Botanical species · safety record

Thuja occidentalis

The EFSA Compendium of Botanicals holds 28 constituent measurements and 3 adverse-effect records for Thuja occidentalis. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Thuja occidentalis L.

28Constituent measurements

3Safety records

12Cited sources

202Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 202 licensed products naming Thuja occidentalis as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Dry
Fresh

Source material stated

Aerial parts
Aerial parts extract
Branch terminal leafy
Branch(es)
Brindille feuillue
Fresh leaf
Fresh leafy one year old twigs
Fresh leafy, one-year-old twigs

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Alkaloids	Bark	Solvent extraction	—	Phytochemical screening	Resolve DOI
Alpha-cedrol	Leaves	Essential oil	10.3 Percent	GC-MS	Resolve DOI
Alpha-thujone	Leaves	Essential oil	≤ 56 Percent	GC-MS	Resolve DOI
Alpha-thujone	Leaves	Essential oil	≥ 39 Percent	GC-MS	Resolve DOI
Alpha-thujone	Leaves	Essential oil	49.75 Percent	GC-MS	Resolve DOI
Beta-thujone	Leaves	Essential oil	3.14 Percent	GC-MS	Resolve DOI
Beta-thujone	Leaves	Essential oil	≤ 11 Percent	GC-MS	Resolve DOI
Beta-thujone	Leaves	Essential oil	≥ 7.2 Percent	GC-MS	Resolve DOI
Camphor	Leaves	Essential oil	≥ 1.5 Percent	GC-MS	Resolve DOI
Camphor	Leaves	Essential oil	≤ 3.3 Percent	GC-MS	Resolve DOI
Deoxypodophyllotoxin	Bark	Solvent extraction	—	HPLC-ELSD	Resolve DOI
Deoxypodophyllotoxin	Leaves	Solvent extraction	—	HPLC-ELSD	Resolve DOI
Deoxypodophyllotoxin	Aerial part of plants	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Fenchone	Leaves	Essential oil	≤ 15 Percent	GC-MS	Resolve DOI
Fenchone	Leaves	Essential oil	≥ 6 Percent	GC-MS	Resolve DOI
Lignans	Leaves	Solvent extraction	—	GC-MS	Resolve DOI
Lignans	Aerial part of plants	Solvent extraction	—	GC-MS	Resolve DOI
Myrcene	Leaves	Essential oil	1.27 Percent	GC-MS	Resolve DOI
Myrcene	Leaves	Essential oil	2.1 Percent	GC-MS	Resolve DOI
Saponins	Bark	Solvent extraction	—	Phytochemical screening	Resolve DOI
Tannins	Leaves	Solvent extraction	—	Phytochemical screening	Resolve DOI
Tannins	Bark	Solvent extraction	—	Phytochemical screening	Resolve DOI
Yatein	Aerial part of plants	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Alpha-thujone	Unspecified	Essential oil	10.4 Percent	GC-MS	No resolvable identifier
Beta-thujone	Unspecified	Essential oil	52.1 Percent	GC-MS	No resolvable identifier
Camphor	Unspecified	Essential oil	2.6 Percent	GC-MS	No resolvable identifier
Fenchone	Unspecified	Essential oil	14.1 Percent	GC-MS	No resolvable identifier
Myrcene	Leaves	Essential oil	1.69 Percent	GC-MS	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Digestive	Digestive	Aerial part of plants	—	Horse (as animal)	Other	Resolve DOI
Neurotoxicity	Neurologic	Unspecified	—	Human (as organism)	Other	Resolve DOI
Other toxicities	—	Aerial part of plants	Solvent extraction	House mouse (as animal)	Acute toxicity	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Kupeli Akkol, Esra., Ilhan, Mert., Ayse Demirel, Murside., Keles, Hikmet., Tumen, Ibrahim., Suntar, Ipek. Thuja occidentalis L. and its active compound, alpha-thujone: Promising effects in the treatment of polycystic ovary syndrome without inducing osteoporosis. . Journal of ethnopharmacology, 2015, vol. 168, p. 25-30. DOI
Logarto Parra, A., Silva Yhebra, R., Guerra Sardinas, I., Iglesias Buela, L. Comparative study of the assay of Artemia salina L. and the estimate of the medium lethal dose (LD50 value) in mice, to determine oral acute toxicity of plant extracts. . Phytomedicine : international journal of phytotherapy and phytopharmacology, 2001, vol. 8, no. 5, p. 395-400.
Pavela, Roman., Stepanycheva, Elena., Shchenikova, Anna., Chermenskaya, Taisiya., Petrova, Mariya. Essential oils as prospective fumigants against Tetranychus urticae Koch. Industrial crops and products, 2016, vol. 94, p. 755-761.
Kamdem, P.D., Hanover, J.W., Gage, D.A. Contribution to the study of the essential oil of Thuja occidentalis L.. Journal of essential oil research, 1993, vol. 5, no. 2, p. 117-122. DOI
Yang, Jin., Liang, Qian., Wang, Mei., Jeffries, Cynthia., Smithson, David., Tu, Ying., Boulos, Nidal., Jacob, Melissa R., Shelat, Anang A., Wu, Yunshan., Ravu, Ranga Rao., Gilbertson, Richard., Avery, Mitchell A., Khan, Ikhlas A., Walker, Larry A., Guy, R. Kiplin., Li, Xing-Cong. UPLC-MS-ELSD-PDA as a Powerful Dereplication Tool to Facilitate Compound Identification from Small-Molecule Natural Product Libraries . Journal of natural products, 2014, vol. 77, no. 4, p. 902-909. DOI
Caloni, F., Cortinovis, C. Plants poisonous to horses in Europe. Equine veterinary education, 2015, vol. 27, no. 5, p. 269-274. DOI
Burkhard, PR., Burkhardt, K., Haenggeli, CA., Landis, T. Plant-induced seizures: reappearance of an old problem. Journal of neurology, 1999, vol. 246, no. 8, p. 667-670. DOI
Chang, LC., Song, LL., Park, EJ., Luyengi, L., Lee, KJ., Farnsworth, NR., Pezzuto, JM., Kinghorn, AD. Bioactive constituents of Thuja occidentalis. Journal of natural products, 2000, vol. 63, no. 9, p. 1235-1238. DOI
Benelli, Giovanni., Flamini, Guido., Canale, Angelo., Cioni, Pier Luigi., Conti, Barbara. Toxicity of some essential oil formulations against the Mediterranean fruit fly Ceratitis capitata (Wiedemann) (Diptera Tephritidae) . Crop protection, 2012, vol. 42, p. 223-229. DOI
Khatun, A., Rahman, M., Haque, T., Rahman, M.M., Akter, M., Akter, S., Jhumur, A. Cytotoxicity potentials of eleven Bangladeshi medicinal plants. Scientific World Journal, 2014, vol. 2014. DOI
Cantrell, Charles L., Zheljazkov, Valcho D., Osbrink, Weste L. A., Castro, Amaya., Maddox, Victor., Craker, Lyle E., Astatkie, Tess. Podophyllotoxin and essential oil profile of Juniperus and related species. Industrial crops and products, 2013, vol. 43, p. 668-676.
Kawai, S., Sugishita, K., Ohashi, H. Identification of Thuja occidentalis lignans and its biosynthetic relationship . Phytochemistry, 1999, vol. 51, no. 2, p. 243-247. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

Continue

Independent literature