Botanical species · safety record

Teucrium chamaedrys

The EFSA Compendium of Botanicals holds 16 constituent measurements and 8 adverse-effect records for Teucrium chamaedrys. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Teucrium chamaedrys L.

16Constituent measurements

8Safety records

12Cited sources

0Licensed products (Canada)

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Clerodane-type diterpenes	Aerial part of plants	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Clerodane-type diterpenes	Leaves	Solvent extraction	—	Mass Spectroscopy and hyphenated methods without chromatography	Resolve DOI
Clerodane-type diterpenes	Aerial part of plants	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Furan derivatives	Aerial part of plants	Solvent extraction	122 ppm	LC-MS	Resolve DOI
Furan derivatives	Aerial part of plants	Solvent extraction	144 ppm	LC-MS	Resolve DOI
Furan derivatives	Aerial part of plants	Solvent extraction	711 ppm	LC-MS	Resolve DOI
Furan derivatives	Aerial part of plants	Solvent extraction	87 ppm	LC-MS	Resolve DOI
Furan derivatives	Aerial part of plants	Solvent extraction	91 ppm	LC-MS	Resolve DOI
Phenylpropanoids	Aerial part of plants	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Saponins	Unspecified	—	—	Unspecified	Resolve DOI
Teucrin a	Aerial part of plants	Solvent extraction	≥ 1.09 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Teucrin a	Aerial part of plants	Solvent extraction	≥ 0.45 Percent	LC-MS	Resolve DOI
Teucrin a	Aerial part of plants	Solvent extraction	≤ 2.3 Percent	LC-MS	Resolve DOI
Teucrin a	Aerial part of plants	Solvent extraction	2251 ppm	LC-MS	Resolve DOI
Podophyllotoxin	Aerial part of plants	Solvent extraction	0.14 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Teucrin a	Aerial part of plants	—	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Hepatotoxicity	Liver	Unspecified	—	Human (as organism)	Other	Resolve DOI
Hepatotoxicity	Liver	Aerial part of plants	Solvent extraction	House mouse (as animal)	Acute toxicity	Resolve DOI
Hepatotoxicity	Liver	Aerial part of plants	—	Rat (as animal)	Subchronic	Resolve DOI
Hepatotoxicity	Liver	Unspecified	—	Human (as organism)	Case report	Resolve DOI
Hepatotoxicity	Liver	Unspecified	—	Human (as organism)	Case report	Resolve DOI
Hepatotoxicity	—	Aerial part of plants	—	Human (as organism)	Case report	Resolve DOI
Hepatotoxicity	Liver	Unspecified	—	Human (as organism)	Other	No resolvable identifier
Hepatotoxicity	Liver	Aerial part of plants	—	Human (as organism)	Case report	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

De Vincenzi, M., Maialetti, F., Silano, M. Constituents of aromatic plants: teucrin A. Fitoterapia, 2003, vol. 74, no. 7-8, p. 746-749. DOI
Furbee, RB., Barlotta, KS., Allen, MK., Holstege, CP. Hepatotoxicity associated with herbal products. Clinics in laboratory medicine, 2006, vol. 26, no. 1, p. 227-+. DOI
Haslan, Haszianaliza., Suhaimi, Farihah Haji., Das, Srijit. Herbal Supplements and Hepatotoxicity: A Short Review. Natural product communications, 2015, vol. 10, no. 10, p. 1779-1784.
Ravichandiran, V., Satish, P.V. A review on hepatotoxicity of phytomedicines. International journal of pharmacognosy and phytochemical research, 2013, vol. 5, no. 3, p. 186-191.
Stedman, C. Herbal hepatotoxicity. Seminars in liver disease, 2002, vol. 22, no. 2, p. 195-206. DOI
Rader, Jeanne I., Delmonte, Pierluigi., Trucksess, Mary W. Recent studies on selected botanical dietary supplement ingredients. Analytical and bioanalytical chemistry, 2007, vol. 389, no. 1, p. 27-35. DOI
Konuklugil, Belma. Investigation of podophyllotoxin in some plants in Lamiaceae using HPLC. Ankara universitesi eczacilik fakultesi dergisi, 1996, vol. 25, no. 1, p. 23-27.
KOUZI, SA., MCMURTRY, RJ., NELSON, SD. HEPATOTOXICITY OF GERMANDER (TEUCRIUM-CHAMAEDRYS L) AND ONE OF ITS CONSTITUENT NEOCLERODANE DITERPENES TEUCRIN-A IN THE MOUSE . Chemical research in toxicology, 1994, vol. 7, no. 6, p. 850-856. DOI
Lin, Long-Ze., Harnly, James M., Upton, Roy. Comparison of the Phenolic Component Profiles of Skullcap (Scutellaria lateriflora) and Germander (Teucrium canadense and T. chamaedrys), a Potentially Hepatotoxic Adulterant . Phytochemical analysis, 2009, vol. 20, no. 4, p. 298-306. DOI
Bosisio, E., Giavarini, F., Dell'Agli, M., Galli, G., Galli, CL. Analysis by high-performance liquid chromatography of teucrin A in beverages flavoured with an extract of Teucrium chamaedrys L. . Food additives and contaminants, 2004, vol. 21, no. 5, p. 407-414. DOI
Ricci, Andreina., Piccolella, Simona., Fiorentino, Antonio., Pepi, Federico., D'Abrosca, Brigida., Monaco, Pietro. A tandem mass spectrometric investigation of the low-energy collision-activated fragmentation of neo-clerodane diterpenes . Rapid communications in mass spectrometry, 2010, vol. 24, no. 11, p. 1543-1556. DOI
Lekehal, M., Pessayre, D., Lereau, JM., Moulis, C., Fouraste, I., Fau, D. Hepatotoxicity of the herbal medicine germander: Metabolic activation of its furano diterpenoids by cytochrome P450 3A depletes cytoskeleton-associated protein thiols and forms plasma membrane blebs in rat hepatocytes . Hepatology, 1996, vol. 24, no. 1, p. 212-218. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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