Botanical species · safety record

Tetradium ruticarpum

The EFSA Compendium of Botanicals holds 32 constituent measurements and 3 adverse-effect records for Tetradium ruticarpum. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Tetradium ruticarpum (A. Juss.) T.G. Hartley

32Constituent measurements

3Safety records

8Cited sources

132Licensed products (Canada)

Also recorded as

Evodia ruticarpa (A.Juss.) Hook.f. & Thomson

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 132 licensed products naming Tetradium ruticarpum as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Dry
Extract Type TBA

Source material stated

Dried and nearly ripe fruit (processed)
Fruit
Fruit extract

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Carboline alkaloids	Fruit unspecified	Solvent extraction	—	HPLC-MS/MS	Resolve DOI
Dehydroevodiamine	Fruit unspecified	Solvent extraction	—	HPLC-DAD	Resolve DOI
Dehydroevodiamine	Fruit unspecified	Solvent extraction	≤ 0.2943 Percent	UHPLC-MS-MS	Resolve DOI
Dehydroevodiamine	Fruit unspecified	Solvent extraction	≥ 0.002 Percent	UHPLC-MS-MS	Resolve DOI
Evodiamine	Fruit unspecified	Solvent extraction	—	LC-HR-MS	Resolve DOI
Evodiamine	Fruit unspecified	Solvent extraction	≥ 4e-04 Percent	UHPLC-MS-MS	Resolve DOI
Evodiamine	Fruit unspecified	Solvent extraction	≤ 0.1137 Percent	UHPLC-MS-MS	Resolve DOI
Evodiamine	Fruit unspecified	Solvent extraction	≥ 0.07 Milligram/gram	HPLC with standard detection methods	Resolve DOI
Evodiamine	Fruit unspecified	Solvent extraction	≤ 9.16 Milligram/gram	HPLC with standard detection methods	Resolve DOI
Limonin	Fruit unspecified	Solvent extraction	≥ 0.0154 Percent	UHPLC-MS-MS	Resolve DOI
Limonin	Fruit unspecified	Solvent extraction	≤ 1.934 Percent	UHPLC-MS-MS	Resolve DOI
Limonin	Fruit unspecified	Solvent extraction	—	HPLC-MS/MS	Resolve DOI
Quinoline alkaloids	Fruit unspecified	Solvent extraction	—	HPLC-MS/MS	Resolve DOI
Quinolones	Fruit unspecified	Solvent extraction	—	LC-HR-MS	Resolve DOI
Quinolones	Fruit unspecified	Solvent extraction	—	HPLC-MS/MS	Resolve DOI
Rutaecarpine	—	Solvent extraction	≥ 0.03 Milligram/gram	—	Resolve DOI
Rutaecarpine	Fruit unspecified	Solvent extraction	≤ 11.04 Milligram/gram	HPLC with standard detection methods	Resolve DOI
Rutaecarpine	Fruit unspecified	Solvent extraction	≥ 1.76 Milligram/gram	HPLC with standard detection methods	Resolve DOI
Rutaecarpine	Fruit unspecified	Solvent extraction	≤ 0.6025 Percent	UHPLC-MS-MS	Resolve DOI
Rutaecarpine	Fruit unspecified	Solvent extraction	≥ 0.0176 Percent	UHPLC-MS-MS	Resolve DOI
Rutaecarpine	Fruit unspecified	Solvent extraction	—	LC-HR-MS	Resolve DOI
Rutaecarpine	—	Solvent extraction	≤ 7.6 Milligram/gram	—	Resolve DOI
Synephrine	Fruit unspecified	Solvent extraction	≥ 0.52 Milligram/gram	HPLC with standard detection methods	Resolve DOI
Synephrine	Fruit unspecified	Solvent extraction	≤ 2.42 Milligram/gram	HPLC with standard detection methods	Resolve DOI
Evodiamine	Fruit unspecified	Solvent extraction	≥ 0.393 Percent	HPLC-DAD	No resolvable identifier
Evodiamine	Fruit unspecified	Solvent extraction	≤ 2.466 Percent	HPLC-DAD	No resolvable identifier
Limonin	Fruit unspecified	Solvent extraction	≥ 0.333 Percent	HPLC-DAD	No resolvable identifier
Limonin	Fruit unspecified	Solvent extraction	≤ 0.815 Percent	HPLC-DAD	No resolvable identifier
Limonoids	Fruit unspecified	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Limonoids	Fruit unspecified	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Rutaecarpine	Fruit unspecified	Solvent extraction	≤ 1.393 Percent	HPLC-DAD	No resolvable identifier
Rutaecarpine	Fruit unspecified	Solvent extraction	≥ 0.151 Percent	HPLC-DAD	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Hepatotoxicity	Liver	Fruit unspecified	Solvent extraction	House mouse (as animal)	Short-term toxicity	Resolve DOI
Systemic	—	—	—	Rat (as animal)	Other	Resolve DOI
Systemic	—	—	—	Rat (as animal)	Other	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Pellati, F., Benvenuti, S., Yoshizaki, F., Melegari, M. Development and validation of HPLC methods for the analysis of phenethylamine and indoloquinazoline alkaloids in Evodia species . Journal of separation science, 2006, vol. 29, no. 5, p. 641-649. DOI
Ueng, YF., Tsai, TH., Don, MJ., Chen, RM., Chen, TL. Alteration of the pharmacokinetics of theophylline by rutaecarpine, an alkaloid of the medicinal herb Evodia rutaecarpa, in rats . Journal of pharmacy and pharmacology, 2005, vol. 57, no. 2, p. 227-232. DOI
Zhao, Yang., Zhao, Yunling., Zhou, Xin., Gong, Xiaojian. Development and validation of an UPLC-ESI-MS/MS method for determination of dehydroevodiamine, limonin, evodiamine, and rutaecarpine in Evodiae Fructus . Pharmacognosy magazine, 2014, vol. 10, no. 39, p. 374-383. DOI
Yang, X. -W., Zhang, H., Li, M., Du, L. -J., Yang, Z., Xiao, S. -Y. Studies on the alkaloid constituents of Evodia rutaecarpa (Juss) Benth var. bodinaieri (Dode) Huang and their acute toxicity in mice . Journal of asian natural products research, 2006, vol. 8, no. 8, p. 697-703. DOI
Zhang, Hongmei., Wang, Changhong., Cheng, Xuemei., Wang, Zhengtao., Yue, Jianmin. Simultaneous determination of limonin, evodiamine and rutaecarpine in Fructus Evodiae by high-performance liquid chromatography. Asian journal of traditional medicines, 2008, vol. 3, no. 5, p. 163-171.
Schramm, Anja., Hamburger, Matthias. Gram-scale purification of dehydroevodiamine from Evodia rutaecarpa fruits, and a procedure for selective removal of quaternary indoloquinazoline alkaloids from Evodia extracts . Fitoterapia, 2014, vol. 94, p. 127-133. DOI
Li, Wenlan., Sun, Xiangming., Liu, Bingmei., Zhang, Lihui., Fan, Ziquan., Ji, Yubin. Screening and identification of hepatotoxic component in Evodia rutaecarpa based on spectrum-effect relationship and UPLC-Q-TOFMS . Biomedical chromatography, 2016, vol. 30, no. 12, p. 1975-1983. DOI
Yang, Xiu-Wei., Teng, Jie. Chemical constituents of the unripe fruits of Evodia rutaecarpa. Journal of chinese pharmaceutical sciences, 2007, vol. 16, no. 1, p. 20-23.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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