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Botanical species · safety record

Stephania glabra

The EFSA Compendium of Botanicals holds 13 constituent measurements for Stephania glabra. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Stephania glabra (Roxb.) Miers

13Constituent measurements
0Safety records
9Cited sources
1Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 1 licensed products naming Stephania glabra as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Source material stated

  • Tuber

What the records describe

Constituents measured

  • Alkaloids5
  • Tetrahydropalmatin3
  • Cycleanine2
  • Aporphine alkaloids1
  • Isoflavones1
  • Protoberberine1

Plant parts

  • Roots and other underground parts8
  • Roots and other underground parts used as staple food4
  • Bulb1
  • clove1

Preparations

  • Solvent extraction13

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

SubstancePlant partPreparationConcentrationAnalytical methodSource
AlkaloidsRoots and other underground parts used as staple foodSolvent extraction—IR and Raman SpectroscopyResolve DOI
AlkaloidsRoots and other underground parts used as staple foodSolvent extraction—Colorimetry, Spectroscopy (Spectrometry) and PhotometryResolve DOI
Aporphine alkaloidsRoots and other underground partsSolvent extraction—IR and Raman SpectroscopyResolve DOI
CycleanineRoots and other underground parts used as staple foodSolvent extraction—IR and Raman SpectroscopyResolve DOI
ProtoberberineRoots and other underground partsSolvent extraction—IR and Raman SpectroscopyResolve DOI
TetrahydropalmatinRoots and other underground parts used as staple foodSolvent extraction—IR and Raman SpectroscopyResolve DOI
AlkaloidsRoots and other underground partsSolvent extraction2.99 PercentNuclear Magnetic Resonance (NMR)No resolvable identifier
AlkaloidsRoots and other underground partsSolvent extraction—Chromatographic testsNo resolvable identifier
AlkaloidsRoots and other underground partsSolvent extraction—UnspecifiedNo resolvable identifier
CycleanineBulb / cloveSolvent extraction—Colorimetry, Spectroscopy (Spectrometry) and PhotometryNo resolvable identifier
IsoflavonesRoots and other underground partsSolvent extraction—UnspecifiedNo resolvable identifier
TetrahydropalmatinRoots and other underground partsSolvent extraction1.65 PercentNuclear Magnetic Resonance (NMR)No resolvable identifier
TetrahydropalmatinRoots and other underground partsSolvent extraction—UnspecifiedNo resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

  1. Pal, Mahesh., Chaudhuri, P. K., Sharma, R. P., Gauniyal, H. M. Isoflavonoid C-glycoside from Stephania glabra.. Fitoterapia, 1995.
  2. Shchelchkova, I.I., Il'inskaya, T.N., Kuzovkov, A.D. The alkaloids of Stephania glabra. Chemistry of Natural Compounds, 1965, vol. 1, no. 4, p. 210-212. DOI
  3. Martinez, JA., Bello, A., Rubio, LL., Rodriguez, C., Galan, L., Caudales, E., Alvarez, JL. Calcium antagonist properties of the bisbenzylisoquinoline alkaloid cycleanine. FUNDAMENTAL & CLINICAL PHARMACOLOGY, 1998, vol. 12, no. 2, p. 182-187.
  4. Fang, K'uo-Chin., Fadeeva, I. I., Il'inskaya, T. N. Stephania alkaloids. II. Alkaloids of Stephania glabra. Khimiya prirodnykh soedinenii, 1965, p. 392-394.
  5. Nguyen, Tien Vung., Pham, Thanh Ky., Bui, Kim Lien., Trinh, Van Bao. Evaluation of the mutagenic potential on chromosomes of L-tetrahydropalmatine extracted from rhizoma of Stephania glabra (Roxb.) Miers. Tap chi duoc hoc, 1998, p. 19-21.
  6. CAVA, MP., NOMURA, K., TALAPATR.SK., MITCHELL, MJ., SCHLESSI.RH., BUCK, KT., BEAL, JL., DOUGLAS, B., RAFFAUF, RF., WEISBACH, JA. ALKALOIDS OF STEPHANIA GLABRA . A DIRECT CHEMICAL CORRELATION OF ABSOLUTE CONFIGURATION OF SOME BENZYLTETRAHYDROISOQUINOLINE PROAPORPHINE AND APORPHINE ALKALOIDS . A NEW PROTOBERBERINE ALKALOID . Journal of organic chemistry, 1968, vol. 33, no. 7, p. 2785-&. DOI
  7. Ngo, Van Thu., Nuhn, P. Alkaloids of Stephania glabra. Pharmazie, 1971, p. 504-505.
  8. Semwal, Deepak Kumar., Rawat, Usha. Gindarudine, a novel morphine alkaloid from Stephania glabra. CHINESE CHEMICAL LETTERS, 2009, vol. 20, no. 7, p. 823-826. DOI
  9. Wa, M.T., Beal, J.L., Doskotch, R.W. A study of the quaternary alkaloids of Stephania glabra. Lloydia, 1967, vol. 30, no. 3, p. 245-249.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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