Botanical species · safety record

Rauvolfia vomitoria

The EFSA Compendium of Botanicals holds 31 constituent measurements and 4 adverse-effect records for Rauvolfia vomitoria. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Rauvolfia vomitoria Afzel.

31Constituent measurements

4Safety records

12Cited sources

0Licensed products (Canada)

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Ajmalicine	Roots and other underground parts	Solvent extraction	2.12 Milligram/gram	UHPLC-MS-MS	Resolve DOI
Ajmalicine	Leaves	Solvent extraction	6.84 Milligram/gram	UHPLC-MS-MS	Resolve DOI
Ajmaline	Leaves	Solvent extraction	2.32 Milligram/gram	UHPLC-MS-MS	Resolve DOI
Ajmaline	Roots and other underground parts	Solvent extraction	48.43 Milligram/gram	UHPLC-MS-MS	Resolve DOI
Indole alkaloids	Roots and other underground parts	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Indole alkaloids	Aerial part of plants	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Rescinnamine	Roots and other underground parts	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Reserpine	Roots and other underground parts	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Reserpine	Roots and other underground parts	Solvent extraction	21.14 Milligram/gram	UHPLC-MS-MS	Resolve DOI
Reserpine	Leaves	Solvent extraction	25.23 Milligram/gram	UHPLC-MS-MS	Resolve DOI
Serpentine	Leaves	Solvent extraction	1.05 Milligram/gram	UHPLC-MS-MS	Resolve DOI
Serpentine	Roots and other underground parts	Solvent extraction	87.77 Milligram/gram	UHPLC-MS-MS	Resolve DOI
Yohimbine	Roots and other underground parts	Solvent extraction	11.63 Milligram/gram	UHPLC-MS-MS	Resolve DOI
Yohimbine	Leaves	Solvent extraction	24.24 Milligram/gram	UHPLC-MS-MS	Resolve DOI
Ajmalicine	Roots and other underground parts	—	—	Mass Spectroscopy and hyphenated methods without chromatography	No resolvable identifier
Alkaloids	Roots and other underground parts	Solvent extraction	6.05 Percent	HPLC with standard detection methods	No resolvable identifier
Alpha-yohimbine	Roots and other underground parts	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Alstonine	Roots and other underground parts	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Harman	Roots and other underground parts	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Indole alkaloids	Roots and other underground parts	Solvent extraction	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	No resolvable identifier
Indole alkaloids	Leaves	—	—	Mass Spectroscopy and hyphenated methods without chromatography	No resolvable identifier
Indole alkaloids	Roots and other underground parts	—	—	Mass Spectroscopy and hyphenated methods without chromatography	No resolvable identifier
Indole alkaloids	Roots and other underground parts	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Oxalates	Seed	Drying (dehydration)	5.81 Milligram/100 gram	Colorimetry, Spectroscopy (Spectrometry) and Photometry	No resolvable identifier
Phytic acid	Seed	Drying (dehydration)	351 Milligram/100 gram	Colorimetry, Spectroscopy (Spectrometry) and Photometry	No resolvable identifier
Reserpiline	Leaves	—	—	Mass Spectroscopy and hyphenated methods without chromatography	No resolvable identifier
Reserpine	Roots and other underground parts	Solvent extraction	689.5 Microgram/gram	HPLC with standard detection methods	No resolvable identifier
Reserpine	Roots and other underground parts	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Yohimbine	Leaves	—	—	Mass Spectroscopy and hyphenated methods without chromatography	No resolvable identifier
Yohimbine	Roots and other underground parts	—	—	Mass Spectroscopy and hyphenated methods without chromatography	No resolvable identifier
