Botanical species · safety record
Tinospora crispa
The EFSA Compendium of Botanicals holds 12 constituent measurements and 2 adverse-effect records for Tinospora crispa. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.
Accepted name in source: Tinospora crispa (L.) Hook. f. & Thomson
Regulatory presence
No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.
What the records describe
Constituents measured
- Alkaloids4
- Clerodane-type diterpenes2
- Diterpene lactones2
- Aporphine alkaloids1
- Eleutheroside b1
- Furan derivatives1
- Magnoflorine1
Plant parts
- Stem9
- stalk9
- Live plants2
- Unspecified1
Preparations
- Solvent extraction7
- Drying (dehydration)2
Effect types
- Hepatotoxicity2
Target tissues
- Liver2
Recorded constituents
What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.
| Substance | Plant part | Preparation | Concentration | Analytical method | Source |
|---|---|---|---|---|---|
| Alkaloids | Stem / stalk | Solvent extraction | — | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | Resolve DOI |
| Alkaloids | Stem / stalk | Solvent extraction | — | Nuclear Magnetic Resonance (NMR) | Resolve DOI |
| Alkaloids | Stem / stalk | Solvent extraction | — | Standard Chromatographic tests (paper- thin layer- and column chromatography) | Resolve DOI |
| Aporphine alkaloids | Stem / stalk | — | — | Unspecified | Resolve DOI |
| Clerodane-type diterpenes | Unspecified | Solvent extraction | — | Nuclear Magnetic Resonance (NMR) | Resolve DOI |
| Clerodane-type diterpenes | Stem / stalk | — | — | Unspecified | Resolve DOI |
| Diterpene lactones | Stem / stalk | Solvent extraction | — | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | Resolve DOI |
| Diterpene lactones | Stem / stalk | — | — | Unspecified | Resolve DOI |
| Eleutheroside b | Live plants | Solvent extraction | 467 Microgram/millilitre | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | Resolve DOI |
| Magnoflorine | Live plants | Solvent extraction | 281 Microgram/millilitre | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | Resolve DOI |
| Alkaloids | — | — | — | — | No resolvable identifier |
| Furan derivatives | — | — | — | — | No resolvable identifier |
Recorded adverse effects
Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.
| Effect | Target tissue | Plant part | Preparation | Test organism | Test type | Source |
|---|---|---|---|---|---|---|
| Hepatotoxicity | Liver | Stem / stalk | Drying (dehydration) | Human (as organism) | Case report | Resolve DOI |
| Hepatotoxicity | Liver | Stem / stalk | Drying (dehydration) | Human (as organism) | Study with volunteers | No resolvable identifier |
Cited sources
The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.
- Langrand, J., Regnault, H., Cachet, X., Bouzidi, C., Villa, AF., Serfaty, L., Garnier, R., Michel, S. Toxic hepatitis induced by a herbal medicine: Tinospora crispa. PHYTOMEDICINE, 2014, vol. 21, no. 8-9, p. 1120-1123. DOI
- Thomas Alex., Kumar D Suresh., Rajesh E K. The Significance of Tinospora crispa in Treatment of Diabetes Mellitus. Phytotherapy research : PTR, None.
- Hamid, HA., Yusoff, MM., Liu, M., Karim, MR. alpha-Glucosidase and alpha-amylase inhibitory constituents of Tinospora crispa: Isolation and chemical profile confirmation by ultra-high performance liquid chromatography-quadrupole time-of-flight/mass spectrometry. JOURNAL OF FUNCTIONAL FOODS, 2015, vol. 16, p. 74-80. DOI
- Ahmad, Waqas., Jantan, Ibrahim., Kumolosasi, Endang., Bukhari, Syed Nasir Abbas. Standardized extract of Tinospora crispa stimulates innate and adaptive immune responses in Balb/c mice. . Food & function, 2016, vol. 7, no. 3, p. 1380-9. DOI
- PACHALY, P., ADNAN, AZ., WILL, G. NMR-ASSIGNMENTS OF N-ACYLAPORPHINE ALKALOIDS FROM TINOSPORA-CRISPA. Planta medica, 1992, vol. 58, no. 2, p. 184-187. DOI
- Mantaj, J., Rahman, SMA., Bokshi, B., Hasan, CM., Jackson, PJM., Parsons, RB., Rahman, KM. Crispene E, a cis-clerodane diterpene inhibits STAT3 dimerization in breast cancer cells. ORGANIC & BIOMOLECULAR CHEMISTRY, 2015, vol. 13, no. 13, p. 3882-3886. DOI
- Yusoff, M., Hamid, H., Houghton, P. Anticholinesterase Inhibitory Activity of Quaternary Alkaloids from Tinospora crispa. MOLECULES, 2014, vol. 19, no. 1, p. 1201-1211. DOI
- Koay, Yen Chin., Amir, Faheem. A Review of the Secondary Metabolites and Biological Activities of Tinospora crispa (Menispermaceae) . Tropical journal of pharmaceutical research, 2013, vol. 12, no. 4, p. 641-649. DOI
Boundary
A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.
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