Botanical species · safety record

Strychnos nux-vomica

The EFSA Compendium of Botanicals holds 10 constituent measurements and 9 adverse-effect records for Strychnos nux-vomica. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Strychnos nux-vomica L.

10Constituent measurements

9Safety records

9Cited sources

27Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 27 licensed products naming Strychnos nux-vomica as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Source material stated

Coarsely powdered seeds
Coarsly powdered seeds
Dried ripe seeds
Dried seed
Dried seed(s)
Grain(s)
Seed(s)
Seeds coarsely powdered

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Brucine	Seed	Solvent extraction	0.16 Percent	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	Resolve DOI
Strychnine	Seed	Solvent extraction	0.175 Percent	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	Resolve DOI
Alpha-colubrine	Seed	Solvent extraction	—	HPLC-MS/MS	No resolvable identifier
Beta-colubrine	Seed	Solvent extraction	—	HPLC-MS/MS	No resolvable identifier
Brucine	Seed	Solvent extraction	—	HPLC-MS/MS	No resolvable identifier
Icajine	Seed	Solvent extraction	—	HPLC-MS/MS	No resolvable identifier
Indole alkaloids	Seed	Solvent extraction	—	HPLC-MS/MS	No resolvable identifier
Novacine	Seed	Solvent extraction	—	HPLC-MS/MS	No resolvable identifier
Strychnine	Seed	Solvent extraction	—	HPLC-MS/MS	No resolvable identifier
Vomicine	Seed	Solvent extraction	—	HPLC-MS/MS	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Systemic	Cardiovascular / haematological	Unspecified	—	Human (as organism)	Case report	Resolve DOI
Nephrotoxicity	Urogenital: kidneys	Bark	Solvent extraction	Human (as organism)	Case report	No resolvable identifier
Neurotoxicity	Urogenital: kidneys	Aerial part of plants	—	Human (as organism)	Case report	No resolvable identifier
Neurotoxicity	Neurologic	Bark	Solvent extraction	Human (as organism)	Case report	No resolvable identifier
Neurotoxicity	Urogenital: kidneys	Bark	Solvent extraction	Human (as organism)	Case report	No resolvable identifier
Neurotoxicity	Urogenital: kidneys	Seed	Solvent extraction	Human (as organism)	Case report	No resolvable identifier
Not reported	—	Seed	—	House mouse (as animal)	Acute toxicity	No resolvable identifier
Systemic	Muscle, skeletal	Leaves	Raw, no heat treatment	Human (as organism)	Case report	No resolvable identifier
Systemic	Neurologic	Bark	Solvent extraction	Human (as organism)	Case report	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Li, Shujuan., Zhang, Meiyu., Hou, Pengyi., Zhang, Ruowen., Hou, Chenzhi., Bi, Kaishun., Chen, Xiaohui. Identification of the toxic components in Semen Strychni and their metabolites in rat serum by high performance liquid chromatography coupled with a Q Exactive high-resolution benchtop quadrupole Orbitrap mass spectrometer. Rsc advances, 2015, vol. 5, no. 95, p. 77689-77698.
Anwar, Noman., Khan, Masood Shah., Kabir, Hifzul., Ahmad, Sayeed. Effect of detoxification (tadbeer) in content of toxic metabolites of Strychnos nux-vomica: A Unani approach for its use in human . Journal of pharmacy and bioallied sciences, 2015, vol. 7, no. 4, p. 314-316. DOI
Naik, B Sadananda., Chakrapani, M. A rare case of brucine poisoning complicated by rhabdomyolysis and acute renal failure. . The malaysian journal of pathology, 2009, vol. 31, no. 1, p. 67-9.
Kidiyoor, Y., Rai, S., Bakkannavar, S.M., Nayak, V.C., James, R.I., Saravu, K. Rhabdomyolysis and strychnine poisoning: A case report. Research journal of pharmaceutical, biological and chemical sciences, 2016, vol. 7, no. 6, p. 45-47.
Dasari, Sowjanya., Naha, Kushal. A rare case of strychnine poisoning by consumption of Strychnos nux-vomica leaves . Asian pacific journal of tropical biomedicine, 2011, vol. 1, no. 2, p. S303-S304.
Karthik Rao, N., Nayak, V.C., James, R.I., Patil, N., Rao, R., Jaunky, C., Ahmed, T. Survival after strychnine poisoning: A case report. Research journal of pharmaceutical, biological and chemical sciences, 2016, vol. 7, no. 1, p. 1769-1771.
Gopalkrishna, S.V., Lakshminarsu, M., Ramachandra Setty, S. Effect of purification (sodhana) on the acute toxicity of seeds of nux-vomica. Pharmacologyonline, 2009, vol. 3, p. 1015-1024.
Gicquel, T., Lepage, S., Baert, A., Morel, I. Case report: Concerning strychnine poisoning by Nux vomica mother tincture Cas clinique: � propos d'une intoxication � la strychnine par la teinture m�re Nux vomica . Annales de toxicologie analytique, 2012, vol. 24, no. 1, p. 33-37. DOI
Achappa, Basavaprabhu., Madi, Deepak., Babu, Y P Raghavendra., Mahalingam, Soundarya. Rituals can kill - A fatal case of brucine poisoning.. The australasian medical journal, 2012, vol. 5, no. 8, p. 421-3.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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