Botanical species · safety record

Taxus baccata

The EFSA Compendium of Botanicals holds 6 constituent measurements and 26 adverse-effect records for Taxus baccata. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Taxus baccata L.

6Constituent measurements

26Safety records

13Cited sources

9Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 9 licensed products naming Taxus baccata as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Source material stated

Twigs with berries

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Taxine	Leaves	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Taxine	Leaves	—	—	HPLC-MS/MS	Resolve DOI
Taxine	Leaves	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Cyanogenic glycosides	Seed	—	—	Mass Spectroscopy and hyphenated methods without chromatography	No resolvable identifier
Tannic acid	Bark	Solvent extraction	—	Unspecified	No resolvable identifier
Taxine	Seed	—	—	Mass Spectroscopy and hyphenated methods without chromatography	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Digestive	Digestive	Leaves	Solvent extraction	Human (as organism)	Case report	Resolve DOI
Neurotoxicity	Neurologic	Leaves	—	Human (as organism)	Case report	Resolve DOI
Not reported	—	Leaves	—	Mammals (as animal)	Case report	Resolve DOI
Other toxicities	—	Leaves	—	Human (as organism)	Case report	Resolve DOI
Other toxicities	—	Leaves	—	Human (as organism)	Case report	Resolve DOI
Pulmonary and cardiac	—	Leaves	—	Sheep (as animal)	Not reported	Resolve DOI
Pulmonary and cardiac	—	Leaves	—	Dog (as animal)	Not reported	Resolve DOI
Pulmonary and cardiac	—	Leaves	—	Horse (as animal)	Not reported	Resolve DOI
Pulmonary and cardiac	—	Leaves	—	Horse (as animal)	Not reported	Resolve DOI
Pulmonary and cardiac	—	Leaves	—	Human (as organism)	Not reported	Resolve DOI
Pulmonary and cardiac	—	Leaves	—	Human (as organism)	Not reported	Resolve DOI
Pulmonary and cardiac	—	Leaves	—	Pig (as animal)	Not reported	Resolve DOI
Pulmonary and cardiac	—	Leaves	—	Rabbit (as animal)	Not reported	Resolve DOI
Pulmonary and cardiac	—	Leaves	—	Cattle (as animal)	Not reported	Resolve DOI
Pulmonary and cardiac	—	Leaves	—	Bird (as animal)	Not reported	Resolve DOI
Pulmonary and cardiac	Respiratory	Leaves	—	Human (as organism)	Case report	Resolve DOI
Pulmonary and cardiac	Cardiovascular / haematological	Leaves	—	Human (as organism)	Case report	Resolve DOI
Pulmonary and cardiac	Respiratory	Leaves	—	Human (as organism)	Case report	Resolve DOI
Pulmonary and cardiac	Heart	Leaves	—	Horse (as animal)	Case report	Resolve DOI
Pulmonary and cardiac	Heart	Leaves	—	Horse (as animal)	Case report	Resolve DOI
Pulmonary and cardiac	Cardiovascular / haematological	Leaves	Solvent extraction	Human (as organism)	Case report	Resolve DOI
Pulmonary and cardiac	—	Leaves	—	Goat (as animal)	Not reported	Resolve DOI
Not stated	Cardiovascular / haematological	Leaves	—	—	Case report	Resolve DOI
Other toxicities	—	Seed	—	Mammals (as animal)	Case report	No resolvable identifier
Pulmonary and cardiac	Cardiovascular / haematological	Leaves	—	Mammals (as animal)	Case report	No resolvable identifier
Pulmonary and cardiac	Cardiovascular / haematological	Leaves	—	Human (as organism)	Case report	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Wilson, CR., Sauer, JM., Hooser, SB. Taxines: a review of the mechanism and toxicity of yew (Taxus spp.) alkaloids . Toxicon, 2001, vol. 39, no. 2-3, p. 175-185. DOI
Fuchs, Joan., Rauber-Luethy, Christine., Kupferschmidt, Hugo., Kupper, Jacqueline., Kullak-Ublick, Gerd-Achim., Ceschi, Alessandro. Acute plant poisoning: Analysis of clinical features and circumstances of exposure . Clinical toxicology, 2011, vol. 49, no. 7, p. 671-680. DOI
Kominkova, Marketa., Stanisavljevic, Maja., Zitka, Ondrej., Mazanek, Stanislav., Sedlackova, Jana., Bandouchova, Hana., Pikula, Jiri., Beklova, Miroslava., Kizek, Rene. Yew poisoning of olive baboons (Papio anubis) in captivity: laboratory diagnosis . Neuroendocrinology letters, 2013, vol. 34, p. 130-133.
Gaunitz, F., Sch�renkamp, J., Rostamzadeh, A., Konkol, C., Thevis, M., Rothschild, M.A., Mercer-Chalmers-Bender, K. Analysis of taxine B/isotaxine B in a plasma specimen by LC-MS/MS in a case of fatal poisoning: concealed suicide by ingestion of yew (Taxus L.) leaves of a patient with a long-term history of borderline personality disorder. Forensic toxicology, 2017, vol. 35, no. 2, p. 421-427. DOI
Caloni, F., Cortinovis, C. Plants poisonous to horses in Europe. Equine veterinary education, 2015, vol. 27, no. 5, p. 269-274. DOI
Valis, M., Koc�, J., Tucek, D., Lutonsk�, T., Kopov�, J., Barton, P., Vysata, O., Kraj�ckov�, D., Kor�becn�, J., Masopust, J., Klzo, L. Common yew intoxication: A case report. Journal of medical case reports, 2014, vol. 8, no. 1. DOI
Andersen, Karina Barbara., Skaanild, Mette Tingleff., Bertelsen, Mads Frost., Brimer, Leon. Yew intoxication in brown bears; a novel approach to diagnosis. European journal of wildlife research, 2010, vol. 56, no. 6, p. 915-921. DOI
MUSSHOFF, F., JACOB, B., FOWINKEL, C., DALDRUP, T. SUICIDAL YEW LEAVE INGESTION - PHLOROGLUCINDIMETHYLETHER (3,5-DIMETHOXYPHENOL) AS A MARKER FOR POISONING FROM TAXUS-BACCATA . International journal of legal medicine, 1993, vol. 106, no. 1, p. 45-50. DOI
GIBSON, DM., GALLO, LG., KRASNOFF, SB., KETCHUM, REB. INCREASED EFFICACY OF BACILLUS-THURINGIENSIS SUBSP KURSTAKI IN COMBINATION WITH TANNIC-ACID . Journal of economic entomology, 1995, vol. 88, no. 2, p. 270-277.
Tranca, Sebastian., Petrisor, Cristina Laura. A fatal case of Taxus poisoning.. Clujul medical (1957), 2013, vol. 86, no. 3, p. 279-81.
Reijnen, Guido., Bethlehem, Corine., van Remmen, Jacquo M B L., Smit, Hans J M., van Luin, Matthijs., Reijnders, Udo J L. Post-mortem findings in 22 fatal Taxus baccata intoxications and a possible solution to its detection. . Journal of forensic and legal medicine, 2017, vol. 52, p. 56-61. DOI
Panzeri, Claudia., Bacis, Giuseppe., Ferri, Francesco., Rinaldi, Gabriele., Persico, Andrea., Uberti, Francesca., Restani, Patrizia. Extracorporeal life support in a severe Taxus baccata poisoning. Clinical toxicology, 2010, vol. 48, no. 5, p. 463-465. DOI
Lacasse, Claude., Gamble, Kathryn C., Poppenga, Robert H., Farina, Lisa L., Landolfi, Jennifer., Terio, Karen. Taxus sp intoxication in three Francois' langurs (Trachypithecus francoisi) . Journal of veterinary diagnostic investigation, 2007, vol. 19, no. 2, p. 221-224.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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