Botanical species · safety record

Rheum rhaponticum

The EFSA Compendium of Botanicals holds 11 constituent measurements, 1 adverse-effect record and 1 genotoxicity assay for Rheum rhaponticum. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Rheum rhaponticum L.

11Constituent measurements

2Safety records

5Cited sources

11Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 11 licensed products naming Rheum rhaponticum as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Source material stated

Rheum rhaponticum - root
Root

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Aloe-emodin	Roots and other underground parts	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Aloin a	Roots and other underground parts	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Aloin b	Roots and other underground parts	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Chrysophanol	Roots and other underground parts	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Deoxyrhaponticin	Roots and other underground parts	Solvent extraction	11.5 Milligram/gram	UV/VIS spectroscopy (photometry)	Resolve DOI
Deoxyrhaponticin	Stem / stalk	Solvent extraction	—	UV/VIS spectroscopy (photometry)	Resolve DOI
Rhaponticin	Roots and other underground parts	Solvent extraction	25.5 Milligram/gram	UV/VIS spectroscopy (photometry)	Resolve DOI
Rhaponticin	Stem / stalk	Solvent extraction	0.3 Milligram/gram	UV/VIS spectroscopy (photometry)	Resolve DOI
Anthraquinones	Roots and other underground parts	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Oxalic acid	Stem / stalk	Solvent extraction	—	Unspecified	No resolvable identifier
Stilbenes, stilbene derivatives	Roots and other underground parts	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Systemic	Digestive	Stem / stalk	—	Human (as organism)	Case report	No resolvable identifier

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	gene mutation	bacterial reverse mutation assay	Salmonella typhimurium (as organism)	With	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Varslot, O. Rhubarb poisoning. Causal connection: Oxalic acid or anthraquinone derivatives?. Tidsskrift for den norske laegeforening, 1980, vol. 100, no. 14, p. 959-961+977.
Paneitz, Andrea., Westendorf, Johannes. Anthranoid contents of rhubarb (Rheum undulatum L.) and other Rheum species and their toxicological relevance. European food research and technology, 1999, p. 97-101.
Smolarz, Helena Danuta., Swatko-Ossor, Marta., Ginalska, Grazyna., Medynska, Ewa. Antimycobacterial Effect of Extract and Its Components from Rheum rhaponticum. JOURNAL OF AOAC INTERNATIONAL, 2013, vol. 96, no. 1, p. 155-160. DOI
Smolarz, H. D., Halka, A., Chabros, O., Dzido, T. H. Rapid Method for Rhaponticin and Deoxyrhaponticin Separation and Determination by TLC in Rheum rhaponticum L. and Rheum undulatum L.. ACTA CHROMATOGRAPHICA, 2013, vol. 25, no. 1, p. 127-134. DOI
Han, Yashan., Cai, Tongyi., Zhou, Santao. Studies on the biochemical composition and use of edible rhubarb. Zhongguo nongye kexue (beijing, china), 1985, p. 92-96.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature