Botanical species · safety record
Trifolium arvense
The EFSA Compendium of Botanicals holds 14 constituent measurements and 1 adverse-effect record for Trifolium arvense. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.
Accepted name in source: Trifolium arvense L.
Regulatory presence
No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.
What the records describe
Constituents measured
- Biochanin-a1
- Daidzein1
- Daidzin1
- Formononetin1
- Genistein1
- Genistin1
- Glycitein1
- Irilone1
- Isoflavones1
- Pratensein1
Plant parts
- Leaves14
- Seed1
Preparations
- Solvent extraction14
- Raw, no heat treatment1
Effect types
- Reproductive1
Target tissues
- Uterus1
Recorded constituents
What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.
| Substance | Plant part | Preparation | Concentration | Analytical method | Source |
|---|---|---|---|---|---|
| Biochanin-a | Leaves | Solvent extraction | 49.4 Milligram/kilogram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | Resolve DOI |
| Daidzein | Leaves | Solvent extraction | 8.1 Milligram/kilogram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | Resolve DOI |
| Daidzin | Leaves | Solvent extraction | 6.3 Milligram/kilogram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | Resolve DOI |
| Formononetin | Leaves | Solvent extraction | 10.5 Milligram/kilogram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | Resolve DOI |
| Genistein | Leaves | Solvent extraction | 61.5 Milligram/kilogram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | Resolve DOI |
| Genistin | Leaves | Solvent extraction | 21.3 Milligram/kilogram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | Resolve DOI |
| Glycitein | Leaves | Solvent extraction | 16.9 Milligram/kilogram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | Resolve DOI |
| Irilone | Leaves | Solvent extraction | 1.7 Milligram/kilogram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | Resolve DOI |
| Isoflavones | Leaves | Solvent extraction | 204.5 Milligram/kilogram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | Resolve DOI |
| Pratensein | Leaves | Solvent extraction | 17.4 Milligram/kilogram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | Resolve DOI |
| Proanthocyanidins (condensed tannins) | Leaves | Solvent extraction | — | Standard Chromatographic tests (paper- thin layer- and column chromatography) | Resolve DOI |
| Prunetin | Leaves | Solvent extraction | 8.3 Milligram/kilogram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | Resolve DOI |
| Puerarin | Leaves | Solvent extraction | 2.9 Milligram/kilogram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | Resolve DOI |
| Saponins | Seed | Solvent extraction | 7.6 Milligram/gram | Standard Chromatographic tests (paper- thin layer- and column chromatography) | No resolvable identifier |
Recorded adverse effects
Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.
| Effect | Target tissue | Plant part | Preparation | Test organism | Test type | Source |
|---|---|---|---|---|---|---|
| Reproductive | Uterus | Leaves | Raw, no heat treatment | Cattle (as animal) | Case report | Resolve DOI |
Cited sources
The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.
- Visnevschi-Necrasov, T., Faria, M.A., Cunha, S.C., Harris, J., Meimberg, H.W.E., Curto, M.A.C., Gra�a Pereira, M., Oliveira, M.B.P.P., Nunes, E. Isoflavone synthase (IFS) gene phylogeny in Trifolium species associated with plant isoflavone contents. Plant systematics and evolution, 2013, vol. 299, no. 2, p. 357-367. DOI
- Oleszek, Wieslaw., Stochmal, Anna. Triterpene saponins and flavonoids in the seeds of Trifolium species. Phytochemistry, 2002, p. 165-170.
- Al-Qura'n, S. Ethnobotanical survey of folk toxic plants in southern part of Jordan. Toxicon, 2005, vol. 46, no. 2, p. 119-129. DOI
- TANNER, GJ., MOORE, AE., LARKIN, PJ. PROANTHOCYANIDINS INHIBIT HYDROLYSIS OF LEAF PROTEINS BY RUMEN MICROFLORA IN-VITRO . British journal of nutrition, 1994, vol. 71, no. 6, p. 947-958. DOI
Boundary
A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.
Continue
Europe PMC
Every record indexed for this species, resolvable and re-runnable.
All speciesSubstance index
Search and browse every species this world holds under source and hash.
Before anything elseSafety Centre
Interactions, contraindications and the escalation boundary this world does not cross.
In its own termsTraditions
How the living traditions approach preparation, use and context.