Botanical species · safety record

Sanguinaria canadensis

The EFSA Compendium of Botanicals holds 24 constituent measurements and 2 adverse-effect records for Sanguinaria canadensis. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Sanguinaria canadensis L.

24Constituent measurements

2Safety records

2Cited sources

94Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 94 licensed products naming Sanguinaria canadensis as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Source material stated

Adherent roots
Aerial parts
Dried rhizome
Dried underground part(s)
Dried underground parts collected in autumn
New material
Rhizome
Rhizome and dried roots

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Allocryptopine	Unspecified	Solvent extraction	≥ 5 Percent	Mass Spectroscopy and hyphenated methods without chromatography	Resolve DOI
Allocryptopine	Unspecified	Solvent extraction	≤ 8 Percent	Mass Spectroscopy and hyphenated methods without chromatography	Resolve DOI
Benzophenanthridine alkaloids	Unspecified	Solvent extraction	≥ 32 Percent	Mass Spectroscopy and hyphenated methods without chromatography	Resolve DOI
Benzophenanthridine alkaloids	Unspecified	Solvent extraction	≤ 35 Percent	Mass Spectroscopy and hyphenated methods without chromatography	Resolve DOI
Benzophenanthridine alkaloids	Unspecified	Solvent extraction	≥ 2 Percent	Mass Spectroscopy and hyphenated methods without chromatography	Resolve DOI
Benzophenanthridine alkaloids	Unspecified	Solvent extraction	—	Mass Spectroscopy and hyphenated methods without chromatography	Resolve DOI
Benzophenanthridine alkaloids	Unspecified	Solvent extraction	≤ 5 Percent	Mass Spectroscopy and hyphenated methods without chromatography	Resolve DOI
Benzophenanthridine alkaloids	Unspecified	Solvent extraction	≥ 10 Percent	Mass Spectroscopy and hyphenated methods without chromatography	Resolve DOI
Benzophenanthridine alkaloids	Unspecified	Solvent extraction	≤ 15 Percent	Mass Spectroscopy and hyphenated methods without chromatography	Resolve DOI
Protopine	Unspecified	Solvent extraction	≤ 5 Percent	Mass Spectroscopy and hyphenated methods without chromatography	Resolve DOI
Protopine	Unspecified	Solvent extraction	≥ 2 Percent	Mass Spectroscopy and hyphenated methods without chromatography	Resolve DOI
Sanguinarine	Unspecified	Solvent extraction	≤ 38 Percent	Mass Spectroscopy and hyphenated methods without chromatography	Resolve DOI
Sanguinarine	Unspecified	Solvent extraction	≥ 30 Percent	Mass Spectroscopy and hyphenated methods without chromatography	Resolve DOI
Benzophenanthridine alkaloids	Roots and other underground parts	Solvent extraction	≤ 1 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Benzophenanthridine alkaloids	Roots and other underground parts	Solvent extraction	≥ 5 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Benzophenanthridine alkaloids	Roots and other underground parts	Solvent extraction	15 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Benzophenanthridine alkaloids	Roots and other underground parts	Solvent extraction	≥ 3.5 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Benzophenanthridine alkaloids	Roots and other underground parts	Solvent extraction	≤ 4 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Benzophenanthridine alkaloids	Roots and other underground parts	Solvent extraction	≥ 0.5 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Benzophenanthridine alkaloids	Roots and other underground parts	Solvent extraction	≤ 32 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Chelerythrine	Roots and other underground parts	Solvent extraction	≤ 25 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Chelerythrine	Roots and other underground parts	Solvent extraction	≥ 24 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Sanguinarine	Roots and other underground parts	Solvent extraction	≤ 50 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Sanguinarine	Roots and other underground parts	Solvent extraction	≥ 40 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Other toxicities	—	Roots and other underground parts	Solvent extraction	Rat (as animal)	Acute toxicity	No resolvable identifier
Other toxicities	—	Roots and other underground parts	Solvent extraction	Rat (as animal)	Acute toxicity	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Becci, Peter J., Schwartz, Harold., Barnes, Hamlin H., Southard, G. Lee. Short-term toxicity studies of sanguinarine and of two alkaloid extracts of Sanguinaria canadensis L. Journal of toxicology and environmental health, 1987, vol. 20(1-2), p. 199-208.
BAMBAGIOTTIALBERTI, M., PINZAUTI, S., MONETI, G., GRATTERI, P., CORAN, SA., VINCIERI, FF. CHARACTERIZATION OF SANGUINARIA-CANADENSIS L FLUID EXTRACT BY FAB MASS-SPECTROMETRY . Journal of pharmaceutical and biomedical analysis, 1991, vol. 9, no. 10-12, p. 1083-1087. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature