Botanical species · safety record

Sophora flavescens

The EFSA Compendium of Botanicals holds 5 constituent measurements, 1 adverse-effect record and 1 genotoxicity assay for Sophora flavescens. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Sophora flavescens Aiton

5Constituent measurements

2Safety records

2Cited sources

165Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 165 licensed products naming Sophora flavescens as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Dry
Extract Type TBA

Source material stated

Dried root(s)
Root
Root (carbonized)
Root (standardized extract)
standardized extract

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Matrine	Roots and other underground parts	Solvent extraction	18.2 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Matrine	Roots and other underground parts	Solvent extraction	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Oxymatrine	Roots and other underground parts	Solvent extraction	42.7 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Oxymatrine	Roots and other underground parts	Solvent extraction	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Quinolizidine alkaloids	Roots and other underground parts	Solvent extraction	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Systemic	Liver	Roots and other underground parts	Solvent extraction	Rat (as animal)	Subchronic	Resolve DOI

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	chromosome aberration	chromosome aberration assay	Hamster (as animal)	With	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Che, Jeong-Hwan., Yun, Jun-Won., Kim, Yun-Soon., Kim, Seung-Hyun., You, Ji-Ran., Jang, Ja-June., Kim, Hee Chan., Kim, Hyeon Hoe., Kang, Byeong-Cheol. Genotoxicity and subchronic toxicity of Sophorae radix in rats: Hepatotoxic and genotoxic potential . Regulatory toxicology and pharmacology, 2015, vol. 71, no. 3, p. 379-387. DOI
Wang Lei., Wu Xing-De., He Juan., Li Gen-Tao., Peng Li-Yan., Li Yan., Song Liu-Dong., Zhao Qin-Shi. A New Quinolizidine Alkaloid from Sophora flavescens. Chemistry of natural compounds, 2014, vol. 50, no. 5, p. 876-879. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature