Botanical species · safety record

Theobroma cacao

The EFSA Compendium of Botanicals holds 1 constituent measurement and 1 adverse-effect record for Theobroma cacao. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Theobroma cacao L.

1Constituent measurements

1Safety records

2Cited sources

209Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 209 licensed products naming Theobroma cacao as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Dry
Extract Type TBA
Fresh

Source material stated

Bean
Bean Extract
Crude, dried, unroasted seeds
Dried raw unroasted beans
Fruit
Fruit Shell
Fruit extract
Fruit(s)

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Theobromine	Seed	Powder	40 Milligram/gram	HPLC-DAD	Resolve DOI

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Neurotoxicity	Neurologic: central nervous system	Seed	—	Dog (as animal)	Case report	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Johnston, J.J. Evaluation of cocoa- and coffee-derived methylxanthines as toxicants for the control of pest coyotes. Journal of agricultural and food chemistry, 2005, vol. 53, no. 10, p. 4069-4075. DOI
Wishart, DS., Jewison, T., Guo, AC., Wilson, M., Knox, C., Liu, Y., Djoumbou, Y., Mandal, R., Aziat, F., Dong, E., Bouatra, S., Sinelnikov, I., Arndt, D., Xia, J., Liu, P., Yallou, F., Bjorndahl, T., Perez-Pineiro, R., Eisner, R., Allen, F., Neveu, V., Greiner, R., Scalbert, A. Theobromine (HMDB02825).. Human metabolome database, 2006, vol. 3.0.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature