Botanical species · safety record
Trifolium pratense
The EFSA Compendium of Botanicals holds 12 constituent measurements and 1 genotoxicity assay for Trifolium pratense. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.
Accepted name in source: Trifolium pratense L.
Regulatory presence
Health Canada's Licensed Natural Health Products Database holds 414 licensed products naming Trifolium pratense as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.
Extract types on licence
Source material stated
What the records describe
Constituents measured
- Isoflavones6
- Daidzein1
- Daidzin1
- Formononetin1
- Genistein1
- Genistin1
- Ononin1
Plant parts
- Aerial part of plants6
- Live plants2
- Flower1
- Leaves1
- Stem1
- Unspecified1
- stalk1
Preparations
- Solvent extraction12
Recorded constituents
What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.
| Substance | Plant part | Preparation | Concentration | Analytical method | Source |
|---|---|---|---|---|---|
| Isoflavones | Unspecified | Solvent extraction | — | Unspecified | Resolve DOI |
| Isoflavones | Live plants | Solvent extraction | ≤ 12753 Microgram/gram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | Resolve DOI |
| Isoflavones | Live plants | Solvent extraction | ≥ 8923 Microgram/gram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | Resolve DOI |
| Isoflavones | Leaves | Solvent extraction | 11970 Microgram/gram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | Resolve DOI |
| Isoflavones | Flower | Solvent extraction | 3297 Microgram/gram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | Resolve DOI |
| Isoflavones | Stem / stalk | Solvent extraction | 4896 Microgram/gram | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | Resolve DOI |
| Daidzein | Aerial part of plants | Solvent extraction | 859.8 Nanogram/millilitre | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | No resolvable identifier |
| Daidzin | Aerial part of plants | Solvent extraction | 5407.2 Nanogram/millilitre | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | No resolvable identifier |
| Formononetin | Aerial part of plants | Solvent extraction | 9165.8 Nanogram/millilitre | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | No resolvable identifier |
| Genistein | Aerial part of plants | Solvent extraction | 1423.2 Nanogram/millilitre | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | No resolvable identifier |
| Genistin | Aerial part of plants | Solvent extraction | 18057 Nanogram/millilitre | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | No resolvable identifier |
| Ononin | Aerial part of plants | Solvent extraction | 50979.4 Nanogram/millilitre | High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) | No resolvable identifier |
Genotoxicity testing
Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.
| Outcome | Endpoint | Test | Tested organism | Metabolic activation | Source |
|---|---|---|---|---|---|
| Positive | gene mutation | in vitro mammalian cell micronucleus test | Hamster (as animal) | No data | Resolve DOI |
Cited sources
The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.
- Scheffler, A., Albrecht, A.E., Esch, H.L., Lehmann, L. Mutagenic potential of the isoflavone irilone in cultured V79 cells. Toxicology letters, 2015, vol. 234, no. 2, p. 81-91. DOI
- Hanganu, Daniela., Vlase, Laurian., Olah, Neli. LC/MS ANALYSIS OF ISOFLAVONES FROM FABACEAE SPECIES EXTRACTS. Farmacia, 2010, vol. 58, no. 2, p. 177-183.
- Andres, S., Abraham, K., Appel, K.E., Lampen, A. Risks and benefits of dietary isoflavones for cancer. Critical reviews in toxicology, 2011, vol. 41, no. 6, p. 463-506. DOI
- Sivesind, E., Seguin, P. Effects of the environment, cultivar, maturity, and preservation method on red clover isoflavone concentration . Journal of agricultural and food chemistry, 2005, vol. 53, no. 16, p. 6397-6402. DOI
Boundary
A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.
Continue
Europe PMC
Every record indexed for this species, resolvable and re-runnable.
All speciesSubstance index
Search and browse every species this world holds under source and hash.
Before anything elseSafety Centre
Interactions, contraindications and the escalation boundary this world does not cross.
In its own termsTraditions
How the living traditions approach preparation, use and context.