Botanical species · safety record

Rheum officinale

The EFSA Compendium of Botanicals holds 34 constituent measurements and 1 genotoxicity assay for Rheum officinale. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Rheum officinale Baill.

34Constituent measurements

1Safety records

9Cited sources

602Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 602 licensed products naming Rheum officinale as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Dry
Extract Type TBA
solid

Source material stated

Leaf
Racine
Radix
Rheum officinale - root
Rheum officinale - root and rhizome
Rheum palmatum - Root and rhizome
Rheum tanguticum - Root and rhizome
Rhizome

What the records describe

Constituents measured

Plant parts

Preparations

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Aloe-emodin	Roots and other underground parts	Solvent extraction	0.65 Milligram/gram	Chromatographic tests	Resolve DOI
Aloe-emodin	Unspecified	Solvent extraction	5.56 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Aloe-emodin	Roots and other underground parts	Solvent extraction	≥ 0.05 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Aloe-emodin	Roots and other underground parts	Solvent extraction	≤ 0.33 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Anthraquinone	Unspecified	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Anthraquinone	Unspecified	Solvent extraction	34.59 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Anthraquinone	Roots and other underground parts	Solvent extraction	≤ 2.08 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Anthraquinone	Roots and other underground parts	Solvent extraction	≥ 0.32 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Anthraquinone	Roots and other underground parts	Solvent extraction	21 Gram/kilogram	Chromatographic tests	Resolve DOI
Anthraquinones	Roots and other underground parts	Solvent extraction	—	UHPLC-MS-MS	Resolve DOI
Anthraquinones	Roots and other underground parts	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Chrysophanol	Unspecified	Solvent extraction	0.21 Milligram/gram	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Chrysophanol	Unspecified	Solvent extraction	12.81 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Chrysophanol	Roots and other underground parts	Solvent extraction	≤ 0.34 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Chrysophanol	Roots and other underground parts	Solvent extraction	≥ 0.08 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Chrysophanol	Roots and other underground parts	Solvent extraction	0.77 Milligram/gram	Chromatographic tests	Resolve DOI
Emodin	Roots and other underground parts	Solvent extraction	0.35 Milligram/gram	Chromatographic tests	Resolve DOI
Emodin	Roots and other underground parts	Solvent extraction	≥ 0.05 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Emodin	Roots and other underground parts	Solvent extraction	≤ 0.19 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Emodin	Unspecified	Solvent extraction	5.52 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Emodin	Unspecified	Solvent extraction	0.34 Milligram/gram	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Physcion	Roots and other underground parts	Solvent extraction	≤ 0.07 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Physcion	Unspecified	Solvent extraction	3.07 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Physcion	Roots and other underground parts	Solvent extraction	0.14 Milligram/gram	Chromatographic tests	Resolve DOI
Physcion	Roots and other underground parts	Solvent extraction	≥ 0.02 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Rhein	Roots and other underground parts	Solvent extraction	≥ 0.09 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Rhein	Unspecified	Solvent extraction	0.18 Milligram/gram	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Rhein	Unspecified	Solvent extraction	7.63 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Rhein	Roots and other underground parts	Solvent extraction	2.36 Milligram/gram	Chromatographic tests	Resolve DOI
Rhein	Roots and other underground parts	Solvent extraction	≤ 1.26 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Sennoside a	Roots and other underground parts	Solvent extraction	—	UHPLC-MS-MS	Resolve DOI
Sennoside a	Roots and other underground parts	Solvent extraction	13.68 Milligram/gram	Chromatographic tests	Resolve DOI
Sennoside b	Roots and other underground parts	Solvent extraction	5.87 Milligram/gram	Chromatographic tests	Resolve DOI
Stilbenes, stilbene derivatives	Roots and other underground parts used as staple food	Solvent extraction	—	Chromatographic tests	Resolve DOI

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	—	other	Salmonella typhimurium (as organism)	No data	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Aichner, Dorothea., Ganzera, Markus. Analysis of anthraquinones in rhubarb (Rheum palmatum and Rheum officinale) by supercritical fluid chromatography . Talanta, 2015, vol. 144, p. 1239-1244. DOI
Mahmoud, I., Alkofahi, A., Abdelaziz, A. Mutagenic and toxic activities of several spices and some jordanian medicinal plants. Pharmaceutical biology, 1992, vol. 30, no. 2, p. 81-85. DOI
Ngoc, Tran Minh., Minh, Pham Thi Hong., Hung, Tran Manh., Thuong, Phuong Thien., Lee, IkSoo., Min, Byung-Sun., Bae, KiHwan. Lipoxygenase inhibitory constituents from rhubarb. Archives of pharmacal research, 2008, vol. 31, no. 5, p. 598-605. DOI
Sun, SW., Yeh, PC. Analysis of rhubarb anthraquinones and bianthrones by microemulsion electrokinetic chromatography . Journal of pharmaceutical and biomedical analysis, 2005, vol. 36, no. 5, p. 995-1001. DOI
Ye, Min., Han, Jian., Chen, Hubiao., Zheng, Junhua., Guo, Dean. Analysis of phenolic compounds in rhubarbs using liquid chromatography coupled with electrospray ionization mass spectrometry . Journal of the american society for mass spectrometry, 2007, vol. 18, no. 1, p. 82-91. DOI
Wang, Jiabo., Li, Huifang., Jin, Cheng., Qu, Yi., Xiao, Xiaohe. Development and validation of a UPLC method for quality control of rhubarb-based medicine: Fast simultaneous determination of five anthraquinone derivatives . Journal of pharmaceutical and biomedical analysis, 2008, vol. 47, no. 4-5, p. 765-770. DOI
Sun, MZ., Sakakibara, H., Ashida, H., Danno, G., Kanazawa, K. Cytochrome P4501A1-inhibitory action of antimutagenic anthraquinones in medicinal plants and the structure-activity relationship . Bioscience biotechnology and biochemistry, 2000, vol. 64, no. 7, p. 1373-1378. DOI
Huang, Yanyan., Sun, Ailing., Qi, Yuanying., Liu, Renmin. Purification of hydroxyanthraquinones and cinnamic acid from the roots of Rheum officinale Baill . Journal of separation science, 2008, vol. 31, no. 2, p. 283-287. DOI
Yang, FQ., Zhang, TY., Xu, GQ., Chou, FE., Ito, Y. pH-modulated stepwise elution CCC and its application to the preparative separation of hydroxyanthraquinone compounds from traditional Chinese medicinal herbs . Journal of liquid chromatography & related technologies, 2001, vol. 24, no. 11-12, p. 1617-1628. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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