Indole alkaloids	Stem / stalk	—	—	Nuclear Magnetic Resonance (NMR) and Electron Spin Resonance (ESR) spectroscopy	Resolve DOI
Indole alkaloids	Aerial part of plants	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Indole alkaloids	Roots and other underground parts	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Indole alkaloids	Leaves	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Indole alkaloids	Roots and other underground parts	Solvent extraction	1.51 Milligram/gram	UHPLC-MS-MS	Resolve DOI
Indole alkaloids	Leaves	Solvent extraction	15.79 Milligram/gram	UHPLC-MS-MS	Resolve DOI
Indole alkaloids	Leaves	Solvent extraction	25.19 Milligram/gram	UHPLC-MS-MS	Resolve DOI
Indole alkaloids	Roots and other underground parts	Solvent extraction	5.07 Milligram/gram	UHPLC-MS-MS	Resolve DOI
Isoreserpiline	Leaves	Solvent extraction	≥ 0.032 Percent	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	Resolve DOI
Isoreserpiline	Leaves	Solvent extraction	≤ 0.14 Percent	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	Resolve DOI
Labdane diterpenes	Stem / stalk	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Reserpine	Leaves	Solvent extraction	≥ 0.058 Percent	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	Resolve DOI
Reserpine	Leaves	Solvent extraction	≤ 0.12 Percent	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	Resolve DOI
Reserpine	Roots and other underground parts	Solvent extraction	≥ 0.15 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Reserpine	Roots and other underground parts	Solvent extraction	≤ 0.16 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Reserpine	Roots and other underground parts	Solvent extraction	14.45 Milligram/gram	UHPLC-MS-MS	Resolve DOI
Reserpine	Leaves	Solvent extraction	18.16 Milligram/gram	UHPLC-MS-MS	Resolve DOI
Yohimbine	Roots and other underground parts	Solvent extraction	100.21 Milligram/gram	UHPLC-MS-MS	Resolve DOI
Yohimbine	Leaves	Solvent extraction	8.42 Milligram/gram	UHPLC-MS-MS	Resolve DOI
Alkaloids	Roots and other underground parts	Solvent extraction	6.64 Percent	HPLC-MS/MS	No resolvable identifier
Indole alkaloids	Aerial part of plants	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Reserpine	Leaves	Solvent extraction	0.016 Percent	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	No resolvable identifier
Reserpine	Stem / stalk	Solvent extraction	0.102 Percent	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	No resolvable identifier
Reserpine	Roots and other underground parts	Solvent extraction	0.205 Percent	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	No resolvable identifier
Reserpine	Roots and other underground parts	Solvent extraction	450.7 Microgram/gram	HPLC-MS/MS	No resolvable identifier
Yohimbine	Leaves	Solvent extraction	6.11 Percent	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Digestive	Digestive	Leaves	Solvent extraction	Rat (as animal)	Short-term toxicity	No resolvable identifier
Other toxicities	—	Leaves	Solvent extraction	Rat (as animal)	Acute toxicity	No resolvable identifier
Other toxicities	—	Leaves	Solvent extraction	Rat (as animal)	Short-term toxicity	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Tamboli, S.R., Pandit, R.S. Acute toxicity evaluation of Rauvolfia tetraphylla leaf extract in rat by up and down method. International journal of pharmaceutical and clinical research, 2014, vol. 6, no. 4, p. 316-319.
Tamboli, S.R., Pandit, R.S. Subacute toxicity evaluation of Rauvolfia tetraphylla methanolic leaf extract in Sprague dawley rat. International journal of pharmaceutical sciences review and research, 2015, vol. 34, no. 1, p. 152-157.
Panda, Sangram K., Pattanayak, Priyabrata., Oraon, Awadhesh., Parhi, Pravat K. Quantitative estimation of reserpine in different parts of R. serpentina and R. tetraphylla by using HPTLC. Pharmacia lettre, 2010, vol. 2, no. 5, p. 363-370.
