Botanical species · safety record

Tinospora cordifolia

The EFSA Compendium of Botanicals holds 20 constituent measurements and 1 adverse-effect record for Tinospora cordifolia. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Tinospora cordifolia (Willd.) Miers

20Constituent measurements

1Safety records

8Cited sources

167Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 167 licensed products naming Tinospora cordifolia as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Dry
Extract Type TBA

Source material stated

Flowers
Leaf
Leaf and stem
Leaves
Racine
Root
Root extract
Stem

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Alkaloids	Stem / stalk	Solvent extraction	—	GC-MS	Resolve DOI
Alkaloids	Stem / stalk	Solvent extraction	—	Phytochemical screening	Resolve DOI
Furan derivatives	Stem / stalk	Solvent extraction	—	HPLC-DAD	Resolve DOI
Isoquinoline alkaloids	Stem / stalk	Solvent extraction	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Saponins	Stem / stalk	Solvent extraction	—	Phytochemical screening	Resolve DOI
Tannins	Stem / stalk	Solvent extraction	—	Phytochemical screening	Resolve DOI
Alkaloids	Stem / stalk	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Aporphine alkaloids	Stem / stalk	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Corydine	Stem / stalk	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Isocorydine	Stem / stalk	Solvent extraction	≤ 1.04 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Isocorydine	Stem / stalk	Solvent extraction	≥ 0.28 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Jatrorrhizine	Stem / stalk	Solvent extraction	≥ 1.28 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Jatrorrhizine	Stem / stalk	Solvent extraction	≤ 1.7 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Magnoflorine	Stem / stalk	Solvent extraction	≥ 3.03 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Magnoflorine	Stem / stalk	Solvent extraction	≤ 7.28 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Palmatine	Stem / stalk	Solvent extraction	≥ 1.09 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Palmatine	Stem / stalk	Solvent extraction	≤ 2.31 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Pregnane derivatives	Stem / stalk	Solvent extraction	0.75 Percent	GC-MS	No resolvable identifier
Tetrahydropalmatin	Stem / stalk	Solvent extraction	≥ 0.29 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Tetrahydropalmatin	Stem / stalk	Solvent extraction	≤ 0.77 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Other toxicities	—	Aerial part of plants	Solvent extraction	Brine shrimp (as animal)	Acute toxicity	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Bajpai, Vikas., Singh, Awantika., Chandra, Preeti., Negi, M. P. S., Kumar, Nikhil., Kumar, Brijesh. Analysis of phytochemical variations in dioecious Tinospora cordifolia stems using HPLC/QTOF MS/MS and UPLC/QqQLIT-MS/MS. Phytochemical Analysis, 2016, p. 92-99.
Patel, Mayurkumar B., Mishra, Shrihari. Isoquinoline Alkaloids from Tinospora cordifolia Inhibit Rat Lens Aldose Reductase . Phytotherapy research, 2012, vol. 26, no. 9, p. 1342-1347. DOI
Ahmed, F., Islam, F., Nahar, N., Ahmed, M., Rana, A.H., Hasanur Rahman, K.M., Hossain, M.M., Rahmatullah, M. Assessment of bioactivity of Bangladeshi medicinal plants using brine shrimp lethality assay. Advances in natural and applied sciences, 2012, vol. 6, no. 8, p. 1325-1329.
Sengupta, M., Sharma, GD., Chakraborty, B. Effect of aqueous extract of Tinospora cordifolia on functions of peritoneal macrophages isolated from CCl4 intoxicated male albino mice. BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2011, vol. 11. DOI
Singh, Deepika., Chaudhuri, Prabir K. (+) Corydine from the Stems of Tinospora cordifolia. Asian journal of chemistry, 2015, p. 1567-1568.
Patel, Arti., Bigoniya, Papiya., Singh, Chandra Shekhar., Patel, Narayan Singh. Radioprotective and cytoprotective activity of Tinospora cordifolia stem enriched extract containing cordifolioside-A . Indian journal of pharmacology, 2013, vol. 45, no. 3, p. 237-243. DOI
Patel, MB., Mishra, SM. Magnoflorine from Tinospora cordifolia stem inhibits alpha-glucosidase and is antiglycemic in rats. JOURNAL OF FUNCTIONAL FOODS, 2012, vol. 4, no. 1, p. 79-86. DOI
Sharma, Upendra., Bala, Manju., Kumar, Praveen., Rampal, Geetanjali., Kumar, Neeraj., Singh, Bikram., Arora, Saroj. Antimutagenic extract from Tinospora cordifolia and its chemical composition . Journal of medicinal plants research, 2010, vol. 4, no. 23, p. 2488-2494.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature