Botanical species · safety record

Sida acuta

The EFSA Compendium of Botanicals holds 23 constituent measurements and 25 adverse-effect records for Sida acuta. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Sida acuta Burm.f.

23Constituent measurements
25Safety records
14Cited sources
0Licensed products (Canada)

Also recorded as

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

  • Alkaloids3
  • Saponins2
  • Vasicinone2
  • Acanthoside b1
  • Calcium oxalate1
  • Cardiac glycosides1
  • Cryptolepine1
  • Ephedrine1
  • Gallic acid1
  • Heraclenol1

Plant parts

  • Aerial part of plants20
  • Leaves17
  • Unspecified8
  • Roots and other underground parts3

Preparations

  • Solvent extraction19
  • Fresh17
  • Powder9

Effect types

  • Neurotoxicity8
  • Nephrotoxicity5
  • Digestive2
  • Hemopoietic2
  • Other toxicities2
  • Reproductive2
  • Systemic2
  • Endocrine1
  • Immunotoxicity1

Target tissues

  • Cardiovascular5
  • Urogenital: kidneys4
  • Neurologic3
  • Neurologic: central nervous system3
  • haematological: lymph nodes3
  • Brain2
  • Digestive2
  • Liver2
  • Uterus2
  • haematological2

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

SubstancePlant partPreparationConcentrationAnalytical methodSource
CryptolepineAerial part of plantsSolvent extraction12.54 Microgram/gramHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)Resolve DOI
Acanthoside bAerial part of plantsColorimetry, Spectroscopy (Spectrometry) and PhotometryNo resolvable identifier
AlkaloidsLeavesPowderPhytochemical screeningNo resolvable identifier
AlkaloidsLeavesPowder523 Milligram/100 gramPhytochemical screeningNo resolvable identifier
AlkaloidsLeavesSolvent extractionPhytochemical screeningNo resolvable identifier
Calcium oxalateLeavesPowderMicroscopic detectionNo resolvable identifier
Cardiac glycosidesLeavesPowderPhytochemical screeningNo resolvable identifier
EphedrineUnspecifiedSolvent extraction0.86 PercentGelpermeation, High Performance Thin Layer Chromatography (HPTLC)No resolvable identifier
Gallic acidLeavesSolvent extraction2.9 Microgram/gramUHPLC-MS-MSNo resolvable identifier
HeraclenolAerial part of plantsColorimetry, Spectroscopy (Spectrometry) and PhotometryNo resolvable identifier
Hydrocyanic acidLeavesPowder98.25 Milligram/100 gramPhytochemical screeningNo resolvable identifier
OxalatesLeavesPowder140.8 Milligram/100 gramPhytochemical screeningNo resolvable identifier
PeganineRoots and other underground partsSolvent extraction0.008 PercentGelpermeation, High Performance Thin Layer Chromatography (HPTLC)No resolvable identifier
PhlobotanninsLeavesSolvent extractionPhytochemical screeningNo resolvable identifier
Phytic acidLeavesPowder210.07 Milligram/100 gramPhytochemical screeningNo resolvable identifier
Saponin glycosidesLeavesPowderPhytochemical screeningNo resolvable identifier
SaponinsLeavesSolvent extractionPhytochemical screeningNo resolvable identifier
SaponinsLeavesPowder650 Milligram/100 gramPhytochemical screeningNo resolvable identifier
SwainsonineUnspecifiedNo resolvable identifier
TanninsLeavesSolvent extractionPhytochemical screeningNo resolvable identifier
UmbelliferoneLeavesSolvent extraction668.7 Microgram/gramUHPLC-MS-MSNo resolvable identifier
VasicinoneRoots and other underground partsSolvent extraction≤ 0.0026 PercentGelpermeation, High Performance Thin Layer Chromatography (HPTLC)No resolvable identifier
VasicinoneRoots and other underground partsSolvent extraction≥ 0.0023 PercentGelpermeation, High Performance Thin Layer Chromatography (HPTLC)No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

EffectTarget tissuePlant partPreparationTest organismTest typeSource
EndocrineGlandular: thyroidAerial part of plantsFreshCattle (as animal)Case reportResolve DOI
ImmunotoxicityCardiovascular / haematological: lymph nodesAerial part of plantsFreshCase reportResolve DOI
NephrotoxicityUrogenital: kidneysAerial part of plantsFreshGoat (as animal)Reproduction toxicityResolve DOI
NephrotoxicityUrogenital: kidneysAerial part of plantsFreshGoat (as animal)Reproduction toxicityResolve DOI
NephrotoxicityDigestive: pancreasAerial part of plantsFreshCase reportResolve DOI
NephrotoxicityUrogenital: kidneysAerial part of plantsFreshCattle (as animal)Case reportResolve DOI
NeurotoxicityNeurologic: central nervous systemAerial part of plantsFreshGoat (as animal)Reproduction toxicityResolve DOI
NeurotoxicityNeurologic: central nervous systemAerial part of plantsFreshGoat (as animal)Reproduction toxicityResolve DOI
NeurotoxicityBrainAerial part of plantsFreshCase reportResolve DOI
NeurotoxicityNeurologic: central nervous systemAerial part of plantsFreshCase reportResolve DOI
NeurotoxicityNeurologicAerial part of plantsFreshCattle (as animal)Case reportResolve DOI
Other toxicitiesCardiovascular / haematological: lymph nodesAerial part of plantsFreshGoat (as animal)Short-term toxicityResolve DOI
Other toxicitiesCardiovascular / haematological: lymph nodesAerial part of plantsFreshGoat (as animal)Short-term toxicityResolve DOI
DigestiveLiverUnspecifiedSolvent extractionRat (as animal)Short-term toxicityNo resolvable identifier
DigestiveLiverUnspecifiedSolvent extractionRat (as animal)Short-term toxicityNo resolvable identifier
HemopoieticCardiovascular / haematologicalUnspecifiedSolvent extractionRat (as animal)Short-term toxicityNo resolvable identifier
HemopoieticCardiovascular / haematologicalUnspecifiedSolvent extractionRat (as animal)Short-term toxicityNo resolvable identifier
NephrotoxicityUrogenital: kidneysAerial part of plantsFreshHorse (as animal)Case reportNo resolvable identifier
NeurotoxicityNeurologicAerial part of plantsFreshRuminants (generic) (as animal)Case reportNo resolvable identifier
NeurotoxicityBrainAerial part of plantsFreshHorse (as animal)Case reportNo resolvable identifier
NeurotoxicityNeurologicAerial part of plantsFreshHorse (as animal)Case reportNo resolvable identifier
ReproductiveUterusLeavesSolvent extractionRat (as animal)Reproduction toxicityNo resolvable identifier
ReproductiveUterusLeavesSolvent extractionRat (as animal)Reproduction toxicityNo resolvable identifier
SystemicDigestiveUnspecifiedSolvent extractionRat (as animal)Short-term toxicityNo resolvable identifier
SystemicDigestiveUnspecifiedSolvent extractionRat (as animal)Short-term toxicityNo resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

