Ruta graveolens

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 111 licensed products naming Ruta graveolens as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

What the records describe

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

1. SCHIMMER, O., KIEFER, J., PAULINI, H. INHIBITORY EFFECTS OF FUROCOUMARINS IN SALMONELLA-TYPHIMURIUM TA98 ON THE MUTAGENICITY OF DICTAMNINE AND RUTACRIDONE, PROMUTAGENS FROM RUTA-GRAVEOLENS L . Mutagenesis, 1991, vol. 6, no. 6, p. 501-506. DOI
2. Wu, TS., Shi, LS., Wang, JJ., Iou, SC., Chang, HC., Chen, YP., Kuo, YH., Chang, YL., Teng, CM. Cytotoxic and antiplatelet aggregation principles of Ruta graveolens. Journal of the chinese chemical society, 2003, vol. 50, no. 1, p. 171-178.
3. Manjula, B.L., Sushma Mani, K. RP-HPLC analysis of furanocoumarins-psoralen, bergapten and xanthotoxin in Ruta graveolens L. International journal of pharmacognosy and phytochemical research, 2016, vol. 8, no. 2, p. 235-238.
4. Milesi, S., Massot, B., Gontier, E., Bourgaud, F., Guckert, A. Ruta graveolens L.: a promising species for the production of furanocoumarins . Plant science, 2001, vol. 161, no. 1, p. 189-199. DOI
5. Novak, Istvan., Szendrei, Kalman., Buzas, Geza., Minker, Emil., Koltai, Matyas. Isolation of the active substance from rutae radix. I. Acta pharmaceutica hungarica, 1967, vol. 37, no. 5, p. 225-9.
6. Al-Mahmoud, M.S., Elbetieha, A., Al-Muhur, R.A. Anticonceptive and antifertility activities of various Ruta graveolens extracts in female rats. Acta pharmaceutica turcica, 2003, vol. 45, no. 3, p. 203-212.
7. Ciganda, C., Laborde, A. Herbal infusions used for induced abortion. Journal of toxicology-clinical toxicology, 2003, vol. 41, no. 3, p. 235-239. DOI
8. de Carvalho, Alessandra Vargas., Luebeck, Irina., da Rocha, Mariana Balhego., Gueez, Camila Martins., Machado, Michel Mansur., Souza de Oliveira, Luis Flavio. Evaluation of the tickcide, genotoxic, and mutagenic effects of the Ruta graveolens L. (Rutaceae) . Acta scientiarum biological sciences, 2015, vol. 37, no. 4, p. 491-497. DOI
9. Andon, T. M., Denisova, G. A. Localization of coumarin compound in secretory receptacles of Ruta graveolens. Rastitel'nye resursy, 1974, vol. 10, no. 4, p. 528-40.
10. Logarto Parra, A., Silva Yhebra, R., Guerra Sardinas, I., Iglesias Buela, L. Comparative study of the assay of Artemia salina L. and the estimate of the medium lethal dose (LD50 value) in mice, to determine oral acute toxicity of plant extracts. . Phytomedicine : international journal of phytotherapy and phytopharmacology, 2001, vol. 8, no. 5, p. 395-400.
11. Hammiche, V., Azzouz, M. The Rues: ethnobotany, phytopharmacology and toxicity. Phytotherapie (paris), 2013, vol. 11, no. 1, p. 22-30. DOI

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