Botanical species · safety record
Senna italica
The EFSA Compendium of Botanicals holds 8 constituent measurements and 6 adverse-effect records for Senna italica. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.
Accepted name in source: Senna italica Mill.
Also recorded as
Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.
Regulatory presence
No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.
What the records describe
Constituents measured
- Alkaloids1
- Aloin a1
- Anthraquinones1
- Emodin1
- Oxalates1
- Saponins1
- Sennoside a1
- Sennoside b1
Plant parts
- Seed5
- Leaves4
- Unspecified3
- Aerial part of plants2
Preparations
- Solvent extraction9
Effect types
- Hemopoietic2
- Digestive1
- Hepatotoxicity1
- Nephrotoxicity1
- Pulmonary and cardiac1
Target tissues
- Heart2
- Cardiovascular1
- Digestive1
- Liver1
- Urogenital: kidneys1
- haematological1
Recorded constituents
What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.
| Substance | Plant part | Preparation | Concentration | Analytical method | Source |
|---|---|---|---|---|---|
| Aloin a | Aerial part of plants | Solvent extraction | — | Nuclear Magnetic Resonance (NMR) | Resolve DOI |
| Emodin | Aerial part of plants | Solvent extraction | — | Nuclear Magnetic Resonance (NMR) | Resolve DOI |
| Alkaloids | Leaves | Solvent extraction | 4.33 Percent | Phytochemical screening | No resolvable identifier |
| Anthraquinones | Unspecified | Solvent extraction | — | Unspecified | No resolvable identifier |
| Oxalates | Leaves | Solvent extraction | 0.81 Percent | Phytochemical screening | No resolvable identifier |
| Saponins | Leaves | Solvent extraction | 6.33 Milligram/gram | Phytochemical screening | No resolvable identifier |
| Sennoside a | Unspecified | Solvent extraction | — | Unspecified | No resolvable identifier |
| Sennoside b | Unspecified | Solvent extraction | — | Unspecified | No resolvable identifier |
Recorded adverse effects
Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.
| Effect | Target tissue | Plant part | Preparation | Test organism | Test type | Source |
|---|---|---|---|---|---|---|
| Digestive | Digestive | Seed | — | Gallus gallus (chicken) (as animal) | Case report | Resolve DOI |
| Hemopoietic | Heart | Seed | — | Gallus gallus (chicken) (as animal) | Case report | Resolve DOI |
| Hemopoietic | Cardiovascular / haematological | Seed | — | Gallus gallus (chicken) (as animal) | Case report | Resolve DOI |
| Hepatotoxicity | Liver | Seed | — | Gallus gallus (chicken) (as animal) | Case report | Resolve DOI |
| Nephrotoxicity | Urogenital: kidneys | Seed | — | Gallus gallus (chicken) (as animal) | Case report | Resolve DOI |
| Pulmonary and cardiac | Heart | Leaves | Solvent extraction | Human (as organism) | Case report | Resolve DOI |
Cited sources
The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.
- Bakhiet, AO., Adam, SEI. Toxicity to bovans chicks of Cassia italica seeds. Phytotherapy research, 1996, vol. 10, no. 2, p. 156-160. DOI
- Mohamed, Gamal A. New cytotoxic cycloartane triterpene from Cassia italica aerial parts. Natural product research, 2014, vol. 28, no. 13, p. 976-983. DOI
- Nazirizadeh, M., Amin, G. H. Studies of drugs from Senna (Cassia italica) plants in Iran. Iranian journal of chemistry chemical engineering, 1985, p. 68-72.
- Nadro, M. S., Onoagbe, I. O. Chemical constituents of ethanolic extract of Cassia italica leaf. Asian journal of biochemical and pharmaceutical research, 2014, p. 328-334.
- El-Menyar, Ayman A., Helmy, Ashraf H., Mubarak, Nagi M., Arafa, Salah E. O. Acute myocardial infarction with patent epicardial coronary vessels following Cassia italica ingestion . Cardiovascular toxicology, 2006, vol. 6, no. 2, p. 81-84. DOI
- Jain, S. C., Sharma, R. A., Jain, R. Sennosides in Cassia italica in vivo and in vitro. Fitoterapia, 1996.
Boundary
A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.
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