Gupta, Shikha., Shanker, Karuna., Srivastava, Santosh K. HPTLC method for the simultaneous determination of four indole alkaloids in Rauwolfia tetraphylla: A study of organic/green solvent and continuous/pulse sonication . Journal of pharmaceutical and biomedical analysis, 2012, vol. 66, p. 33-39. DOI
Kumar, Arvind., Bhardwaj, M. K., Upadhyay, A. K., Tiwari, Anupa., Ohdar, Bikram Deo. Quantitative determination of yohimbine alkaloid in the different part of the Rauvolfia tetraphylla. Journal of chemical and pharmaceutical research, 2011, vol. 3, no. 2, p. 907-910.
Gupta, Shikha., Khanna, Vinay Kumar., Maurya, Anupam., Bawankule, Dnyaneshwar Umrao., Shukla, Rajendra Kumar., Pal, Anirban., Srivastava, Santosh Kumar. Bioactivity guided isolation of antipsychotic constituents from the leaves of Rauwolfia tetraphylla L. . Fitoterapia, 2012, vol. 83, no. 6, p. 1092-1099. DOI
Bindu, S., Rameshkumar, K. B., Kumar, Brijesh., Singh, Awantika., Anilkumar, C. Distribution of reserpine in Rauvolfia species from India - HPTLC and LC-MS studies. Industrial crops and products, 2014, vol. 62, p. 430-436.
Verma, Ram Kishore., Gupta, Shikha., Gupta, Madan Mohan., Srivastava, Santosh Kumar. A SIMPLE ISOCRATIC HPLC METHOD FOR THE SIMULTANEOUS DETERMINATION OF ANTIPSYCHOTIC INDOLE ALKALOIDS IN RAUWOLFIA TETRAPHYLLA . Journal of liquid chromatography & related technologies, 2012, vol. 35, no. 7, p. 937-950. DOI
Pandey, Devendra Kumar., Radha., Dey, Abhijit. A validated and densitometric HPTLC method for the simultaneous quantification of reserpine and ajmalicine in Rauvolfia serpentina and Rauvolfia tetraphylla . Revista brasileira de farmacognosia-brazilian journal of pharmacognosy, 2016, vol. 26, no. 5, p. 553-557. DOI
MARTINEZ, JA., VELEZ, H., SANTANA, T. AN ALKALOID FROM 2 RAUWOLFIA SPP. Phytochemistry, 1989, vol. 28, no. 3, p. 961-962. DOI
Gao, Yuan., Zhou, Dong-Sheng., Kong, Ling-Mei., Hai, Ping., Li, Yan., Wang, Fei., Liu, Ji-Kai. Rauvotetraphyllines A-E, new indole alkaloids from Rauvolfia tetraphylla. Natural products and bioprospecting, 2012, vol. 2, no. 2, p. 65-69.
Gao, Yuan., Zhou, Dong-Sheng., Hai, Ping., Li, Yan., Wang, Fei. Hybrid Monoterpenoid Indole Alkaloids Obtained as Artifacts from Rauvolfia tetraphylla . Natural products and bioprospecting, 2015, vol. 5, no. 5, p. 247-253. DOI
Arambewela, LSR., Madawela, G. Alkaloids from Rauvolfia canescens. Pharmaceutical biology, 2001, vol. 39, no. 3, p. 239-240. DOI
Brahmachari, Goutam., Mandal, Lalan Ch., Gorai, Dilip., Mondal, Avijit., Sarkar, Sajal., Majhi, Sasadhar. A new labdane diterpene from Rauvolfia tetraphylla Linn. (Apocynaceae). Journal of chemical research, 2011, no. 12, p. 678-680. DOI
Kumar, Sunil., Singh, Awantika., Bajpai, Vikas., Srivastava, Mukesh., Singh, Bhim Pratap., Ojha, Sanjeev., Kumar, Brijesh. Simultaneous Determination of Bioactive Monoterpene Indole Alkaloids in Ethanolic Extract of Seven Rauvolfia Species using UHPLC with Hybrid Triple Quadrupole Linear Ion Trap Mass Spectrometry . Phytochemical analysis, 2016, vol. 27, no. 5, p. 296-303. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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