Botanical species · safety record

Teucrium chamaedrys

The EFSA Compendium of Botanicals holds 16 constituent measurements and 8 adverse-effect records for Teucrium chamaedrys. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Teucrium chamaedrys L.

16Constituent measurements
8Safety records
12Cited sources
0Licensed products (Canada)

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

  • Furan derivatives5
  • Teucrin a5
  • Clerodane-type diterpenes3
  • Phenylpropanoids1
  • Podophyllotoxin1
  • Saponins1

Plant parts

  • Aerial part of plants18
  • Unspecified5
  • Leaves1

Preparations

  • Solvent extraction15

Effect types

  • Hepatotoxicity8

Target tissues

  • Liver7

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

SubstancePlant partPreparationConcentrationAnalytical methodSource
Clerodane-type diterpenesLeavesSolvent extractionMass Spectroscopy and hyphenated methods without chromatographyResolve DOI
Clerodane-type diterpenesAerial part of plantsSolvent extractionHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)Resolve DOI
Clerodane-type diterpenesAerial part of plantsSolvent extractionStandard Chromatographic tests (paper- thin layer- and column chromatography)Resolve DOI
Furan derivativesAerial part of plantsSolvent extraction122 ppmLC-MSResolve DOI
Furan derivativesAerial part of plantsSolvent extraction144 ppmLC-MSResolve DOI
Furan derivativesAerial part of plantsSolvent extraction91 ppmLC-MSResolve DOI
Furan derivativesAerial part of plantsSolvent extraction87 ppmLC-MSResolve DOI
Furan derivativesAerial part of plantsSolvent extraction711 ppmLC-MSResolve DOI
PhenylpropanoidsAerial part of plantsSolvent extractionHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)Resolve DOI
SaponinsUnspecifiedUnspecifiedResolve DOI
Teucrin aAerial part of plantsSolvent extraction≤ 2.3 PercentLC-MSResolve DOI
Teucrin aAerial part of plantsSolvent extraction≥ 0.45 PercentLC-MSResolve DOI
Teucrin aAerial part of plantsSolvent extraction2251 ppmLC-MSResolve DOI
Teucrin aAerial part of plantsSolvent extraction≥ 1.09 PercentHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)Resolve DOI
PodophyllotoxinAerial part of plantsSolvent extraction0.14 PercentHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)No resolvable identifier
Teucrin aAerial part of plantsHigh Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

EffectTarget tissuePlant partPreparationTest organismTest typeSource
HepatotoxicityLiverAerial part of plantsRat (as animal)SubchronicResolve DOI
HepatotoxicityLiverUnspecifiedHuman (as organism)Case reportResolve DOI
HepatotoxicityLiverUnspecifiedHuman (as organism)Case reportResolve DOI
HepatotoxicityLiverUnspecifiedHuman (as organism)OtherResolve DOI
HepatotoxicityAerial part of plantsHuman (as organism)Case reportResolve DOI
HepatotoxicityLiverAerial part of plantsSolvent extractionHouse mouse (as animal)Acute toxicityResolve DOI
HepatotoxicityLiverAerial part of plantsHuman (as organism)Case reportNo resolvable identifier
HepatotoxicityLiverUnspecifiedHuman (as organism)OtherNo resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

  1. Bosisio, E., Giavarini, F., Dell'Agli, M., Galli, G., Galli, CL. Analysis by high-performance liquid chromatography of teucrin A in beverages flavoured with an extract of Teucrium chamaedrys L. . Food additives and contaminants, 2004, vol. 21, no. 5, p. 407-414. DOI
  2. Ravichandiran, V., Satish, P.V. A review on hepatotoxicity of phytomedicines. International journal of pharmacognosy and phytochemical research, 2013, vol. 5, no. 3, p. 186-191.
  3. De Vincenzi, M., Maialetti, F., Silano, M. Constituents of aromatic plants: teucrin A. Fitoterapia, 2003, vol. 74, no. 7-8, p. 746-749. DOI
  4. Furbee, RB., Barlotta, KS., Allen, MK., Holstege, CP. Hepatotoxicity associated with herbal products. Clinics in laboratory medicine, 2006, vol. 26, no. 1, p. 227-+. DOI
  5. Stedman, C. Herbal hepatotoxicity. Seminars in liver disease, 2002, vol. 22, no. 2, p. 195-206. DOI
  6. Haslan, Haszianaliza., Suhaimi, Farihah Haji., Das, Srijit. Herbal Supplements and Hepatotoxicity: A Short Review. Natural product communications, 2015, vol. 10, no. 10, p. 1779-1784.
  7. Ricci, Andreina., Piccolella, Simona., Fiorentino, Antonio., Pepi, Federico., D'Abrosca, Brigida., Monaco, Pietro. A tandem mass spectrometric investigation of the low-energy collision-activated fragmentation of neo-clerodane diterpenes . Rapid communications in mass spectrometry, 2010, vol. 24, no. 11, p. 1543-1556. DOI
  8. Rader, Jeanne I., Delmonte, Pierluigi., Trucksess, Mary W. Recent studies on selected botanical dietary supplement ingredients. Analytical and bioanalytical chemistry, 2007, vol. 389, no. 1, p. 27-35. DOI
  9. Lekehal, M., Pessayre, D., Lereau, JM., Moulis, C., Fouraste, I., Fau, D. Hepatotoxicity of the herbal medicine germander: Metabolic activation of its furano diterpenoids by cytochrome P450 3A depletes cytoskeleton-associated protein thiols and forms plasma membrane blebs in rat hepatocytes . Hepatology, 1996, vol. 24, no. 1, p. 212-218. DOI
  10. Lin, Long-Ze., Harnly, James M., Upton, Roy. Comparison of the Phenolic Component Profiles of Skullcap (Scutellaria lateriflora) and Germander (Teucrium canadense and T. chamaedrys), a Potentially Hepatotoxic Adulterant . Phytochemical analysis, 2009, vol. 20, no. 4, p. 298-306. DOI
  11. KOUZI, SA., MCMURTRY, RJ., NELSON, SD. HEPATOTOXICITY OF GERMANDER (TEUCRIUM-CHAMAEDRYS L) AND ONE OF ITS CONSTITUENT NEOCLERODANE DITERPENES TEUCRIN-A IN THE MOUSE . Chemical research in toxicology, 1994, vol. 7, no. 6, p. 850-856. DOI
  12. Konuklugil, Belma. Investigation of podophyllotoxin in some plants in Lamiaceae using HPLC. Ankara universitesi eczacilik fakultesi dergisi, 1996, vol. 25, no. 1, p. 23-27.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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