Yohimbine	Roots and other underground parts	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Digestive	Liver	Roots and other underground parts	Solvent extraction	Rat (as animal)	Short-term toxicity	Resolve DOI
Neurotoxicity	Brain	Roots and other underground parts	Solvent extraction	Rat (as animal)	Short-term toxicity	Resolve DOI
Hepatotoxicity	Urogenital: kidneys	Live plants	Solvent extraction	Rat (as animal)	Short-term toxicity	No resolvable identifier
Reproductive	Urogenital: ovaries	Roots and other underground parts	Solvent extraction	Rat (as animal)	Short-term toxicity	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Akanji, M.A., Yakubu, M.T., Kazeem, M.I. Hypolipidemic and toxicological potential of aqueous extract of Rauvolfia vomitoria afzel root in wistar rats. Journal of medical sciences (faisalabad), 2013, vol. 13, no. 4, p. 253-260. DOI
Aquiasia, N. A., Oyebadejo, S. A., Bassey, I. E., Ufot, A. L., Akpan, F. I. Effect of the ethanolic root extract of Rauwolfia vomitaria on the histology of the ovaries of female albino wistar rats. Cibtech journal of pharmaceutical sciences, 2014, vol. 3, no. 3, p. 1-9.
Ekong, Moses B., Peter, Aniekan I., Edagha, Innocent A., Ekpene, Ubong U., Friday, Daniel A. Rauwolfia vomitoria inhibits olfaction and modifies olfactory bulb cells. Brain research bulletin, 2016, vol. 124, p. 206-213. DOI
Eteng, M.U., Ibekwe, H.A., Abolaji, A.O., Okoi, A.I., Onwuka, F.C., Osuchukwu, N.C. Effect of Rauwolfia vomitoria Afzel (Apocynaceae) extract on serum amino transferase and alkaline phosphatase activities and selected indices of liver and kidney functions. African journal of biotechnology, 2009, vol. 8, no. 18, p. 4604-4607.
Lovati, M., Peterlongo, F., Ruffilli, T., Zini, G. F. Two new indole alkaloids from Rauwolfia vomitoria. Fitoterapia, 1996, vol. 67, no. 5, p. 422-426.
Balogun, Adebisi M., Fetuga, Babatunde L. Tannin, phytin and oxalate contents of some wild underutilized crop-seeds in Nigeria. Food chemistry, 1988, vol. 30, no. 1, p. 37-43.
Bindu, S., Rameshkumar, K. B., Kumar, Brijesh., Singh, Awantika., Anilkumar, C. Distribution of reserpine in Rauvolfia species from India - HPTLC and LC-MS studies. Industrial crops and products, 2014, vol. 62, p. 430-436.
DUEZ, P., CHAMART, S., VANHAELEN, M., VANHAELENFASTRE, R., HANOCQ, M., MOLLE, L. COMPARISON BETWEEN HIGH-PERFORMANCE THIN-LAYER CHROMATOGRAPHY-DENSITOMETRY AND HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY FOR THE DETERMINATION OF AJMALINE, RESERPINE AND RESCINNAMINE IN RAUWOLFIA-VOMITORIA ROOT BARK . Journal of chromatography, 1986, vol. 356, no. 2, p. 334-340. DOI
Kumar, Sunil., Bajpai, Vikas., Singh, Awantika., Bindu, S., Srivastava, Mukesh., Rameshkumar, K. B., Kumar, Brijesh. Rapid fingerprinting of Rauwolfia species using direct analysis in real time mass spectrometry combined with principal component analysis for their discrimination. Analytical methods, 2015, vol. 7, no. 14, p. 6021-6026.
Zeng, Jun., Zhang, Dong-Bo., Zhou, Pan-Pan., Zhang, Qi-Li., Zhao, Lei., Chen, Jian-Jun., Gao, Kun. Rauvomines A and B, Two Monoterpenoid Indole Alkaloids from Rauvolfia vomitoria . Organic letters, 2017, vol. 19, no. 15, p. 3998-4001. DOI
Li, Lin., He, Hong-ping., Zhou, Hua., Hao, Xiao-jiang. Indole alkaloids from Rauwolfia vomitoria. Tianran chanwu yanjiu yu kaifa, 2007, vol. 19, no. 2, p. 235-239.
Kumar, Sunil., Singh, Awantika., Bajpai, Vikas., Srivastava, Mukesh., Singh, Bhim Pratap., Ojha, Sanjeev., Kumar, Brijesh. Simultaneous Determination of Bioactive Monoterpene Indole Alkaloids in Ethanolic Extract of Seven Rauvolfia Species using UHPLC with Hybrid Triple Quadrupole Linear Ion Trap Mass Spectrometry . Phytochemical analysis, 2016, vol. 27, no. 5, p. 296-303. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

Continue

Independent literature