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Botanical species · safety record

Sceletium tortuosum

The EFSA Compendium of Botanicals holds 18 constituent measurements for Sceletium tortuosum. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Sceletium tortuosum (L.) N.E. Br.

18Constituent measurements
0Safety records
6Cited sources
21Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 21 licensed products naming Sceletium tortuosum as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

  • Dry

Source material stated

  • Aerial parts
  • Flower
  • Herb top
  • Leaf
  • Leaf and stem
  • New material

What the records describe

Constituents measured

  • Alkaloids6
  • Mesembrenone4
  • Mesembrine4
  • Anthraquinones1
  • Coumarins1
  • Quinoline alkaloids1
  • Tannins1

Plant parts

  • Aerial part of plants10
  • Leaves4
  • Unspecified4

Preparations

  • Solvent extraction17

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

SubstancePlant partPreparationConcentrationAnalytical methodSource
AlkaloidsUnspecified——Mass Spectroscopy and hyphenated methods without chromatographyResolve DOI
AlkaloidsLeavesSolvent extraction529.48 Microgram/millilitreHPLC-DADResolve DOI
AlkaloidsAerial part of plantsSolvent extraction≤ 95.55 PercentGC-MSResolve DOI
AlkaloidsAerial part of plantsSolvent extraction≥ 64.96 PercentGC-MSResolve DOI
AlkaloidsLeavesSolvent extraction253.55 Microgram/millilitreHPLC-DADResolve DOI
AlkaloidsAerial part of plantsSolvent extraction—Phytochemical screeningResolve DOI
AnthraquinonesAerial part of plantsSolvent extraction—Phytochemical screeningResolve DOI
CoumarinsAerial part of plantsSolvent extraction—Phytochemical screeningResolve DOI
MesembrenoneAerial part of plantsSolvent extraction≥ 50.86 PercentGC-MSResolve DOI
MesembrenoneAerial part of plantsSolvent extraction≤ 72.51 PercentGC-MSResolve DOI
MesembrenoneLeavesSolvent extraction351.69 Microgram/millilitreHPLC-DADResolve DOI
MesembrenoneUnspecifiedSolvent extraction—Nuclear Magnetic Resonance (NMR)Resolve DOI
MesembrineAerial part of plantsSolvent extraction≥ 51.25 PercentGC-MSResolve DOI
MesembrineAerial part of plantsSolvent extraction≤ 92.5 PercentGC-MSResolve DOI
MesembrineLeavesSolvent extraction135.08 Microgram/millilitreHPLC-DADResolve DOI
MesembrineUnspecifiedSolvent extraction—Nuclear Magnetic Resonance (NMR)Resolve DOI
Quinoline alkaloidsUnspecifiedSolvent extraction—Chromatographic testsResolve DOI
TanninsAerial part of plantsSolvent extraction—Phytochemical screeningResolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

  1. Lesiak, Ashton D., Cody, Robert B., Ubukata, Masaaki., Musah, Rabi A. Direct analysis in real time high resolution mass spectrometry as a tool for rapid characterization of mind-altering plant materials and revelation of supplement adulteration - The case of Kanna . Forensic science international, 2016, vol. 260, p. 66-73. DOI
  2. Shikanga, Emmanuel Amukohe., Viljoen, Alvaro M., Combrinck, Sandra., Marston, Andrew., Gericke, Nigel. The chemotypic variation of Sceletium tortuosum alkaloids and commercial product formulations . Biochemical systematics and ecology, 2012, vol. 44, p. 364-373. DOI
  3. Kapewangolo, P., Tawha, T., Nawinda, T., Knott, M., Hans, R. Sceletium tortuosum demonstrates in vitro anti-HIV and free radical scavenging activity . South african journal of botany, 2016, vol. 106, p. 140-143. DOI
  4. Shikanga, E. A., Kamatou, G. P. P., Chen, W., Combrinck, S., Viljoen, A. M. Validated RP-UHPLC PDA and GC-MS methods for the analysis of psychoactive alkaloids in Sceletium tortuosum . South african journal of botany, 2012, vol. 82, p. 99-107. DOI
  5. Meyer, Golo M. J., Wink, Carina S. D., Zapp, Josef., Maurer, Hans H. GC-MS, LC-MSn, LC-high resolution-MSn, and NMR studies on the metabolism and toxicological detection of mesembrine and mesembrenone, the main alkaloids of the legal high Kanna isolated from Sceletium tortuosum . Analytical and bioanalytical chemistry, 2015, vol. 407, no. 3, p. 761-778. DOI
  6. SNYCKERS, FO., STRELOW, F., WIECHERS, A. STRUCTURES OF PARTIAL RACEMIC SCELETIUM ALKALOID A4 AND TORTUOSAMINE, PYRIDINE ALKALOIDS FROM SCELETIUM-TORTUOSUM NE BR . Journal of the chemical society d-chemical communications, 1971, no. 22, p. 1467-&. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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