Botanical species · safety record

Tabernanthe iboga

The EFSA Compendium of Botanicals holds 9 constituent measurements and 6 adverse-effect records for Tabernanthe iboga. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Tabernanthe iboga Baill.

9Constituent measurements

6Safety records

4Cited sources

0Licensed products (Canada)

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Ibogaine	Roots and other underground parts	Powder	7.2 Percent	GC-MS/MS	Resolve DOI
Ibogaine	Roots and other underground parts	Solvent extraction	≥ 1.8 Milligram/gram	LC-MS	Resolve DOI
Ibogaine	Roots and other underground parts	Solvent extraction	≤ 5.93 Milligram/gram	LC-MS	Resolve DOI
Indole alkaloids	Roots and other underground parts	Solvent extraction	11.9 Percent	LC-MS	Resolve DOI
Indole alkaloids	Roots and other underground parts	Solvent extraction	—	LC-MS	Resolve DOI
Indole alkaloids	Roots and other underground parts	Powder	0.6 Percent	GC-MS/MS	Resolve DOI
Indole alkaloids	Roots and other underground parts	Solvent extraction	21.5 Percent	LC-MS	Resolve DOI
Indole alkaloids	Roots and other underground parts	Solvent extraction	—	LC-MS	Resolve DOI
Voacangine	Roots and other underground parts	Solvent extraction	30.5 Percent	LC-MS	Resolve DOI

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Pulmonary and cardiac	Heart	Roots and other underground parts	—	Human (as organism)	Case report	Resolve DOI
Pulmonary and cardiac	Heart	Roots and other underground parts	—	Human (as organism)	Case report	Resolve DOI
Pulmonary and cardiac	Heart	Roots and other underground parts	—	Human (as organism)	Case report	Resolve DOI
Pulmonary and cardiac	Heart	Roots and other underground parts	Powder	Human (as organism)	Case report	Resolve DOI
Pulmonary and cardiac	Heart	Roots and other underground parts	—	Human (as organism)	Case report	Resolve DOI
Pulmonary and cardiac	Heart	Roots and other underground parts	Powder	Human (as organism)	Case report	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Kontrimaviciute, V., Mathieu, O., Balas, L., Escale, R., Blayac, Jean Pierre., Bressolle, F. M. M. Ibogaine and noribogaine: Structural analysis and stability studies. Use of LC-MS to determine alkaloid contents of the root bark of Tabernanthe iboga . Journal of liquid chromatography & related technologies, 2007, vol. 30, no. 5-8, p. 1077-1092. DOI
Mazoyer, C., Carlier, J., Peoc'H, M., Lemeur, C., Boucher, A., B�valot, F., Guitton, J., Gaillard, Y. Fatal intoxication after taking iboga: GC-MS/MS determination of ibogaine and ibogamine in iboga roots and post-mortem material Intoxication mortelle � l' iboga: Quantification de l'iboga�ne et de l'ibogamine dans des racines d' iboga et dans des pr�l� vements post-mortem par CPG-SM/SM . Annales de toxicologie analytique, 2012, vol. 24, no. 1, p. 39-47. DOI
Cheze, Marjorie., Lenoan, Aurelie., Deveaux, Marc., Pepin, Gilbert. Determination of ibogaine and noribogaine in biological fluids and hair by LC-MS/MS after Tabernanthe iboga abuse Iboga alkaloids distribution in a drowning death case . Forensic science international, 2008, vol. 176, no. 1, p. 58-66. DOI
Kontrimaviciute, Violeta., Mathieu, Olivier., Mathieu-Daude, Jean-Claude., Vainauskas, Paulius., Casper, Thierry., Baccino, Eric., Bressolle, Francoise M. M. Distribution of ibogaine and noribogaine in a man following a poisoning involving root bark of the Tabernanthe iboga shrub . Journal of analytical toxicology, 2006, vol. 30, no. 7, p. 434-440.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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