Botanical species · safety record

Stevia rebaudiana

The EFSA Compendium of Botanicals holds 7 constituent measurements and 1 genotoxicity assay for Stevia rebaudiana. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Stevia rebaudiana Bertoni

7Constituent measurements

1Safety records

4Cited sources

31Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 31 licensed products naming Stevia rebaudiana as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Source material stated

Leaf
Leaf extract
Leaf/Leaves
Stevia rebaudiana leaves

What the records describe

Constituents measured

Plant parts

Preparations

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Alkaloids	Leaves	Solvent extraction	—	Phytochemical screening	Resolve DOI
Anthraquinones	Leaves	Solvent extraction	—	Phytochemical screening	Resolve DOI
Cardiac glycosides	Leaves	Solvent extraction	—	Phytochemical screening	Resolve DOI
Proanthocyanidins (condensed tannins)	Leaves	Solvent extraction	≤ 128.7 Milligram/gram	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Proanthocyanidins (condensed tannins)	Leaves	Solvent extraction	≥ 110.5 Milligram/gram	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Saponins	Leaves	Solvent extraction	—	Phytochemical screening	Resolve DOI
Coumarins	Leaves	Solvent extraction	—	Unspecified	No resolvable identifier

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	DNA damage and/or repair	single cell gel/comet assay in mammalian cells for detection of DNA damage	Rat (as animal)	—	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Adisakwattana, Sirichai., Jiphimai, Pariwat., Prutanopajai, Pornsawan., Chanathong, Benjanut., Sapwarobol, Suwimol., Ariyapitipan, Tipayanate. Evaluation of alpha-glucosidase, alpha-amylase and protein glycation inhibitory activities of edible plants. INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION, 2010, vol. 61, no. 3, p. 295-305. DOI
Tadhani, M., Subhash, R. Preliminary studies on Stevia rebaudiana leaves: Proximal composition, mineral analysis and phytochemical screening. Journal of medical sciences, 2006, vol. 6, no. 3, p. 321-326. DOI
Nunes, A. P. M., Ferreira-Machado, S. C., Nunes, R. M., Dantas, F. J. S., De Mattos, J. C. P., Caldeira-de-Araujo, A. Analysis of genotoxic potentiality of stevioside by comet assay. FOOD AND CHEMICAL TOXICOLOGY, 2007, vol. 45, no. 4, p. 662-666. DOI
Komissarenko, N. F., Derkach, A. I., Kovalyov I. P., Bublik, N. P. Diterpene glycosides and phenylpropanoids of leaves of Stevia rebaudiana Bertoni (Asteraceae). Rastitel'nye resursy, 1994, p. 53-64.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature