Botanical species · safety record

Rhamnus cathartica

The EFSA Compendium of Botanicals holds 5 constituent measurements and 1 adverse-effect record for Rhamnus cathartica. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Rhamnus cathartica L.

5Constituent measurements

1Safety records

4Cited sources

18Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 18 licensed products naming Rhamnus cathartica as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Source material stated

Aged bark
Bark
Fruit
Fruit(s)
Stem bark

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Alkaloids	Roots and other underground parts	Solvent extraction	10 Milligram/100 gram	Colorimetry, Spectroscopy (Spectrometry) and Photometry	No resolvable identifier
Anthracene derivatives	Fruit unspecified	Solvent extraction	≤ 0.37 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Anthracene derivatives	Fruit unspecified	Solvent extraction	≥ 0.31 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Anthraquinones	Fruit unspecified	Solvent extraction	14.3 Microgram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Emodin	Fruit unspecified	Solvent extraction	585.6 Microgram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Hepatotoxicity	Liver	Aerial part of plants	Drying (dehydration)	House mouse (as animal)	Subchronic	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Shmygareva, A.A., Kurkin, V.A., Sankov, A.N. Validated high-performance liquid chromatography method for quantitative determination of anthracene derivatives in decoction, syrup and water-alcohol extract of Rhamnus cathartica L. fruits. International journal of pharmacognosy and phytochemical research, 2016, vol. 8, no. 4, p. 683-685.
Lichtensteiger, CA., Johnston, NA., Beasley, VR. Rhamnus cathartica (Buckthorn) hepatocellular toxicity in mice. Toxicologic pathology, 1997, vol. 25, no. 5, p. 449-452.
Hultin, E., Torssell, K. Alkaloid-screening of swedish plants. Phytochemistry, 1965, vol. 4, no. 3, p. 425-433.
Epifano, Francesco., Genovese, Salvatore., Kremer, Dario., Randic, Marco., Carlucci, Giuseppe., Locatelli, Marcello. Re-investigation of the Anthraquinone Pool of Rhamnus spp.: Madagascin from the Fruits of Rhamnus cathartica and R. intermedia . Natural product communications, 2012, vol. 7, no. 8, p. 1029-1032.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature