Botanical species · safety record

Trigonella foenum-graecum

The EFSA Compendium of Botanicals holds 3 constituent measurements and 11 adverse-effect records for Trigonella foenum-graecum. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Trigonella foenum-graecum L.

3Constituent measurements

11Safety records

7Cited sources

1,168Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 1,168 licensed products naming Trigonella foenum-graecum as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Dry
Extract Type TBA
solid

Source material stated

Aged bark
Dried ripe seeds
Dried seed
Fenugreek Seed
Grain
Grain(s)
Graine
Leaf

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Steroidal saponins	Seed	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Alkaloids	Seed	Solvent extraction	—	Phytochemical screening	No resolvable identifier
Saponins	Seed	Solvent extraction	—	Phytochemical screening	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Hemopoietic	Cardiovascular / haematological	Seed	Solvent extraction	House mouse (as animal)	Short-term toxicity	Resolve DOI
Systemic	—	Seed	Solvent extraction	House mouse (as animal)	Short-term toxicity	Resolve DOI
Teratogenic	—	Seed	Solvent extraction	House mouse (as animal)	Reproduction toxicity	Resolve DOI
Teratogenic	—	Seed	Solvent extraction	House mouse (as animal)	Reproduction toxicity	Resolve DOI
Teratogenic	—	Seed	Solvent extraction	House mouse (as animal)	Reproduction toxicity	Resolve DOI
Teratogenic	—	Seed	Solvent extraction	House mouse (as animal)	Reproduction toxicity	Resolve DOI
Musclo-skeletal	Muscle, skeletal	Unspecified	Raw, no heat treatment	Ruminants (generic) (as animal)	Case report	No resolvable identifier
Other toxicities	Neurologic	Seed	Solvent extraction	Rat (as animal)	Acute toxicity	No resolvable identifier
Reproductive	Testes	Seed	—	House mouse (as animal)	Subchronic	No resolvable identifier
Reproductive	Uterus	Seed	—	House mouse (as animal)	Subchronic	No resolvable identifier
Reproductive	Uterus	Seed	Solvent extraction	Rat (as animal)	Reproduction toxicity	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Shlosberg, A., Egyed, M N. Examples of poisonous plants in Israel of importance to animals and man.. Archives of toxicology. supplement. = archiv fur toxikologie. supplement, 1983, vol. 6, p. 194-6.
Kandhare, Amit D., Bodhankar, Subhash L., Mohan, V., Thakurdesai, Prasad A. Acute and repeated doses (28 days) oral toxicity study of glycosides based standardized fenugreek seed extract in laboratory mice . Regulatory toxicology and pharmacology, 2015, vol. 72, no. 2, p. 323-334. DOI
Al-Yahya, Abdulaziz A. Reproductive, cytological and biochemical toxicity of fenugreek in male Swiss albino mice. African journal of pharmacy and pharmacology, 2013, p. 2072-2080.
Dande, P., Patil, S. Evaluation of saponins from Trigonella foenum graecum seeds for its antifertility activity. Asian journal of pharmaceutical and clinical research, 2012, vol. 5, no. SUPPL. 3, p. 154-157.
Khalki, Loubna., M'hamed, Saadia Ba., Bennis, Mohamed., Chait, Abderrahman., Sokar, Zahra. Evaluation of the developmental toxicity of the aqueous extract from Trigonella foenum-graecum (L.) in mice . Journal of ethnopharmacology, 2010, vol. 131, no. 2, p. 321-325. DOI
Kawabata, Tetsuro., Cui, Ming-Yue., Hasegawa, Tatsuya., Takano, Fumihide., Ohta, Tomihisa. Anti-Inflammatory and Anti-Melanogenic Steroidal Saponin Glycosides from Fenugreek (Trigonella foenum-graecum L.) Seeds . Planta medica, 2011, vol. 77, no. 7, p. 705-710. DOI
Mowla, Asmena., Alauddin, M., Rahman, Md. Atiar., Ahmed, Kabir. ANTIHYPERGLYCEMIC EFFECT OF TRIGONELLA FOENUM-GRAECUM (FENUGREEK) SEED EXTRACT IN ALLOXAN-INDUCED DIABETIC RATS AND ITS USE IN DIABETES MELLITUS: A BRIEF QUALITATIVE PHYTOCHEMICAL AND ACUTE TOXICITY TEST ON THE EXTRACT . African journal of traditional complementary and alternative medicines, 2009, vol. 6, no. 3, p. 255-261.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature