Botanical species · safety record

Sida cordifolia

The EFSA Compendium of Botanicals holds 11 constituent measurements and 1 adverse-effect record for Sida cordifolia. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Sida cordifolia L.

11Constituent measurements

1Safety records

6Cited sources

9Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 9 licensed products naming Sida cordifolia as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Source material stated

Aerial parts
Root
Whole
Whole plant

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Ephedrine	Aerial part of plants	Solvent extraction	0.112 Percent	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	Resolve DOI
Ephedrine	Roots and other underground parts	Solvent extraction	0.007 Percent	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	Resolve DOI
Cryptolepine	Live plants	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Ephedrine	Unspecified	—	—	Unspecified	No resolvable identifier
Ephedrine	Roots and other underground parts	Solvent extraction	≤ 0.048 Percent	HPLC-UV	No resolvable identifier
Ephedrine	Roots and other underground parts	Solvent extraction	≥ 2e-04 Percent	HPLC-UV	No resolvable identifier
Peganine	Roots and other underground parts	Solvent extraction	≤ 0.011 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Peganine	Roots and other underground parts	Solvent extraction	≥ 0.01 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Pseudoephedrine	Unspecified	—	—	Unspecified	No resolvable identifier
Vasicinone	Roots and other underground parts	Solvent extraction	≤ 0.065 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Vasicinone	Roots and other underground parts	Solvent extraction	≥ 0.061 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Musclo-skeletal	Neurologic	Leaves	Solvent extraction	House mouse (as animal)	Acute toxicity	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Cotten, Steven W., Hammett-Stabler, Catherine A. Risk of toxicity associated with unregulated herbal products. Herbal supplements, 2011, p. 45-72.
Latha, A., Radhakrishnan, V.V. Variation in root yield and ephedrine content of Bala (Sida cordifolia Linn.) at differential harvesting under open and shaded situation. Journal of tropical agriculture, 2015, vol. 53, no. 1, p. 42-47.
Dhalwal, Kamlesh., Shinde, Vaibhav M., Mahadik, Kakasaheb R. Optimization and validation of reverse phase HPLC and HPTLC method for simultaneous quantification of vasicine and vasicinone in Sida Species . Journal of medicinal plants research, 2010, vol. 4, no. 13, p. 1289-1296.
Khatoon, S., Srivastava, M., Rawat, AKS., Mehrotra, S. HPTLC method for chemical standardization of Sida species and estimation of the alkaloid ephedrine . Jpc-journal of planar chromatography-modern tlc, 2005, vol. 18, no. 105, p. 364-367. DOI
Matsui, Taka-Aki., Sowa, Yoshihiro., Murata, Hiroaki., Takagi, Koichi., Nakanishi, Ryoko., Aoki, Shunji., Yoshikawa, Masayuki., Kobayashi, Motomasa., Sakabe, Tomoya., Kubo, Toshikazu., Sakai, Toshiyuki. The plant alkaloid cryptolepine induces p21(WAF1/C1P1) and cell cycle arrest in a human osteosarcoma cell line . International journal of oncology, 2007, vol. 31, no. 4, p. 915-922.
Franco, CIF., Morais, LCSL., Quintans-Junior, LJ., Almeida, RN., Antoniolli, AR. CNS pharmacological effects of the hydroalcoholic extract of Sida cordifolia L. leaves . Journal of ethnopharmacology, 2005, vol. 98, no. 3, p. 275-279. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature