Botanical species · safety record

Rubia cordifolia

The EFSA Compendium of Botanicals holds 15 constituent measurements and 3 adverse-effect records for Rubia cordifolia. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Rubia cordifolia L.

15Constituent measurements

3Safety records

6Cited sources

78Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 78 licensed products naming Rubia cordifolia as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Dry
Extract Type TBA

Source material stated

Rhizome
Rhizome and root(s)
Root
Root and Rhizome
Root and rhizome
Root extract
Stem
Stem(s)

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Eugenol	Roots and other underground parts	Essential oil	12.7 Percent	GC-MS	Resolve DOI
Menthol	Roots and other underground parts	Essential oil	2.7 Percent	GC-MS	Resolve DOI
Methyleugenol	Roots and other underground parts	Essential oil	1.2 Percent	GC-MS	Resolve DOI
Myristicin	Roots and other underground parts	Essential oil	1 Percent	GC-MS	Resolve DOI
Alkaloids	Roots and other underground parts	Solvent extraction	0.65 Microgram/gram	Unspecified	No resolvable identifier
Anthraquinones	Stem / stalk	Solvent extraction	4.02 Percent	Phytochemical screening	No resolvable identifier
Cardiac glycosides	Stem / stalk	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Cardiac glycosides	Roots and other underground parts	Solvent extraction	—	Unspecified	No resolvable identifier
Juglone	Roots and other underground parts	Solvent extraction	—	Unspecified	No resolvable identifier
Lucidin	—	—	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Phenolic compounds	Roots and other underground parts	Solvent extraction	0.17 Microgram/gram	Unspecified	No resolvable identifier
Phenolic compounds	Stem / stalk	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Sterols, total	Stem / stalk	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Tannins	Stem / stalk	Solvent extraction	20 Percent	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Tannins	Roots and other underground parts	Solvent extraction	0.52 Microgram/gram	Unspecified	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Digestive	Liver	Fruit unspecified	Solvent extraction	House mouse (as animal)	Short-term toxicity	Resolve DOI
Nephrotoxicity	Urogenital: kidneys	Fruit unspecified	Solvent extraction	House mouse (as animal)	Short-term toxicity	Resolve DOI
Reproductive	Uterus	Unspecified	Solvent extraction	—	Case report	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Miyazawa, M., Kawata, J. Identification of the Key Aroma Compounds in Dried Roots of Rubia cordifolia. Journal of oleo science, 2006, vol. 55, no. 1, p. 37-39. DOI
Rasch, V., S�rensen, P.H., Wang, A.R., Tibazarwa, F., Jger, A.K. Unsafe abortion in rural Tanzania - The use of traditional medicine from a patient and a provider perspective. Bmc pregnancy and childbirth, 2014, vol. 14, no. 1. DOI
Anantharaman, Amrita., Priya, Rajendra Rao., Hemachandran, Hridya., Akella, Sivaramakrishna., Rajasekaran, Chandrasekaran., Ganesh, Jai., Fulzele, Devanand P., Siva, Ramamoorthy. Toxicity study of dibutyl phthalate of Rubia cordifolia fruits: in vivo and in silico analysis . Environmental toxicology, 2016, vol. 31, no. 9, p. 1059-1067. DOI
Rekha, S., Parvathi, A. Evaluation of phytochemical constituents of the roots of licorice, Indian ginseng, Indian madder and Indian Sarsaparilla. International Journal of Pharma and Bio Sciences, 2012, vol. 3, no. 2, p. 357-362.
Kinjal, Shah M., Dipal, Thumar D., Devang, Pandya J. Quality control parameters to detect adulteration of market samples of Indian Manjistha by Irani Manjistha . Indian journal of traditional knowledge, 2014, vol. 13, no. 2, p. 331-334.
Si, Nan., Yang, Jian., Wang, Hong-jie., Li, Peng-yue., Bian, Bao-lin., He, Xi-rong. HPLC Study on Rubia cordifolia L. contains toxic compositions of Lucidin and Lucidin-3-O-primeveroside. Zhongguo shiyan fangjixue zazhi, 2010, vol. 16, no. 6, p. 88-90.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

Continue

Independent literature