  1. Konate Kiessoun., Bassole Imael Henri Nestor., Hilou Adama., Aworet-Samseny Raissa R R., Souza Alain., Barro Nicolas., Dicko Mamoudou H., Datte Jacques Y., M'Batchi Bertrand. Toxicity assessment and analgesic activity investigation of aqueous acetone extracts of Sida acuta Burn f . and Sida cordifolia L. (Malvaceae), medicinal plants of Burkina Faso. Bmc complementary and alternative medicine, 2012, vol. 12, p. 120.
  2. Dhalwal, Kamlesh., Shinde, Vaibhav M., Mahadik, Kakasaheb R. Optimization and validation of reverse phase HPLC and HPTLC method for simultaneous quantification of vasicine and vasicinone in Sida Species . Journal of medicinal plants research, 2010, vol. 4, no. 13, p. 1289-1296.
  3. Kumar, V., Sharma, A., Bhardwaj, R., Thukral, Ashwani Kumar. Polyphenol profiling in the leaves of plants from the catchment area of river Beas, India. International journal of pharma and bio sciences, 2015, vol. 6, no. 4, p. 1005-1012.
  4. Adeniyi, S. A., Orjiekwe, C. L., Ehiagbonare, J. E., Arimah, B. D. Preliminary phytochemical analysis and insecticidal activity of ethanolic extracts of four tropical plants (Vernonia amygdalina, Sida acuta, Ocimum gratissimum and Telfaria occidentalis) against beans weevil (Acanthscelides obtectus) . International journal of the physical sciences, 2010, vol. 5, no. 6, p. 753-762.
  5. Anjos, Bruno L., Peixoto, Paulo V., Graca, Flavio A. S., Caldas, Saulo A., Bhaltazar, Daniel., Franca, Ticiana N., Armien, Anibal G. POISONING BY THE SWAINSONINE-CONTAINING PLANT SIDA CARPINIFOLIA IN CAPTIVE SAMBAR DEER (CERVUS UNICOLOR) . Journal of zoo and wildlife medicine, 2016, vol. 47, no. 3, p. 862-867.
  6. Londonkar, R.L., Patil, S.J., Patil, S.B. Phytochemical and contraceptive property of Sida acuta Burm FI. IIN. in albio rats. International journal of pharmtech research, 2009, vol. 1, no. 4, p. 1260-1266.
  7. Enin, G. N., Antia, B. S., Enin, F. G. Chemical assessment of the proximate, minerals and anti-nutrients composition of Sida acuta leaves. Elixir international journal, 2014, vol. (June), 24654-24660, p. 7 pp.
  8. Oboh, I.E., Onwukaeme, D.N. Pharmacognostic evaluation of the leaves of Sida acuta Burm.F. (Malvaceae). Journal of phytomedicine and therapeutics, 2007, vol. 12, p. 56-65.
  9. Cao, J H., Qi, Y P. Studies on the chemical constituents of the herb huanghuaren (Sida acuta Burm. f.) . . Zhongguo zhong yao za zhi = zhongguo zhongyao zazhi = china journal of chinese materia medica, 1993, vol. 18, no. 11, p. 681-703.
  10. Zafar, Rasheed-uz., Ahmad, Sayeed. HPTLC finger prints of Ephedra gerardiana wall and Sida acuta burm. Analytical chemistry: an indian journal, 2006, vol. 2(5-6), p. 212-215.
  11. Chatterjee, Arnab., Kumar, Satyanshu., Chattopadhyay, Sunil K. A validated HPLC-PDA method for identification and quantification of two bioactive alkaloids, ephedrine and cryptolepine, in different Sida species . Biomedical chromatography, 2013, vol. 27, no. 12, p. 1720-1725. DOI
  12. Pedroso, P.M.O., Von Hohendorf, R., De Oliveira, L.G.S., Schmitz, M., Da Cruz, C.E.F., Driemeier, D. SID a carpinifolia (Malvaceae) poisoning in fallow deer (Dama Dama). Journal of zoo and wildlife medicine, 2009, vol. 40, no. 3, p. 583-585. DOI
  13. Pedroso, P.M., Colodel, E.M., Seitz, A.L., Correa, G.L., Soares, M.P., Driemeier, D. Pathological findings in fetuses of goats and cattle poisoned by Sida carpinifolia (malvaceae). Pesquisa veterinaria brasileira, 2012, vol. 32, no. 3, p. 227-230. DOI
  14. Loretti, A.P., Colodel, E.M., Gimeno, E.J., Driemeier, D. Lysosomal storage disease in Sida carpinifolia toxicosis: An induced mannosidosis in horses. Equine veterinary journal, 2003, vol. 35, no. 5, p. 434-438.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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