Botanical species · safety record

Securigera varia

The EFSA Compendium of Botanicals holds 15 constituent measurements and 4 adverse-effect records for Securigera varia. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Securigera varia (L.) Lassen

15Constituent measurements

4Safety records

9Cited sources

0Licensed products (Canada)

Also recorded as

Coronilla varia L.

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Coumarins	Seed	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Hyrcanoside	Seed	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Proanthocyanidins (condensed tannins)	—	Solvent extraction	3 Percent	UV/VIS spectroscopy (photometry)	Resolve DOI
Daphnoretin	Roots and other underground parts	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Daphnoretin	Seed	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Deglucohyrcanoside	Seed	Solvent extraction	—	Unspecified	No resolvable identifier
Genistein	Aerial part of plants	Solvent extraction	0.34 Microgram/millilitre	HPLC with standard detection methods	No resolvable identifier
Genistin	Aerial part of plants	Solvent extraction	1.1 Microgram/millilitre	HPLC with standard detection methods	No resolvable identifier
Hyrcanoside	Seed	Solvent extraction	—	Unspecified	No resolvable identifier
P-coumaric acid	Seed	Solvent extraction	—	Chromatographic tests	No resolvable identifier
Proanthocyanidins (condensed tannins)	Aerial part of plants	Solvent extraction	23.2 Gram/100 gram	Chromatographic tests	No resolvable identifier
Scopoletin	Live plants	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Scopoletin	Seed	Solvent extraction	—	Chromatographic tests	No resolvable identifier
Umbelliferone	Live plants	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Umbelliferone	Seed	Solvent extraction	—	Chromatographic tests	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Neurotoxicity	Neurologic	Aerial part of plants	—	Bird (as animal)	Case report	Resolve DOI
Neurotoxicity	Neurologic	Aerial part of plants	—	Gallus gallus (chicken) (as animal)	Short-term toxicity	No resolvable identifier
Neurotoxicity	Neurologic	Aerial part of plants	—	Rodents (as animal)	Short-term toxicity	No resolvable identifier
Neurotoxicity	Neurologic	Aerial part of plants	—	Pig (as animal)	Short-term toxicity	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Hanganu, Daniela., Vlase, Laurian., Olah, Neli. Phytochemical Analysis of Isoflavons from some Fabaceae Species Extracts. Notulae botanicae horti agrobotanici cluj-napoca, 2010, vol. 38, no. 1, p. 57-60.
SHENK, JS., WANGSNESS, PJ., LEACH, RM., GUSTINE, DL., GOBBLE, JL., BARNES, RF. RELATIONSHIP BETWEEN B-NITROPROPIONIC ACID CONTENT OF CROWNVETCH AND TOXICITY IN NON-RUMINANT ANIMALS . Journal of animal science, 1976, vol. 42, no. 3, p. 616-621.
Joo, Pilju K., McKee, G. W., MacDonald, H. A., Langille, R. A. Isolation and identification of phytotoxic substances from seeds of Coronilla varia L. Proceedings of the association of official seed analysts, 1975, vol. 65, p. 38-51.
Brown, Ron H., Mueller-Harvey, Irene., Zeller, Wayne E., Reinhardt, Laurie., Stringano, Elisabetta., Gea, An., Drake, Christopher., Ropiak, Honorata M., Fryganas, Christos., Ramsay, Aina., . Facile Purification of Milligram to Gram Quantities of Condensed Tannins According to Mean Degree of Polymerization and Flavan-3-ol Subunit Composition. Journal of agricultural and food chemistry, 2017, vol. 65, no. 36, p. 8072-8082.
TERRILL, TH., ROWAN, AM., DOUGLAS, GB., BARRY, TN. DETERMINATION OF EXTRACTABLE AND BOUND CONDENSED TANNIN CONCENTRATIONS IN FORAGE PLANTS, PROTEIN-CONCENTRATE MEALS AND CEREAL-GRAINS . Journal of the science of food and agriculture, 1992, vol. 58, no. 3, p. 321-329. DOI
Innocenti, G., Piovan, A., Caniato, R., Filippini, R., Cappelletti, EM. Within-plant distribution of coumarins in Coronilla and Securigera species . International journal of pharmacognosy, 1996, vol. 34, no. 2, p. 114-118.
Campbell, Terry W. Crown Vetch (Coronilla varia) poisoning in a budgerigar (Melopsittacus undulatus) . Journal of avian medicine and surgery, 2006, vol. 20, no. 2, p. 97-100. DOI
Komissarenko, N.F. Cardenolides and coumarins of Coronilla varia, C. cretica, etc.. Chemistry of natural compounds, 1969, vol. 5, no. 3, p. 121-123. DOI
Slavik, J., Zackova, P., Michlova, J., Opletal, L., Sovova, M. Phytotherapeutic aspects of the diseases of the circulatory system. Cardiotonic and cardiotoxic effects of hyrcanoside and deglucohyrcanoside isolated from Coronilla varia L. Ceska a slovenska farmacie, 1994, vol. 43, no. 6), 29, p. 302.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature