Botanical species · safety record

Senecio vulgaris

The EFSA Compendium of Botanicals holds 7 constituent measurements and 2 adverse-effect records for Senecio vulgaris. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Senecio vulgaris L.

7Constituent measurements

2Safety records

5Cited sources

0Licensed products (Canada)

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Pyrrolizidine alkaloids	Unspecified	Solvent extraction	—	Unspecified	Resolve DOI
Pyrrolizidine alkaloids	Live plants	Solvent extraction	0.14 Percent	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Pyrrolizidine alkaloids	Live plants	Solvent extraction	0.16 Percent	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Retrorsine	Unspecified	Solvent extraction	65 Microgram/gram	LC-MS	No resolvable identifier
Seneci(o)phylline	Unspecified	Solvent extraction	12.3 Microgram/gram	LC-MS	No resolvable identifier
Senecionine	Unspecified	Solvent extraction	40 Microgram/gram	LC-MS	No resolvable identifier
Senkirkine	Live plants	Solvent extraction	0.013 Microgram/gram	LC-MS	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Hepatotoxicity	Liver	Live plants	Solvent extraction	Rat (as animal)	Short-term toxicity	Resolve DOI
Hepatotoxicity	Liver	Aerial part of plants	Fresh	Horse (as animal)	Case report	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Zhou, Yan., Li, Na., Choi, Franky Fung-Kei., Qiao, Chun-Feng., Song, Jing-Zheng., Li, Song-Lin., Liu, Xin., Cai, Zong-Wei., Fu, Peter P., Lin, Ge., et al. A new approach for simultaneous screening and quantification of toxic pyrrolizidine alkaloids in some potential pyrrolizidine alkaloid-containing plants by using ultra performance liquid chromatography-tandem quadrupole mass spectrometry. Analytica Chimica Acta, 2010, p. 33-40.
Lessard P., Wilson W D., Olander H J., Rogers Q R., Mendel V E. Clinicopathologic study of horses surviving pyrrolizidine alkaloid (Senecio vulgaris) toxicosis. American journal of veterinary research, 1986, p. 1776-1780.
Xiong, Aizhen., Fang, Lianxiang., Yang, Xiao., Yang, Fan., Qi, Meng., Kang, Hong., Yang, Li., Tsim, Karl Wah-Keung., Wang, Zhengtao. An application of target profiling analyses in the hepatotoxicity assessment of herbal medicines: comparative characteristic fingerprint and bile acid profiling of Senecio vulgaris L. and Senecio scandens Buch.-Ham. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2014, vol. 406, no. 29, p. 7715-7727. DOI
Molyneux, Russell J., Johnson, A. Earl., Roitman, James N., Benson, Mabry E. Chemistry of toxic range plants. Determination of pyrrolizidine alkaloid content and composition in Senecio species by nuclear magnetic resonance spectroscopy. Journal of Agricultural and Food Chemistry, 1979, p. 494-499.
Roeder, E., Wiedenfeld, H. Plants containing pyrrolizidine alkaloids used in the Traditional Indian Medicine - including Ayurveda. PHARMAZIE, 2013, vol. 68, no. 2, p. 83-92. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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