Botanical species · safety record

Rheum australe

The EFSA Compendium of Botanicals holds 15 constituent measurements and 1 adverse-effect record for Rheum australe. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Rheum australe D. Don

15Constituent measurements

1Safety records

6Cited sources

1Licensed products (Canada)

Also recorded as

Rheum emodi Wall. ex Meisn.

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 1 licensed products naming Rheum australe as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Source material stated

Root

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
1,8-dihydroxyanthraquinone derivatives	Roots and other underground parts	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Aloe-emodin	Roots and other underground parts	Solvent extraction	0.025 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Aloe-emodin	Roots and other underground parts	Solvent extraction	0.095 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Anthraquinones	Roots and other underground parts	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Chrysophanol	Roots and other underground parts	Solvent extraction	10.63 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Chrysophanol	Roots and other underground parts	Solvent extraction	1.32 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Emodin	Roots and other underground parts	Solvent extraction	3.25 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Emodin	Roots and other underground parts	Solvent extraction	1.07 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Physcion	Roots and other underground parts	Solvent extraction	2.91 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
1,8-dihydroxyanthraquinone derivatives	Roots and other underground parts	Solvent extraction	—	Unspecified	No resolvable identifier
Cardiac glycosides	Roots and other underground parts	Solvent extraction	—	Phytochemical screening	No resolvable identifier
Furan derivatives	Roots and other underground parts	—	—	Unspecified	No resolvable identifier
Gallic acid	Roots and other underground parts	Solvent extraction	90.9 Microgram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
P-coumaric acid	Roots and other underground parts	Solvent extraction	112 Microgram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Phlobotannins	Roots and other underground parts	Solvent extraction	—	Phytochemical screening	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Digestive	Digestive	Roots and other underground parts	Solvent extraction	—	In vitro	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Rokaya, Maan Bahadur., Marsik, Petr., Muenzbergova, Zuzana. Active constituents in Rheum acuminatum and Rheum australe (Polygonaceae) roots: A variation between cultivated and naturally growing plants. BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 2012, vol. 41, p. 83-90. DOI
Singh, P., Nee Pant, G.J., Rawat, M.S.M. Phytochemistry and biological activity perspectives of rheum species. Natural Products Journal, 2016, vol. 6, no. 2, p. 84-93.
Kumar, Devanga Ragupathi Naveen., George, Vazhapilly Cijo., Suresh, Palamadai Krishnan., Kumar, Rangasamy Ashok. Cancer-specific chemoprevention and anti-metastatic potentials of Rheum emodi rhizome ethyl acetate extracts and identification of active principles through HPLC and GC-MS analysis. PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2015, vol. 28, no. 1, p. 83-93.
Jahan, Nazish., Khalil-Ur-Rahman., Ali, Shoukat., Asi, M. Rafiq. PHENOLIC ACID AND FLAVONOL CONTENTS OF GEMMO-MODIFIED AND NATIVE EXTRACTS OF SOME INDIGENOUS MEDICINAL PLANTS. PAKISTAN JOURNAL OF BOTANY, 2013, vol. 45, no. 5, p. 1515-1519.
Ye, Ben-Gui., Feng, Yong., Wang, Shu. Scientific evaluation of the acute toxicity and 13-week subchronic toxicity of Rheum emodi rhizome extracts in Sprague Dawley rats. FOOD AND CHEMICAL TOXICOLOGY, 2014, vol. 66, p. 278-285. DOI
Arvindekar, Aditya., More, Tanaji., Payghan, Pavan V., Laddha, Kirti., Ghoshal, Nanda., Arvindekar, Akalpita. Evaluation of anti-diabetic and alpha glucosidase inhibitory action of anthraquinones from Rheum emodi. FOOD & FUNCTION, 2015, vol. 6, no. 8, p. 2693-2700. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature