Botanical species · safety record

Reynoutria multiflora

The EFSA Compendium of Botanicals holds 16 constituent measurements, 3 adverse-effect records and 1 genotoxicity assay for Reynoutria multiflora. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Reynoutria multiflora (Thunb.) Moldenke

16Constituent measurements

4Safety records

8Cited sources

453Licensed products (Canada)

Also recorded as

Fallopia multiflora (Thunb.) Haraldson
Polygonum multiflorum Thunb.

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 453 licensed products naming Reynoutria multiflora as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Dry
Extract Type TBA

Source material stated

Aged bark
Dried lianoid stem
Dried root tuber
Herb
Herb top extract
New material
Prepared Root-stewed in black beans
Radix

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Aloe-emodin	Roots and other underground parts used as staple food	Solvent extraction	64.22 Microgram/gram	Gaschromatography (GC)	Resolve DOI
Anthraquinone	Roots and other underground parts	Solvent extraction	≥ 0.043 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Anthraquinone	Roots and other underground parts	Solvent extraction	≤ 0.341 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Anthraquinone	Roots and other underground parts	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Chrysophanol	Roots and other underground parts used as staple food	Solvent extraction	27.41 Microgram/gram	Gaschromatography (GC)	Resolve DOI
Emodin	Roots and other underground parts used as staple food	Solvent extraction	289.6 Microgram/gram	Gaschromatography (GC)	Resolve DOI
Physcion	Roots and other underground parts	Solvent extraction	≤ 0.197 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Physcion	Roots and other underground parts	Solvent extraction	≥ 0.034 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Physcion	Roots and other underground parts used as staple food	Solvent extraction	202.1 Microgram/gram	Gaschromatography (GC)	Resolve DOI
Rhein	Roots and other underground parts used as staple food	Solvent extraction	288.6 Microgram/gram	Gaschromatography (GC)	Resolve DOI
Stilbenes, stilbene derivatives	Roots and other underground parts	Solvent extraction	—	UHPLC-MS-MS	Resolve DOI
Chrysophanol	Roots and other underground parts	—	—	Element spectroscopy	No resolvable identifier
Indole alkaloids	Roots and other underground parts	—	—	Element spectroscopy	No resolvable identifier
Physcion	Roots and other underground parts	—	—	Element spectroscopy	No resolvable identifier
Sennoside a	Roots and other underground parts	—	—	Element spectroscopy	No resolvable identifier
Sennoside b	Roots and other underground parts	—	—	Element spectroscopy	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Digestive	Digestive	Unspecified	Solvent extraction	—	In vitro	Resolve DOI
Hepatotoxicity	Liver	Roots and other underground parts	Solvent extraction	Human (as organism)	Case report	Resolve DOI
Hepatotoxicity	Liver	Roots and other underground parts	Solvent extraction	Rat (as animal)	Subchronic	Resolve DOI

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	DNA damage and/or repair	single cell gel/comet assay in mammalian cells for detection of DNA damage	House mouse (as animal)	No data	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Jiao, Yue., Zuo, Yuegang. Ultrasonic Extraction and HPLC Determination of Anthraquinones, Aloe-emodine, Emodine, Rheine, Chrysophanol and Physcione, in Roots of Polygoni multiflori . Phytochemical analysis, 2009, vol. 20, no. 4, p. 272-278. DOI
Zuo, Yuegang., Wang, Chengjun., Lin, Yuejuan., Guo, Jinwen., Deng, Yiwei. Simultaneous determination of anthraquinones in radix Polygoni multiflori by capillary gas chromatography coupled with flame ionization and mass spectrometric detection . Journal of chromatography a, 2008, vol. 1200, no. 1, p. 43-48. DOI
Yang, Xiuwei., Gu, Zheming., Ma, Chaomei., Hattori, Masao., Namba, Tsuneo. A new indole derivative isolated from the root of tuber fleece-flower.. Zhongcaoyao, 1998, vol. 29, no. 1, p. 5-11.
Zhang, Qiuhua., Wu, Chunfu., Duan, Lian., Yang, Jingyu. Genotoxic studies on Panax ginseng and Polygonum multiflorum and their combination in mouse peripheral lymphocyte cells.. Asian journal of traditional medicines, 2007, vol. 2, no. 4, p. 127-134.
Meng, Ya-Kun., Li, Chun-Yu., Li, Rui-Yu., He, Lan-Zhi., Cui, He-Rong., Yin, Ping., Zhang, Cong-En., Li, Peng-Yan., Sang, Xiu-Xiu., Wang, Ya., Niu, Ming., Zhang, Ya-Ming., Guo, Yu-Ming., Sun, Rong., Wang, Jia-Bo., Bai, Zhao-Fang., Xiao, Xiao-He. Cis-stilbene glucoside in Polygonum multiflorum induces immunological idiosyncratic hepatotoxicity in LPS-treated rats by suppressing PPAR-gamma. . Acta pharmacologica sinica, 2017. DOI
Ma, Jiang., Zheng, Li., He, Yi-Sheng., Li, Hui-Jun. Hepatotoxic assessment of Polygoni Multiflori Radix extract and toxicokinetic study of stilbene glucoside and anthraquinones in rats . Journal of ethnopharmacology, 2015, vol. 162, p. 61-68. DOI
Yang, Dong., Zhao, Jiadi., Liu, Shu., Song, Fengrui., Liu, Zhiqiang. The screening of potential alpha-glucosidase inhibitors from the Polygonum multiflorum extract using ultrafiltration combined with liquid chromatography-tandem mass spectrometry . Analytical methods, 2014, vol. 6, no. 10, p. 3353-3359. DOI
Calitz, C., Du Plessis, L., Gouws, C., Steyn, D., Steenekamp, J., Muller, C., Hamman, S. Herbal hepatotoxicity: Current status, examples, and challenges. Expert opinion on drug metabolism and toxicology, 2015, vol. 11, no. 10, p. 1551-1565. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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