Botanical species · safety record
Teucrium chamaedrys
The EFSA Compendium of Botanicals holds 16 constituent measurements and 8 adverse-effect records for Teucrium chamaedrys. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.
Accepted name in source: Teucrium chamaedrys L.
Regulatory presence
No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.
What the records describe
Constituents measured
- Furan derivatives5
- Teucrin a5
- Clerodane-type diterpenes3
- Phenylpropanoids1
- Podophyllotoxin1
- Saponins1
Plant parts
- Aerial part of plants18
- Unspecified5
- Leaves1
Preparations
- Solvent extraction15
Effect types
- Hepatotoxicity8
Target tissues
- Liver7
Recorded constituents
What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.
| Substance | Plant part | Preparation | Concentration | Analytical method | Source |
|---|---|---|---|---|---|
| Clerodane-type diterpenes | Leaves | Solvent extraction | — | Mass Spectroscopy and hyphenated methods without chromatography | Resolve DOI |
| Clerodane-type diterpenes | Aerial part of plants | Solvent extraction | — | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | Resolve DOI |
| Clerodane-type diterpenes | Aerial part of plants | Solvent extraction | — | Standard Chromatographic tests (paper- thin layer- and column chromatography) | Resolve DOI |
| Furan derivatives | Aerial part of plants | Solvent extraction | 122 ppm | LC-MS | Resolve DOI |
| Furan derivatives | Aerial part of plants | Solvent extraction | 144 ppm | LC-MS | Resolve DOI |
| Furan derivatives | Aerial part of plants | Solvent extraction | 91 ppm | LC-MS | Resolve DOI |
| Furan derivatives | Aerial part of plants | Solvent extraction | 87 ppm | LC-MS | Resolve DOI |
| Furan derivatives | Aerial part of plants | Solvent extraction | 711 ppm | LC-MS | Resolve DOI |
| Phenylpropanoids | Aerial part of plants | Solvent extraction | — | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | Resolve DOI |
| Saponins | Unspecified | — | — | Unspecified | Resolve DOI |
| Teucrin a | Aerial part of plants | Solvent extraction | ≤ 2.3 Percent | LC-MS | Resolve DOI |
| Teucrin a | Aerial part of plants | Solvent extraction | ≥ 0.45 Percent | LC-MS | Resolve DOI |
| Teucrin a | Aerial part of plants | Solvent extraction | 2251 ppm | LC-MS | Resolve DOI |
| Teucrin a | Aerial part of plants | Solvent extraction | ≥ 1.09 Percent | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | Resolve DOI |
| Podophyllotoxin | Aerial part of plants | Solvent extraction | 0.14 Percent | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | No resolvable identifier |
| Teucrin a | Aerial part of plants | — | — | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | No resolvable identifier |
Recorded adverse effects
Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.
| Effect | Target tissue | Plant part | Preparation | Test organism | Test type | Source |
|---|---|---|---|---|---|---|
| Hepatotoxicity | Liver | Aerial part of plants | — | Rat (as animal) | Subchronic | Resolve DOI |
| Hepatotoxicity | Liver | Unspecified | — | Human (as organism) | Case report | Resolve DOI |
| Hepatotoxicity | Liver | Unspecified | — | Human (as organism) | Case report | Resolve DOI |
| Hepatotoxicity | Liver | Unspecified | — | Human (as organism) | Other | Resolve DOI |
| Hepatotoxicity | — | Aerial part of plants | — | Human (as organism) | Case report | Resolve DOI |
| Hepatotoxicity | Liver | Aerial part of plants | Solvent extraction | House mouse (as animal) | Acute toxicity | Resolve DOI |
| Hepatotoxicity | Liver | Aerial part of plants | — | Human (as organism) | Case report | No resolvable identifier |
| Hepatotoxicity | Liver | Unspecified | — | Human (as organism) | Other | No resolvable identifier |
Cited sources
The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.
- Bosisio, E., Giavarini, F., Dell'Agli, M., Galli, G., Galli, CL. Analysis by high-performance liquid chromatography of teucrin A in beverages flavoured with an extract of Teucrium chamaedrys L. . Food additives and contaminants, 2004, vol. 21, no. 5, p. 407-414. DOI
- Ravichandiran, V., Satish, P.V. A review on hepatotoxicity of phytomedicines. International journal of pharmacognosy and phytochemical research, 2013, vol. 5, no. 3, p. 186-191.
- De Vincenzi, M., Maialetti, F., Silano, M. Constituents of aromatic plants: teucrin A. Fitoterapia, 2003, vol. 74, no. 7-8, p. 746-749. DOI
- Furbee, RB., Barlotta, KS., Allen, MK., Holstege, CP. Hepatotoxicity associated with herbal products. Clinics in laboratory medicine, 2006, vol. 26, no. 1, p. 227-+. DOI
- Stedman, C. Herbal hepatotoxicity. Seminars in liver disease, 2002, vol. 22, no. 2, p. 195-206. DOI
- Haslan, Haszianaliza., Suhaimi, Farihah Haji., Das, Srijit. Herbal Supplements and Hepatotoxicity: A Short Review. Natural product communications, 2015, vol. 10, no. 10, p. 1779-1784.
- Ricci, Andreina., Piccolella, Simona., Fiorentino, Antonio., Pepi, Federico., D'Abrosca, Brigida., Monaco, Pietro. A tandem mass spectrometric investigation of the low-energy collision-activated fragmentation of neo-clerodane diterpenes . Rapid communications in mass spectrometry, 2010, vol. 24, no. 11, p. 1543-1556. DOI
- Rader, Jeanne I., Delmonte, Pierluigi., Trucksess, Mary W. Recent studies on selected botanical dietary supplement ingredients. Analytical and bioanalytical chemistry, 2007, vol. 389, no. 1, p. 27-35. DOI
- Lekehal, M., Pessayre, D., Lereau, JM., Moulis, C., Fouraste, I., Fau, D. Hepatotoxicity of the herbal medicine germander: Metabolic activation of its furano diterpenoids by cytochrome P450 3A depletes cytoskeleton-associated protein thiols and forms plasma membrane blebs in rat hepatocytes . Hepatology, 1996, vol. 24, no. 1, p. 212-218. DOI
- Lin, Long-Ze., Harnly, James M., Upton, Roy. Comparison of the Phenolic Component Profiles of Skullcap (Scutellaria lateriflora) and Germander (Teucrium canadense and T. chamaedrys), a Potentially Hepatotoxic Adulterant . Phytochemical analysis, 2009, vol. 20, no. 4, p. 298-306. DOI
- KOUZI, SA., MCMURTRY, RJ., NELSON, SD. HEPATOTOXICITY OF GERMANDER (TEUCRIUM-CHAMAEDRYS L) AND ONE OF ITS CONSTITUENT NEOCLERODANE DITERPENES TEUCRIN-A IN THE MOUSE . Chemical research in toxicology, 1994, vol. 7, no. 6, p. 850-856. DOI
- Konuklugil, Belma. Investigation of podophyllotoxin in some plants in Lamiaceae using HPLC. Ankara universitesi eczacilik fakultesi dergisi, 1996, vol. 25, no. 1, p. 23-27.
Boundary
A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.
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