Botanical species · safety record

Rosmarinus officinalis

The EFSA Compendium of Botanicals holds 16 constituent measurements, 5 adverse-effect records and 5 genotoxicity assays for Rosmarinus officinalis. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Rosmarinus officinalis L.

16Constituent measurements

10Safety records

7Cited sources

1,031Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 1,031 licensed products naming Rosmarinus officinalis as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Dry
Extract Type TBA
Fresh

Source material stated

Aerial parts
Branch Leafy
Buds
Chlorella vulgaris - Broken Cell
Dried leaf
Entire dried plant
Flower
Flower tops

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
1,8-cineole	Unspecified	Essential oil	52.2 Percent	GC-MS	Resolve DOI
1,8-cineole	Aerial part of plants	Essential oil	22.01 Percent	GC-MS	Resolve DOI
Camphor	Aerial part of plants	Essential oil	7.57 Percent	GC-MS	Resolve DOI
Camphor	Unspecified	Essential oil	10.08 Percent	GC-MS	Resolve DOI
Carnosic acid	Unspecified	Super-critical gas extraction	16.9 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Diterpenes	Leaves	Super-critical gas extraction	≤ 2.7 Percent Area	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Diterpenes	Leaves	Super-critical gas extraction	≥ 0.6 Percent Area	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Diterpenes	Leaves	Super-critical gas extraction	≤ 3.9 Percent Area	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Diterpenes	Leaves	Super-critical gas extraction	≥ 2.7 Percent Area	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Diterpenes	Leaves	Super-critical gas extraction	≤ 6.3 Percent Area	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Diterpenes	Leaves	Super-critical gas extraction	≥ 5.2 Percent Area	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Diterpenes	Unspecified	Super-critical gas extraction	1.93 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
L-piperitone	Unspecified	Essential oil	6.68 Percent	GC-MS	Resolve DOI
Myrcene	Unspecified	Essential oil	2.61 Percent	GC-MS	Resolve DOI
Myrcene	Aerial part of plants	Essential oil	1.63 Percent	GC-MS	Resolve DOI
Verbenone	Leaves	Essential oil	23.55 Percent	GC-MS	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Digestive	Digestive	Unspecified	—	—	Not reported	No resolvable identifier
Hepatotoxicity	Liver	Unspecified	—	—	Not reported	No resolvable identifier
Nephrotoxicity	Urogenital: kidneys	Unspecified	—	—	Not reported	No resolvable identifier
Neurotoxicity	Brain	Unspecified	—	—	Not reported	No resolvable identifier
Not reported	—	Unspecified	—	Human (as organism)	Case report	No resolvable identifier

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	gene mutation	Mammalian erythrocyte micronucleus test	Rat (as animal)	—	Resolve DOI
Positive	gene mutation	Mammalian erythrocyte micronucleus test	House mouse (as animal)	—	Resolve DOI
Positive	DNA damage and/or repair	single cell gel/comet assay in mammalian cells for detection of DNA damage	House mouse (as animal)	—	Resolve DOI
Positive	chromosome aberration	in vitro gene mutation assay in fungi	Human (as organism)	With and without	Resolve DOI
Positive	chromosome aberration	chromosome aberration assay	Rat (as animal)	—	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Maistro, E. L., Mota, S. F., Lima, E. B., Bernardes, B. M., Goulart, F. C. Genotoxicity and mutagenicity of Rosmarinus officinalis (Labiatae) essential oil in mammalian cells in vivo. Genetics and molecular research, 2010, vol. 9, no. 4, p. 2113-2122. DOI
Contini, Adele., Di Bello, Domenica., Azzara, Alessia., Giovanelli, Silvia., D'Urso, Giuseppina., Piaggi, Simona., Pinto, Barbara., Pistelli, Luisa., Scarpato, Roberto., Testi, Serena. Assessing the cytotoxic/genotoxic activity and estrogenic/antiestrogenic potential of essential oils from seven aromatic plants. Food and chemical toxicology, 2020, vol. 138. DOI
Loutfia, Toilabiya., Hinde, Hami., Abdelmajid, Soulaymani., Naima, Rhalem., Laheen, Ouammi., Doha, Benali., Adbelrhani, Mokhtari., Rachida, Soulaymani-Bencheikh. Poisoning by plants in the Taza-Al Hoceima-Taounate region in Morocco. Pakistan journal of scientific and industrial research, series b: biological sciences, 2013, vol. 56, no. 1, p. 23-28.
Dimitrijevic, Suzana I., Mihajlovski, Katarina R., Antonovic, Dusan G., Milanovic-Stevanovic, Mirjana R., Mijin, Dusan Z. A study of the synergistic antilisterial effects of a sub-lethal dose of lactic acid and essential oils from Thymus vulgaris L., Rosmarinus officinalis L. and Origanum vulgare L.. Food chemistry, 2007, vol. 104, no. 2, p. 774-782. DOI
Gudek, Melek., Cetin, Huseyin. Fumigant Toxicity on Adults of Callosobruchus maculatus (F.) (Coleoptera: Chrysomelidae) of Essential Oil from Rosmarinus officinalis L. and its Side Effects on Chickpea Grains. Journal of essential oil bearing plants, 2017, vol. 20, no. 1, p. 272-281.
Anadon, Arturo., Martinez-Larranaga, Maria R., Martinez, Maria A., Ares, Irma., Garcia-Risco, Monica R., Senorans, Francisco J., Reglero, Guillermo. Acute oral safety study of rosemary extracts in rats. Journal of food protection, 2008, vol. 71, no. 4, p. 790-795. DOI
Anadon, Arturo., Martinez, Maria A., Ares, Irma., Castellano, Victor., Martinez-Larranaga, Maria R., Corzo, Nieves., Olano, Agustin., Montilla, Antonia., Recio, Isidra., Martinez-Maqueda, Daniel., Miralles, Beatriz., Fornari, Tiziana., Garcia-Risco, Monica R., Gonzalez, Monserrat., Reglero, Guillermo. Acute and Repeated Dose (28 Days) Oral Safety Studies of ALIBIRD in Rats. Journal of food protection, 2013, vol. 76, no. 7, p. 1226-1239. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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