Botanical species · safety record

Senna alexandrina

The EFSA Compendium of Botanicals holds 4 constituent measurements and 3 adverse-effect records for Senna alexandrina. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Senna alexandrina Mill.

4Constituent measurements

3Safety records

5Cited sources

449Licensed products (Canada)

Also recorded as

Cassia acutifolia Delile
Cassia angustifolia Vahl
Cassia senna L.

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 449 licensed products naming Senna alexandrina as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Dry
Extract Type TBA

Source material stated

Aged bark
Dried fruit
Dried leaf
Dried leaflet
Dried leaflets
Fruit
Fruit and leaf
Fruit(s)

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
1,8-cineole	Leaves	Solvent extraction	26.55 Percent Area	GC-MS	Resolve DOI
Aloe-emodin	Unspecified	Solvent extraction	—	Unspecified	Resolve DOI
Sennoside a	Seed	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Sennoside b	Seed	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Hepatotoxicity	Liver	Fruit unspecified	Solvent extraction	Human (as organism)	Case report	Resolve DOI
Systemic	—	Fruit unspecified	Fresh	Gallus gallus (chicken) (as animal)	Subchronic	No resolvable identifier
Systemic	—	Fruit unspecified	Fresh	Gallus gallus (chicken) (as animal)	Subchronic	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Derbalah, Aly S. Efficacy of some botanical extracts against Trogoderma granarium in wheat grains with toxicity evaluation. . Thescientificworldjournal, 2012, vol. 2012, p. 639854-639854. DOI
Kapadia, Govind J., Khorana, M. L. Paper chromatographic separation of sennoside A and sennoside B. Journal of Chromatography, 1961, p. 537-538.
Omer, Sawsan A., Al-Olayan, Ebtesam M., El-Amin, Maha H., Hassan, Zeinab K., Daghestani, Maha H., Mohammed, Osama B. Experimental Cassia senna intoxication in Lohmann broiler chicks. Journal of Medicinal Plants Research, 2012, p. 3306-3310.
Vanderperren, B., Rizzo, M., Angenot, L., Haufroid, V., Jadoul, M., Hantson, P. Acute liver failure with renal impairment related to the abuse of senna anthraquinone glycosides. ANNALS OF PHARMACOTHERAPY, 2005, vol. 39, no. 7-8, p. 1353-1357. DOI
Zhou, J., Ouedraogo, M., Qu, F., Duez, P. Potential genotoxicity of traditional Chinese medicinal plants and phytochemicals: An overview. Phytotherapy Research, 2013, vol. 27, no. 12, p. 1745-1755. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature